Definition
Microinvasive carcinoma (MIC) of the breast was not clearly characterized until 1997 when the Union for International Cancer Control (UICC) first included pT1mic in the TNM classification of breast carcinoma. It was defined as “invasive mammary carcinoma with no focus exceeding 1 mm in greatest dimension.”
This definition has been carried through many editions of the Cancer Staging Manual published by American Joint Committee on Cancer (AJCC) until the current edition (Amin et al. 2017) where it is reported as “an invasive carcinoma with no focus measured larger than 1 mm and classified as pT1mi. MIC is reported as nearly always encountered in a setting of ductal carcinoma in situ (DCIS) (Ductal Carcinoma In Situ) (Fig. 1, (a) H&E. A duct with high-grade DCIS and a small area (<1 mm) of irregular nests of invasive cancer surrounded by a mononuclear cell infiltrate....
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References and Further Reading
Amin, M. B., Edge, S. B., Greene, F. L., et al. (Eds.). (2017). AJCC cancer staging manual (8th ed.pp. 589–628). New York: Springer.
Bianchi, S., & Vezzosi V. (2008). Microinvasive Carcinoma of the Breast. Pathology and Oncology Research, 14, 105–111.
Cserni, G., Wells, C. A., Kaia, H., et al. (2016). Consistency in recognizing microinvasion in breast carcinomas is improved by immunohistochemistry for myoepithelial markers. Virchows Archive, 468, 473–481.
Hilson, J. B., Schnitt, S. J., & Collins, L. C. (2009). Phenotypic alterations in ductal carcinoma in situ-associated myoepithelial cells: Biologic and diagnostic implications. The American Journal Surgical Pathology, 33, 227–232.
Hoda, S. A. (2014). Ductal carcinoma in situ. In S. A. Hoda, E. Brogi, F. C. Koerner, & P. P. Rosen (Eds.), Rosen’s breast pathology (4th ed., pp. 331–411). Philadelphia: Lippincott Williams & Wilkins.
Morita, M., Yamaguchi, R., Tanaka, M., et al. (2016). Two progressive pathways of microinvasive carcinoma: Low-grade luminal pathway and high grade HER2 pathway based on high tumor-infiltrating lymphocytes. Journal of Clinical Pathology, 69, 890–898.
Pinder, S. E., Ellis, I. O., Schnitt, S. J., et al. (2012). Microinvasive carcinoma. In S. R. Lakhani, I. O. Ellis, S. J. Schnitt, et al. (Eds.), WHO classification of tumours of the breast (pp. 96–97). Lyon: International Agency for Research on Cancer.
Schnitt, S. J., & Collins, L. C. (Eds.). (2013). Biopsy interpretation of the breast (2nd ed.pp. 267–281). Philadelphia: Lippincott Williams & Wilkins.
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Bianchi, S., Vezzosi, V. (2019). Microinvasive Carcinoma of the Breast. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4765-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4765-1
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