Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Renal Mucinous Tubular and Spindle Cell Carcinoma

  • Anna Caliò
  • Diego Segala
  • Guido MartignoniEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4926-1


Renal cell tumor characterized by tubular formations merging with bland spindle cells in a myxoid stroma.

Clinical Features

  • Incidence

    This tumor accounts for less than 1% of all renal neoplasms.

  • Age

    It arises during the sixth decade of live.

  • Sex

    There is a female predilection (M:F = 1:3).

  • Site

    There is no site predilection.

  • Treatment

    Partial or radical nephrectomy is the treatment of choice.

  • Outcome

    Only rare cases have metastasized to lymph nodes and have shown sarcomatoid dedifferentiation.


The tumor is solid, pale tan to yellow that may have slight focal areas of necrosis or hemorrhage.


Mucinous tubular and spindle cell carcinoma is circumscribed and composed of branching, elongated tubules in a bubbly, basophilic, myxoid stroma (Fig. 1). Tumor cells are predominantly cuboidal with scant, clear to pale, acidophilic cytoplasms and low-grade nucleolar features (Ferlicot et al. 2005).
Fig. 1

Elongated tubules in a background myxoid stroma


The neoplastic cells are generally positive for CK7 and AMACR.

Molecular Features

Data regarding mucinous tubular and spindle cell carcinoma indicate various chromosomal losses and gains but no loss of 3p or trisomy 7 and/or trisomy 17 (Cossu-Rocca et al. 2006).

Differential Diagnosis

Papillary renal cell carcinoma is the most important differential diagnosis. Due to the overlapping immunophenotype, FISH analysis is the most reliable tool in the routine diagnostic workup.

References and Further Reading

  1. Cossu-Rocca, P., Eble, J. N., Delahunt, B., et al. (2006). Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinoma. Modern Pathology, 19, 488–493.CrossRefGoogle Scholar
  2. Ferlicot, S., Allory, Y., Compérat, E., et al. (2005). Mucinous tubular and spindle cell carcinoma: A report of 15 cases and a review of the literature. Virchows Archiv, 447, 978–983.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Diagnostic and Public Health, Section of PathologyUniversity of VeronaVeronaItaly
  2. 2.Department of PathologyPederzoli HospitalPeschiera del GardaItaly