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Urothelial Carcinoma, Giant Cell Type

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Pleomorphic giant cell carcinoma

Definition

Rare and aggressive variant of urothelial carcinoma characterized by markedly bizarre pleomorphic tumor giant cells (Moch et al. 2016).

Clinical Features

  • Incidence

    This histological variant is very uncommon with fewer than 30 cases reported in the literature (Lopez-Beltran et al. 2009; Samaratunga et al. 2016).

  • Age

    Patients age ranges from 53 to 92 years, mean 70 years.

  • Sex

    The two published case series reported a male predominance.

  • Site and presentation

    All reported cases involved the urinary bladder and presented with hematuria, dysuria, or frequency.

  • Treatment

    The patients are usually diagnosed by TURB and treated by cystoprostatectomy or cystectomy.

  • Outcome

    Giant cell urothelial carcinoma is very aggressive with most tumors presenting in clinical stage T3 or T4 with frequent lymph node metastases. The prognosis is poor, and most patients died of the disease within 2 years of diagnosis or are alive with metastasis.

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References and Further Reading

  • Lopez-Beltran, A., Blanca, A., et al. (2009). Pleomorphic giant cell carcinoma of the urinary bladder. Human Pathology, 40(10), 1461–1466.

    Article  CAS  Google Scholar 

  • Lopez-Beltran, A., Henriques, V., Montironi, R., et al. (2019). Variants and new entities of bladder cancer. Histopathology, 74, 77–96.

    Article  Google Scholar 

  • Moch, H., Humphrey, P. A., Ulbright, T. M., & Reuter, V. (2016). WHO classification of tumors of the urinary system and male genital organs. Lyon: International Agency for Research on Cancer.

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  • Samaratunga, H., Delahunt, B., et al. (2016). Pleomorphic giant cell carcinoma of the urinary bladder: An extreme form of tumour de-differentiation. Histopathology, 68(4), 533–540.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Caterina Fattorini & Maria Rosaria Raspollini

  2. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  3. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

Authors
  1. Caterina Fattorini
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  2. Antonio Lopez-Beltran
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  3. Maria Rosaria Raspollini
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Corresponding author

Correspondence to Maria Rosaria Raspollini .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Fattorini, C., Lopez-Beltran, A., Raspollini, M.R. (2019). Urothelial Carcinoma, Giant Cell Type. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4983-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4983-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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