Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Renal Mixed Epithelial and Stromal Tumor

  • Anna Caliò
  • Diego Segala
  • Guido MartignoniEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4925-1

Synonyms

Definition

Renal mixed epithelial and stromal tumor is an uncommon complex biphasic neoplasm which occurs in adults.

Clinical Features

  • Incidence

    The tumor comprises less than 1% of all renal neoplasms.

  • Age

    The mean age is around 50 years.

  • Sex

    There is a striking female predominance. The tumors are related to hormonal factors (Adsay et al. 2000).

  • Site

    There is no site predominance.

  • Treatment

    It is typically cured by nephrectomy.

  • Outcome

    Renal mixed epithelial and stromal tumor is an indolent tumor, although malignant transformation has been reported with a morphology resembling stromal sarcoma and carcinosarcoma (Svec et al. 2001).

Macroscopy

The tumor is a solid or solid and cystic mass.

Microscopy

It is mainly composed of stroma with a variable amount of cysts. The stromal component varied from paucicellular fibrous tissue to markedly cellular areas sometimes resembling ovarian stroma. Condensation of...
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References and Further Readings

  1. Adsay, N. V., Eble, J. N., Srigley, J. R., et al. (2000). Mixed epithelial and stromal tumor of the kidney. The American Journal of Surgical Pathology, 24, 958–970.CrossRefGoogle Scholar
  2. Caliò, A., Eble, J. N., Grignon, D. J., & Delahunt, B. (2016). Mixed epithelial and stromal tumor of the kidney: A Clinicopathologic Study of 53 cases. The American Journal of Surgical Pathology, 40, 1538–1549.CrossRefGoogle Scholar
  3. Moch, H., Humprey, PA., Ulbright, TM., et al. (2016) WHO Classification of Tumours of the Urinary System and Male Genital Organs. Lyon.Google Scholar
  4. Svec, A., Hes, O., Michal, M., et al. (2001). Malignant mixed epithelial and stromal tumor of the kidney. Virchows Archive, 439, 700–702.CrossRefGoogle Scholar
  5. Turbiner, J., Amin, M. B., Humphrey, P. A., et al. (2007). Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. The American Journal of Surgical Pathology, 31, 489–500.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Diagnostic and Public Health, Section of PathologyUniversity of VeronaVeronaItaly
  2. 2.Department of PathologyPederzoli HospitalPeschiera del GardaItaly