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Condyloma and Condyloma Acuminatum

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Benign condyloma; Genital wart; Usual condyloma

Definition

HPV-related exophytic papillomatous epithelial proliferation (Calonje 2011).

Clinical Features

  • Incidence

    Median of 200 affected patients per 100,000 inhabitants (male and female) (Patel et al. 2013).

  • Age

    Sexually active young adults (3rd–4thdecade), rare in older patients.

  • Sex

    Male and female adults.

  • Etiology

    Most cases (85%) are related to low-risk HPV genotypes 6 and 11. High risk genotypes (16, 18, and others) are more common in patients with multiple sexual partners.

  • Site

    Glans, coronal sulcus, foreskin, meatus, scrotum (men), and even urethra or urinary bladder (men and women) for direct extension.

  • Treatment

    Cryotherapy, laser therapy, or local surgical excision for small circumscribed lesions. Extensive surgery is required for giant destructive condylomas.

  • Outcome

    Good but recurrence is not uncommon, especially for individuals with multiple sexual partners (Thomas et al. 2017).

    Malignant transformation is very...

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References and Further Reading

  • Amin, M. B. (2016). Diagnostic pathology: Genitourinary. Philadelphia: Elsevier.

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  • Botella, E., Burgués, O., et al. (2000). Warty carcinoma arising in condyloma acuminatum of urinary bladder: A case report. International Journal of Surgical Pathology, 8(3), 253–259.

    Article  Google Scholar 

  • Calonje, E. (2011). Mckee’s pathology of the skin. Amsterdam: Elsevier.

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  • Patel, H., Wagner, M., et al. (2013). Systematic review of the incidence and prevalence of genital warts. BMC Infectious Diseases, 13, 39–39.

    Article  Google Scholar 

  • Thomas, R., Steben, M., et al. (2017). Recurrence of human papillomavirus external genital wart infection among high-risk adults in Montréal, Canada. Sexually Transmitted Diseases, 44(11), 700–706.

    Article  Google Scholar 

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Correspondence to Maria Rosaria Raspollini .

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Fattorini, C., Lopez-Beltran, A., Raspollini, M.R. (2019). Condyloma and Condyloma Acuminatum. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4793-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4793-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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