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Renal Mixed Epithelial and Stromal Tumor

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Cystic hamartoma of renal pelvis and adult mesoblastic nephroma

Definition

Renal mixed epithelial and stromal tumor is an uncommon complex biphasic neoplasm which occurs in adults.

Clinical Features

  • Incidence

    The tumor comprises less than 1% of all renal neoplasms.

  • Age

    The mean age is around 50 years.

  • Sex

    There is a striking female predominance. The tumors are related to hormonal factors (Adsay et al. 2000).

  • Site

    There is no site predominance.

  • Treatment

    It is typically cured by nephrectomy.

  • Outcome

    Renal mixed epithelial and stromal tumor is an indolent tumor, although malignant transformation has been reported with a morphology resembling stromal sarcoma and carcinosarcoma (Svec et al. 2001).

Macroscopy

The tumor is a solid or solid and cystic mass.

Microscopy

It is mainly composed of stroma with a variable amount of cysts. The stromal component varied from paucicellular fibrous tissue to markedly cellular areas sometimes resembling ovarian stroma. Condensation of...

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References and Further Readings

  • Adsay, N. V., Eble, J. N., Srigley, J. R., et al. (2000). Mixed epithelial and stromal tumor of the kidney. The American Journal of Surgical Pathology, 24, 958–970.

    Article  CAS  Google Scholar 

  • Caliò, A., Eble, J. N., Grignon, D. J., & Delahunt, B. (2016). Mixed epithelial and stromal tumor of the kidney: A Clinicopathologic Study of 53 cases. The American Journal of Surgical Pathology, 40, 1538–1549.

    Article  Google Scholar 

  • Moch, H., Humprey, PA., Ulbright, TM., et al. (2016) WHO Classification of Tumours of the Urinary System and Male Genital Organs. Lyon.

    Google Scholar 

  • Svec, A., Hes, O., Michal, M., et al. (2001). Malignant mixed epithelial and stromal tumor of the kidney. Virchows Archive, 439, 700–702.

    Article  CAS  Google Scholar 

  • Turbiner, J., Amin, M. B., Humphrey, P. A., et al. (2007). Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. The American Journal of Surgical Pathology, 31, 489–500.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Diagnostic and Public Health, Section of Pathology, University of Verona, Verona, Italy

    Anna Caliò & Guido Martignoni

  2. Department of Pathology, Pederzoli Hospital, Peschiera del Garda, Italy

    Diego Segala & Guido Martignoni

Authors
  1. Anna Caliò
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  2. Diego Segala
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  3. Guido Martignoni
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Corresponding author

Correspondence to Guido Martignoni .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cite this entry

Caliò, A., Segala, D., Martignoni, G. (2019). Renal Mixed Epithelial and Stromal Tumor. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4925-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4925-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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