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Encyclopedia of Pathology pp 1–2Cite as

Penile Mixed Squamous Cell Carcinoma

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Part of the book series: Encyclopedia of Pathology ((EP))

Definition

Penile mixed carcinomas harbor more than one histologic subtype and each of the subtypes should make up at least 20% of the tumor mass.

Clinical Features

  • Incidence

    Their frequency ranges between 20% and 33% of all penile carcinomas.

  • Age

    Tumors affect patients in the 7th decade.

  • Sex

    Male.

  • Site

    Most of these tumors are located in the glans. Foreskin location is rare.

  • Treatment

    Penectomy.

  • Outcome

    Prognosis is related to relative proportion of different components and the presence of higher histologic grade. Recurrences are present in about 20% of cases. Regional nodal metastases are rare (9%). Mixed carcinoma with component of verrucous carcinoma occasionally presents lymph node metastases, which explains the presence of metastatic cases otherwise never reported in true verrucous carcinoma. The mortality rate is low (3%) and the selection of treatment (conservative versus radical with or without groin dissection) requires careful histologic grading and assessment of perineural...

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References and Further Reading

  • Chaux, A., Tamboli, P., Ayala, A., Soares, F., Rodríguez, I., Barreto, J., & Cubilla, A. L. (2010). Warty-basaloid carcinoma: Clinicopathological features of a distinctive penile neoplasm. Report of 45 cases. Modern Pathology, 23(6), 896–904.

    Article  Google Scholar 

  • Kato, N., Onozuka, T., Yasukawa, K., Kimura, K., & Sasaki, K. (2000). Penile hybrid verrucous-squamous carcinoma associated with a superficial inguinal lymph node metastasis. The American Journal of Dermatopathology, 22(4), 339–343.

    Article  CAS  Google Scholar 

  • Velazquez, E. F., Ayala, G., Liu, H., Chaux, A., Zanotti, M., Torres, J., Cho, S. I., Barreto, J. E., Soares, F., & Cubilla, A. L. (2008). Histologic grade and perineural invasion are more important than tumor thickness as predictor of nodal metastasis in penile squamous cell carcinoma invading 5 to 10 mm. The American Journal of Surgical Pathology, 32(7), 974–979.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Uropathology Unit, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Maurizio Colecchia

  2. Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Alessia Bertolotti

Authors
  1. Maurizio Colecchia
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  2. Alessia Bertolotti
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Corresponding author

Correspondence to Maurizio Colecchia .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cite this entry

Colecchia, M., Bertolotti, A. (2019). Penile Mixed Squamous Cell Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4884-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4884-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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