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Intranodal Palisaded Myofibroblastoma

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 65 Accesses

Synonyms

Intranodal hemorrhagic spindle cell tumor with amianthoid fiber

Definition

Intranodal palisaded myofibroblastoma (IPM) is a benign mesenchymal tumor arising in the lymph node.

Clinical Features

  • Incidence

    IPM is a very rare tumor of the lymph node. About 70 cases of it have been reported in the English literature since 1968.

  • Age

    IPM has been diagnosed across a wide range of ages, from 19 to 84 year old. It has a tendency to occur in the middle-aged (40–55 year old).

  • Sex

    The male-female ratio of affected patients has been reported to be 1.5–2:1. The literature review of 22 cases from 1998 to 2019 (Table 1) revealed a slight male predominance (M:F = 12:10).

  • Site

    Most cases of IPM were reported in the inguinal lymph nodes. Other reported sites include the lymph nodes of the axilla, submandible, neck, and pelvis.

  • Treatment

    Local excision is carried out in most cases.

  • Outcome

    Most reported cases have good outcomes. A local recurrence rate of 6% has been reported by Kandemir et al. (

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References and Further Reading

  • Altinbas, N. K., Oz, I., Ustuner, E., Gulpinar, B., Peker, E., Akkaya, Z., Peker, A., Ceyhan, K., & Yagci, C. (2016). Intranodal palisaded myofibroblastoma: Radiological and cytological overview. Polish Journal of Radiology, 22(81), 342–346.

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  • Bhullar, J. S., Herschman, B. R., & Dubay, L. (2013). Intranodal palisaded myofibroblastoma: A new entity of axillary tumors. The American Surgeon, 79(1), E19–E21.

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  • Black, J. O., Zhai, Q. J., Varona, O. B., Ordonez, N. G., & Luna, M. A. (2010). Primary schwannoma in a cervical lymph node. Head & Neck, 32(7), 964–969.

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  • Bouhajja, L., Jouini, R., Khayat, O., Koubâa, W., Mbarek, C., Ben Brahim, E., & Chedly-Debbiche, A. (2017). Intranodal palisaded myofibroblastoma in a submandibular lymph node. Case Reports in Otolaryngology, 2017 Oct 26. https://doi.org/10.1155/2017/7121485.

  • Cimpean, A. M., & Raica, M. (2013). Intranodal hemorrhagic spindle cell tumor with amianthoid fibers – Report of a case with emphasis to mast cell reaction and D2-40 expression. Vivo, 27(3), 395–399.

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  • Cosenza, U. M., Galati, G., Zofrea, P., Maggi, S., Marasco, A., Castelli, M., Masoni, L., & Brescia, A. (2006). Clinical and biological features of an intranodal palisaded myofibroblastoma. Anticancer Research, 26(3B), 2349–2352.

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  • Creager, A. J., & Garwacki, C. P. (1999). Recurrent intranodal palisaded myofibroblastoma with metaplastic bone formation. Archives of Pathology & Laboratory Medicine, 123(5), 433–436.

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  • D’Antonio, A., Addesso, M., Amico, P., & Fragetta, F. (2014). Axillary intranodal palisaded myofibroblastoma: Report of a case associated with chronic mastitis. BMJ Case Reports, 2014 Oct 16. https://doi.org/10.1136/bcr-2014-205877.

  • Goldblum, J. R., Folpe, A. L., & Weiss, S. W. (2013). Intranodal palisaded myofibroblastoma. In F. M. Enzinger & S. W. Weiss (Eds.), Enzinger & Weiss’s soft tissue tumors (6th ed., pp. 231–233). Philadelphia: Mosby Elsevier.

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  • Hisaoka, M., Hashiomoto, H., & Daimaru, Y. (1998). Intranodal palisaded myofibroblastoma with so-called amianthoid fibers: A report of two cases with a review of the literature. Pathology International, 48(4), 307–312.

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  • Kandemir, N. O., Barut, F., Ekinci, T., Karagülle, C., & Ozdamar, S. O. (2010). Intranodal palisaded myofibroblastoma (intranodal hemorrhagic spindle cell tumor with amianthoid fibers): A case report and literature review. Diagnostic Pathology, 5, 12.

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  • Sagar, J., Vargiamidou, A., & Manikkapurath, H. (2011). Intranodal palisaded myofibroblastoma originating from retroperitoneum: An unusual origin. BMC Clinical Pathology, 11, 7.

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  • Verset, L., Shumelinsky, F., de Wind, R., Demetter, P., & De Saint Aubain, N. (2019). Spindle cells in aspiration material from an inguinal adenopathy: Possibly a sheep in wolf’s clothing! Histopathology, 2019 Mar 12. https://doi.org/10.1111/his.13859.

  • Yim, I. H., Will, M. B., Dhaliwal, C., Salter, D. M., & Walker, W. S. (2016). Intranodal palisaded myofibroblastoma masquerading as N2 non-small cell lung carcinoma. Annals of Thoracic Surgery, 102(1), e47–e48.

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Author information

Authors and Affiliations

  1. Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Taro Mori, Yuichi Yamada & Yoshinao Oda

  2. Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan

    Masanori Hisaoka

Authors
  1. Taro Mori
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  2. Yuichi Yamada
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  3. Masanori Hisaoka
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  4. Yoshinao Oda
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Corresponding author

Correspondence to Yoshinao Oda .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Mori, T., Yamada, Y., Hisaoka, M., Oda, Y. (2020). Intranodal Palisaded Myofibroblastoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5429-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5429-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

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