Fordyce granules are intraoral sebaceous glands, named after the American doctor John Addison Fordyce (1896). Since sebaceous glands are considered to be dermal adnexal structures, the intraoral localization is considered as “ectopic.” However, because of the incidence, they can also be considered as a normal anatomic variation. They can be the origin of sebaceous hyperplasia, sebaceous adenomas, or sebaceous carcinomas, although tumors are exceedingly rare. Certain of these cutaneous sebaceous conditions are part of Muir-Torre syndrome, which is considered as a phenotypical subtype of Lynch syndrome (hereditary nonpolyposis colon cancer (HNPCC)). A relationship between Fordyce granules and HNPCC has been demonstrated.
References and Further Reading
- Fordyce, J. (1896). A peculiar affection of the mucous membrane of the lip and oral cavity. Journal of Cutaneous and Genitourinary Diseases, 14, 413–419.Google Scholar