Definition
Scintigraphic procedure to visualize Somatostatin Receptor (SSTR) 2 positive tumors. Usually used in the setting of well-differentiated neuroendocrine neoplasms (GEP–NET).
Principle
Indium-111 is a gamma rays emitting isotope with a relatively long half-live of 2.8 days. Pentetreotide (DTPA-Octreotide) is a somatostatin analog mainly binding to SSTR2 carrying the radioactive Indium-111. The radioactive isotope the decays by emitting gamma rays which are collimated to a specific geometry and then detected by a gamma camera. The imaging protocol usually consists of planar imaging and tomographic single photon emission tomography (SPECT) imaging.
Methodology
Scintigraphic planar and tomographic SPECT are usually acquired after 4 h, 24 h, and 48 h. Special caution has to be given to pregnancy, breast feeding, and children. In these cases, nonradiant alternatives need to...
References and Further Reading
Bombardieri, E., Ambrosini, V., Aktolun, C., Baum, R. P., Bishof-Delaloye, A., Del Vecchio, S., Maffioli, L., Mortelmans, L., Oyen, W., Pepe, G., & Chiti, A. (2010). 111In-pentetreotide scintigraphy: Procedure guidelines for tumour imaging. European Journal of Nuclear Medicine and Molecular Imaging, 37(7), 1441–1448.
Maxwell, J. E., & Howe, J. R. (2015). Imaging in neuroendocrine tumors: An update for the clinician. International Journal of Endocrine Oncology, 2(2), 159–168.
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Schaefer, N. (2021). 111In-Pentetreotide Scintigraphy. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5266-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_5266-1
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