Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Bohn’s Nodules

  • Jacqueline E. van der WalEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_658-1



Small, developmental inclusion cysts in the newborn infants located on the buccal or lingual aspect of the alveolar ridge (according to the classification by Fromm (1967)) or scattered over the hard palate, near the soft palate junction (according to Bohn, around 1800), believed to be derived from the minor salivary glands. Identical cysts along the median raphe are called Epstein’s pearls, and on the crest of the alveolar ridge, gingival or alveolar cysts of the newborn, originating from the dental lamina (dental lamina cysts).

Clinical Features


Bohn’s nodules are present in 65–85% of neonates.


Bohn’s nodules are present in neonates, rarely after 3 months.


No gender predilection.


Small, 1–3 mm, white or yellow–white papules on the hard palate, along the midline, near the soft palate junction or on the buccal or lingual aspect of the alveolar ridge.


Bohn’s nodules are self-healing within a few weeks/months. The small cysts rupture spontaneously and/or fuse with the oral epithelium.


Microscopically, Bohn’s nodules are keratin-filled cysts, lined by stratified squamous epithelium, sometimes communicating with the surface (Fig. 1).
Fig. 1

A gingival cyst, having the same microscopical morphology as a Bohn’s nodule (hematoxylin and eosin)

Differential Diagnosis

References and Further Reading

  1. Alves, K. M., et al. (2004). Prevalence of palatal and alveolar cysts in babies with cleft lip and palate. Cleft Palate-Craniofacial Journal, 41, 490–493.CrossRefPubMedGoogle Scholar
  2. Cambiaghi, S., & Gelmetti, C. (2005). Bohn’s nodules. International Journal of Dermatology, 44, 753–754.CrossRefPubMedGoogle Scholar
  3. Fromm, A. (1967). Epstein’s pearls, Bohn’s nodules and inclusion-cysts of the oral cavity. Journal of Dentistry for Children, 34, 275–287.Google Scholar
  4. Neville, B. W., et al. (2009). Oral and maxillofacial pathology (3rd ed.pp. 26–27). St. Louis: Saunders/Elsevier.Google Scholar
  5. Singh, R. K., et al. (2012). Dental lamina cysts in a newborn infant. BMJ Case Reports (online publication, Oct 9). Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyThe Netherlands Cancer Institute, Antoni van Leeuwenhoek HospitalAmsterdamThe Netherlands