Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Eosinophilic Ulcer

Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_696-1



A chronic, benign, self-limiting lesion, commonly presenting as an ulceration with elevated margins on the lateral or ventral surface of the tongue of unknown etiology. It develops rapidly and usually persists for several weeks or months. It may mimic oral cancer. Due to a history of traumatic injury in about one third of the cases, a traumatic cause has been suggested. However, metachronous and multiple synchronous lesions at different sites argue for the fact that other factors than trauma must be involved.

Clinical Features


Unknown, probably relatively common.


All ages, most commonly in children and young adults. In children, the lesion has been called Riga-Fede’s disease.


Equal sex distribution. In some series, a male, in others, a female...

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References and Further Reading

  1. El-Mofty, S. K., Swanson, P. E., Wick, M. R., & Miller, A. S. (1993). Eosinophilic ulcer of the oral mucosa. Report of 38 new cases with immunohistochemical observations. Oral Surgery, Oral Medicine, and Oral Pathology, 75, 716–722.CrossRefPubMedGoogle Scholar
  2. Elzay, R. P. (1983). Traumatic ulcerative granuloma with stromal eosinophilia (Riga-Fede’s disease and traumatic eosinophilic granuloma). Oral Surgery, Oral Medicine, and Oral Pathology, 55, 497–506.CrossRefPubMedGoogle Scholar
  3. Hirshberg, A., Amariglio, N., Akrish, S., Yahalom, R., Rosenbaum, H., Okon, E., & Kaplan, I. (2006). Traumatic ulcerative granuloma with stromal eosinophilia. A reactive lesion of the oral mucosa. American Journal of Clinical Pathology, 126, 522–529.CrossRefPubMedGoogle Scholar
  4. Sarangarajan, R., Vaishanavi Vedam, V. K., Sivadas, G., Sarangarajan, A., & Meera, S. (2015). Traumatic ulcerative granuloma with stromal eosinophilia – Mystery of pathogenesis revisited. Journal of Pharmacy & Bioallied Sciences, 7(Suppl 2), S420–S423.CrossRefGoogle Scholar
  5. Segura, S., & Pujol, R. M. (2008). Eosinophilic ulcer of the oral mucosa: A distinct entity or a non-specific reactive pattern. Oral Diseases, 14, 287–295.CrossRefPubMedGoogle Scholar
  6. Segura, S., Romero, D., Mascaro, J. M., Colomo, L., Ferrando, J., & Estrach, T. (2006). Eosinophilic ulcer of the oral mucosa: Another histological simulator of CD30+ lymphoproliferative disorders. British Journal of Dermatology, 155, 460–463.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyThe Netherlands Cancer Institute, Antoni van Leeuwenhoek HospitalAmsterdamThe Netherlands