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Spindle Cell Hemangioma

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Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

The tumors were initially reported as “spindle cell hemangioendothelioma.”

Definition

Benign vascular proliferation composed of ectatic vascular channels, vacuolated endothelial cells, and spindled pericytes. The tumors may represent a vascular malformation.

Clinical Features

  • Incidence

    The tumors are rare, but no data on incidence exist. A subset of tumors is seen in patients with Mafucci or Klippel-Trenaunay syndrome.

  • Age

    A wide age range is affected with a peak in young adulthood (Fletcher et al. 1991; Perkins and Weiss 1996).

  • Sex

    There is no gender predilection.

  • Site

    There is a predilection for the distal extremities (Fletcher et al. 1991; Perkins and Weiss 1996).

  • Treatment

    Simple excision is adequate

  • Outcome

    Spindle cell hemangioas are benign with rare local recurrence. Further lesions may develop at the same anatomic site.

Macroscopy

Spindle cell hemangioma presents as solitary or multiple slowly enlarging, erythematous to bluish nodules measuring up to few centimeters....

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References and Further Reading

  • Fletcher, C. D., Beham, A., & Schmid, C. (1991). Spindle cell haemangioendothelioma: A clinicopathological and immunohistochemical study indicative of a non-neoplastic lesion. Histopathology, 18(4), 291–301.

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  • Kurek, K. C., Pansuriya, T. C., van Ruler, M. A., van den Akker, B., Luks, V. L., Verbeke, S. L., Kozakewich, H. P., Sciot, R., Lev, D., Lazar, A. J., Fletcher, C. D., & Bovée, J. V. (2013). R132C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. The American Journal of Pathology, 182(5), 1494–1500.

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  • Pansuriya, T. C., van Eijk, R., d’Adamo, P., van Ruler, M. A., Kuijjer, M. L., Oosting, J., Cleton-Jansen, A. M., van Oosterwijk, J. G., Verbeke, S. L., Meijer, D., van Wezel, T., Nord, K. H., Sangiorgi, L., Toker, B., Liegl-Atzwanger, B., San-Julian, M., Sciot, R., Limaye, N., Kindblom, L. G., Daugaard, S., Godfraind, C., Boon, L. M., Vikkula, M., Kurek, K. C., Szuhai, K., French, P. J., & Bovée, J. V. (2011). Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. Nature Genetics, 43(12), 1256–1261.

    Article  CAS  Google Scholar 

  • Perkins, P., & Weiss, S. W. (1996). Spindle cell hemangioendothelioma. An analysis of 78 cases with reassessment of its pathogenesis and biologic behavior. The American Journal of Surgical Pathology, 20(10), 1196–1204.

    Article  CAS  Google Scholar 

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Correspondence to Thomas Brenn .

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Brenn, T. (2020). Spindle Cell Hemangioma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5468-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5468-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

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