Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Fordyce Granules

Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_707-1



Fordyce granules are intraoral sebaceous glands, named after the American doctor John Addison Fordyce (1896). Since sebaceous glands are considered to be dermal adnexal structures, the intraoral localization is considered as “ectopic.” However, because of the incidence, they can also be considered as a normal anatomic variation. They can be the origin of sebaceous hyperplasia, sebaceous adenomas, or sebaceous carcinomas, although tumors are exceedingly rare. Certain of these cutaneous sebaceous conditions are part of Muir-Torre syndrome, which is considered as a phenotypical subtype of Lynch syndrome (hereditary nonpolyposis colon cancer (HNPCC)). A relationship between Fordyce granules and HNPCC has been demonstrated.

Fordyce granules clinically present as multiple small (1–3 mm), yellow, or yellow–white mucosal papules (Fig. 1).
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References and Further Reading

  1. Abuzeid, M., et al. (1996). Intraoral sebaceous carcinoma. Journal of Laryngology and Otology, 110, 500–502.PubMedGoogle Scholar
  2. Daley, T. D. (1992). Intraoral sebaceous hyperplasia. Oral Surgery, Oral Medicine, and Oral Pathology, 74, 343–347.CrossRefGoogle Scholar
  3. Fernandez-Flores, A., & Rodriguez Peralto, J. L. (2017). Mismatch repair protein expression in Fordyce granules. Applied Immunohistochemistry & Molecular Morphology, 75, 209–212.CrossRefGoogle Scholar
  4. Fordyce, J. (1896). A peculiar affection of the mucous membrane of the lip and oral cavity. Journal of Cutaneous and Genitourinary Diseases, 14, 413–419.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyThe Netherlands Cancer Institute, Antoni van Leeuwenhoek HospitalAmsterdamThe Netherlands