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Calcifying Nodules

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Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Scrotum: Idiopathic calcinosis of scrotum; Testis: Nodular proliferation of calcifying connective tissue

Definition

Benign condition characterized by presence of single or multiple calcified nodules.

Clinical Features

  • Incidence

    Uncommon condition.

  • Age

    Children and young adults.

  • Sex

    Males.

  • Site

    Skin of scrotum, testis, and paratesticular structures.

  • Presentation

    • Scrotum: Single or multiple mobile masses affecting the skin of this region.

    • Testis: Single palpable mass of varying size near the pole of the organ.

  • Treatment

    • Scrotum: Surgical excision of the symptomatic nodules is sufficient (Khallouk et al. 2011).

    • Testis: Due to the undefined diagnosis before the final histopathologic examination, a partial orchiectomy is frequently performed (Akdemir et al. 2017).

  • Outcome

    Calcifying nodules are benign lesions and the prognosis after excision is excellent.

Macroscopy

Well-circumscribed yellowish nodules, rarely pedunculated (Gi et al. 2008).

Microscopy

Scrotum: Granular and globular...

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References and Further Reading

  • Akdemir, F., Aldemir, M., & Orhun, H. S. (2017). Intratesticular calcified nodule. Turkish Journal of Urology, 43, 563–565.

    Article  Google Scholar 

  • Gi, N., Gupta, A. K., Sachi, K., & Thomas, S. (2008). Idiopathic scrotal calcinosis; a pedunculated rare variant. Journal of Plastic, Reconstructive & Aesthetic Surgery, 61, 466–467.

    Article  Google Scholar 

  • Khallouk, A., Yazami, O. E., Mellas, S., Tazi, M. F., El Fassi, J., & Farih, M. H. (2011). Idiopathic scrotal calcinosis: A non-elucidated pathogenesis and its surgical treatment. Reviews in Urology, 13, 95–97.

    PubMed  PubMed Central  Google Scholar 

  • Nistal, M., & Paniagua, R. (1989). Nodular proliferation of calcifying connective tissue in the rete testis: A study of three cases. Human Pathology, 20, 58–61.

    Article  CAS  Google Scholar 

  • Song, D. H., Lee, K. H., & Kang, W. H. (1988). Idiopathic calcinosis of the scrotum: Histopathologic observations of fifty-one nodules. Journal of the American Academy of Dermatology, 19, 1095–1101.

    Article  CAS  Google Scholar 

  • Swinehart, J. M., & Golitz, L. E. (1982). Scrotal calcinosis: Dystrophic calcification of epidermoid cysts. Archives of Dermatology, 118, 985–988.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Caterina Fattorini & Maria Rosaria Raspollini

  2. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  3. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

Authors
  1. Caterina Fattorini
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  2. Antonio Lopez-Beltran
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  3. Maria Rosaria Raspollini
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Corresponding author

Correspondence to Maria Rosaria Raspollini .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Fattorini, C., Lopez-Beltran, A., Raspollini, M.R. (2019). Calcifying Nodules. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4788-2

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4788-2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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Chapter history

  1. Latest

    Calcifying Nodules
    Published:
    19 July 2019

    DOI: https://doi.org/10.1007/978-3-319-28845-1_4788-2

  2. Original

    Calcifying Nodules
    Published:
    02 May 2019

    DOI: https://doi.org/10.1007/978-3-319-28845-1_4788-1

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