Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken


Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_703-1



A fibroma is the most common soft tissue exophytic lesion of the oral mucosa. It is a reactive lesion, caused by chronic trauma to the oral mucous membranes. The submucosal mass is a result of exuberant fibrous connective tissue repair.

Clinical Features


According to a study by Bouquot et al., (irritation) fibromas are found in 12.0/1,000 population.


No age predilection.


No gender predilection.


The lesion is typically found in easily traumatized areas, most prevalent on the buccal mucosa, lateral borders of the tongue, and lower lip. Larger fibromas may occur along the borders of (ill-fitting) dentures, on the palate, or gingival.


Local surgical excision.


Excellent, recurrences are extremely rare.


A fibroma appears as a localized, exophytic, and submucosal swelling, similar in color to the surrounding mucosa. The surface may appear...

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References and Further Reading

  1. Bouquot, J. E., & Gundlach, K. K. H. (1986). Oral exophytic lesions in 23,616 white Americans over 35 years of age. Oral Surgery, Oral Medicine, and Oral Pathology, 62, 284–291.CrossRefPubMedGoogle Scholar
  2. Dayan, D., Bodner, L., Hammel, I., & Wolman, M. (1994). Histochemical characterization of collagen fibers in fibrous overgrowth (irritation fibroma) of the oral mucosa: Effect of age and duration of lesion. Archives of Gerontology and Geriatrics, 18, 53–57.CrossRefPubMedGoogle Scholar
  3. Kinoshita, H., Ogasawara, T., Toya, T., et al. (2016). Slow-growing large irritation fibroma of the anterior hard palate: A case report using immunohistochemical analysis. Journal of Maxillofacial Surgery, 15(Suppl 2), 253–257.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyThe Netherlands Cancer Institute, Antoni van Leeuwenhoek HospitalAmsterdamThe Netherlands