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Hormone Receptors in Breast Cancer

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  • Aleskandarany, M. A., Abduljabbar, R., Ashankyty, I., Elmouna, A., Jerjees, D., Ali, S., Buluwela, L., Diez-Rodriguez, M., Caldas, C., Green, A. R., Ellis, I. O., & Rakha, E. A. (2016). Prognostic significance of androgen receptor expression in invasive breast cancer: Transcriptomic and protein expression analysis. Breast Cancer Research and Treatment, 159, 215–227.

    Article  CAS  PubMed  Google Scholar 

  • Castellano, I., Chiusa, L., Vandone, A. M., Beatrice, S., Goia, M., Donadio, M., Arisio, R., Muscara, F., Durando, A., Viale, G., Cassoni, P., & Sapino, A. (2013). A simple and reproducible prognostic index in luminal ER-positive breast cancers. Annals of Oncology, 24, 2292–2297.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gahlaut, R., Bennett, A., Fatayer, H., Dall, B. J., Sharma, N., Velikova, G., Perren, T., Dodwell, D., Lansdown, M., & Shaaban, A. M. (2016). Effect of neoadjuvant chemotherapy on breast cancer phenotype, ER/PR and HER2 expression – Implications for the practising oncologist. European Journal of Cancer, 60, 40–48.

    Article  CAS  PubMed  Google Scholar 

  • Guidelines Working Group of the UK National Coordinating Committee for Breast Pathology. (2016). Pathology reporting of breast disease in surgical excision specimens incorporating the dataset for histological reporting of breast cancer. London: The Royal College of Pathologists.

    Google Scholar 

  • Hammond ME, Hayes DF, Wolff AC, Mangu PB, Temin S. American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J Oncol Pract. 2010 Jul;6(4):195–7. https://doi.org/10.1200/JOP.777003

    Article  PubMed  PubMed Central  Google Scholar 

  • Harvey, J. M., Clark, G. M., Osborne, C. K., & Allred, D. C. (1999). Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. Journal of Clinical Oncology, 17, 1474–1481.

    Article  CAS  PubMed  Google Scholar 

  • Hodi, Z., Chakrabarti, J., Lee, A. H., Ronan, J. E., Elston, C. W., Cheung, K. L., Robertson, J. F., & Ellis, I. O. (2007). The reliability of assessment of oestrogen receptor expression on needle core biopsy specimens of invasive carcinomas of the breast. Journal of Clinical Pathology, 60, 299–302.

    Article  PubMed  Google Scholar 

  • Howell, A., Cuzick, J., Baum, M., Buzdar, A., Dowsett, M., Forbes, J. F., Hoctin-Boes, G., Houghton, J., Locker, G. Y., Tobias, J. S., & A. T. Group. (2005). Results of the ATAC (Arimidex, tamoxifen, alone or in combination) trial after completion of 5 years’ adjuvant treatment for breast cancer. Lancet, 365, 60–62.

    Article  CAS  PubMed  Google Scholar 

  • Humphries, M. P., Sundara Rajan, S., Honarpisheh, H., Cserni, G., Dent, J., Fulford, L., Jordan, L. B., Jones, J. L., Kanthan, R., Litwiniuk, M., Di Benedetto, A., Mottolese, M., Provenzano, E., Shousha, S., Stephens, M., Kulka, J., Ellis, I. O., Titloye, A. N., Hanby, A. M., Shaaban, A. M., & Speirs, V. (2017). Characterisation of male breast cancer: A descriptive biomarker study from a large patient series. Scientific Reports, 7, 45293.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee, A. V., Cui, X., & Oesterreich, S. (2001). Cross-talk among estrogen receptor, epidermal growth factor, and insulin-like growth factor signaling in breast cancer. Clinical Cancer Research, 7(12 Suppl), 4429s–4435s; discussion 4411s–4412s.

    PubMed  CAS  Google Scholar 

  • Levin, E. R., & Hammes, S. R. (2016). Nuclear receptors outside the nucleus: Extranuclear signalling by steroid receptors. Nature Reviews Molecular Cell Biology, 17, 783–797.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu, J., Guo, H., Mao, K., Zhang, K., Deng, H., & Liu, Q. (2016). Impact of estrogen receptor-beta expression on breast cancer prognosis: A meta-analysis. Breast Cancer Research and Treatment, 156, 149–162.

    Article  CAS  PubMed  Google Scholar 

  • Mote, P. A., Gompel, A., Howe, C., Hilton, H. N., Sestak, I., Cuzick, J., Dowsett, M., Hugol, D., Forgez, P., Byth, K., Graham, J. D., & Clarke, C. L. (2015). Progesterone receptor A predominance is a discriminator of benefit from endocrine therapy in the ATAC trial. Breast Cancer Research and Treatment, 151, 309–318.

    Article  CAS  PubMed  Google Scholar 

  • National Institute for Health and Care Excellence. (2009). Early and locally advanced breast cancer: Diagnosis and treatment, NICE guidelines [CG80]. Accessed 29 Dec 2017, from http://www.nice.org.uk/guidance/cg80.

  • Nemere, I., Pietras, R. J., & Blackmore, P. F. (2003). Membrane receptors for steroid hormones: Signal transduction and physiological significance. Journal of Cellular Biochemistry, 88, 438–445.

    Article  CAS  PubMed  Google Scholar 

  • Riemsma, R., Forbes, C. A., Kessels, A., Lykopoulos, K., Amonkar, M. M., Rea, D. W., & Kleijnen, J. (2010). Systematic review of aromatase inhibitors in the first-line treatment for hormone sensitive advanced or metastatic breast cancer. Breast Cancer Research and Treatment, 123, 9–24.

    Article  CAS  PubMed  Google Scholar 

  • Shaaban, A. M., Ball, G. R., Brannan, R. A., Cserni, G., Di Benedetto, A., Dent, J., Fulford, L., Honarpisheh, H., Jordan, L., Jones, J. L., Kanthan, R., Maraqa, L., Litwiniuk, M., Mottolese, M., Pollock, S., Provenzano, E., Quinlan, P. R., Reall, G., Shousha, S., Stephens, M., Verghese, E. T., Walker, R. A., Hanby, A. M., & Speirs, V. (2012). A comparative biomarker study of 514 matched cases of male and female breast cancer reveals gender-specific biological differences. Breast Cancer Research and Treatment, 133, 949–958.

    Article  CAS  PubMed  Google Scholar 

  • van de Ven, S., Smit, V. T., Dekker, T. J., Nortier, J. W., & Kroep, J. R. (2011). Discordances in ER, PR and HER2 receptors after neoadjuvant chemotherapy in breast cancer. Cancer Treatment Reviews, 37, 422–430.

    PubMed  Google Scholar 

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Correspondence to Abeer M. Shaaban .

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Shaaban, A.M., Speirs, V. (2018). Hormone Receptors in Breast Cancer. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4754-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4754-1

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