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Encyclopedia of Pathology pp 1–2Cite as

Renal Mixed Epithelial and Stromal Tumor

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Cystic hamartoma of renal pelvis and adult mesoblastic nephroma

Definition

Renal mixed epithelial and stromal tumor is an uncommon complex biphasic neoplasm which occurs in adults.

Clinical Features

  • Incidence

    The tumor comprises less than 1% of all renal neoplasms.

  • Age

    The mean age is around 50 years.

  • Sex

    There is a striking female predominance. The tumors are related to hormonal factors (Adsay et al. 2000).

  • Site

    There is no site predominance.

  • Treatment

    It is typically cured by nephrectomy.

  • Outcome

    Renal mixed epithelial and stromal tumor is an indolent tumor, although malignant transformation has been reported with a morphology resembling stromal sarcoma and carcinosarcoma (Svec et al. 2001).

Macroscopy

The tumor is a solid or solid and cystic mass.

Microscopy

It is mainly composed of stroma with a variable amount of cysts. The stromal component varied from paucicellular fibrous tissue to markedly cellular areas sometimes resembling ovarian stroma. Condensation of...

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References and Further Readings

  • Adsay, N. V., Eble, J. N., Srigley, J. R., et al. (2000). Mixed epithelial and stromal tumor of the kidney. The American Journal of Surgical Pathology, 24, 958–970.

    Article  CAS  Google Scholar 

  • Caliò, A., Eble, J. N., Grignon, D. J., & Delahunt, B. (2016). Mixed epithelial and stromal tumor of the kidney: A Clinicopathologic Study of 53 cases. The American Journal of Surgical Pathology, 40, 1538–1549.

    Article  Google Scholar 

  • Moch, H., Humprey, PA., Ulbright, TM., et al. (2016) WHO Classification of Tumours of the Urinary System and Male Genital Organs. Lyon.

    Google Scholar 

  • Svec, A., Hes, O., Michal, M., et al. (2001). Malignant mixed epithelial and stromal tumor of the kidney. Virchows Archive, 439, 700–702.

    Article  CAS  Google Scholar 

  • Turbiner, J., Amin, M. B., Humphrey, P. A., et al. (2007). Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. The American Journal of Surgical Pathology, 31, 489–500.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Diagnostic and Public Health, Section of Pathology, University of Verona, Verona, Italy

    Anna Caliò & Guido Martignoni

  2. Department of Pathology, Pederzoli Hospital, Peschiera del Garda, Italy

    Diego Segala & Guido Martignoni

Authors
  1. Anna Caliò
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  2. Diego Segala
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  3. Guido Martignoni
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Corresponding author

Correspondence to Guido Martignoni .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cite this entry

Caliò, A., Segala, D., Martignoni, G. (2019). Renal Mixed Epithelial and Stromal Tumor. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4925-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4925-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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