Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Splenogonadal Fusion

  • Maurizio ColecchiaEmail author
  • Alessia Bertolotti
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4951-1



Ectopic splenic tissue connected or not to the eutopic spleen observed near the testicular parenchyma.

Clinical Features

  • Incidence

    Until now about 200 cases have been reported (Nistal et al. 2017). The majority were observed in orchiopexy or surgery for inguinal hernia repair. Only a minority of cases were suspected before surgery. Unfrequently, splenogonadal fusion is associated with germ cell tumors.

  • Age

    The age of patients ranges from new born children to 81 years old.


Generally the splenic tissue is separated from the testicular parenchyma by a thin capsule. The seminiferous epithelium only consists of dysgenetic Sertoli cells (Fig. 1). It could be joined to the testis, the epididymis, or the spermatic cord; only exceptionally, this tissue shows continuity with seminiferous tubules. It is important to recognize in frozen section examination the splenogonadal fusion to avoid unnecessary orchiectomy (Giunchi et al. 2016). Germ cell tumors associated with splenic-gonadal fusion have been linked to cryptorchidism and require treatment.
Fig. 1

Splenogonadal fusion. Splenic tissue separated from testicular parenchyma by a thin capsule

References and Further Reading

  1. Giunchi, F., Vasuri, F., Colecchia, M., Gentile, G., Garofalo, M., Schiavina, R., & Fiorentino, M. (2016). Frozen section analysis of unusual small testicular tumor masses: Report of 3 cases. Tumori, 102(Suppl 2), S106.CrossRefGoogle Scholar
  2. Nistal, M., Gonzalez-Peramato, P., & Serrano, A. (2017). Paratesticular tumor-like congenital lesion. In Clues in the diagnosis of non-tumoral testicular pathology (pp. 320–323). Cham: Springer International Publishing.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Uropathology Unit, Department of PathologyFondazione IRCCS Istituto Nazionale dei Tumori di MilanoMilanItaly
  2. 2.Department of PathologyFondazione IRCCS Istituto Nazionale dei Tumori di MilanoMilanItaly