Pseudoangiomatous Stromal Hyperplasia
Nodular myofibroblastic stromal hyperplasia of the mammary gland (Leon et al. 2002).
Pseudoangiomatous hyperplasia of mammary stroma (PASH) is a benign proliferation of keloid-like fibrosis, containing slit-like pseudovascular spaces lined by spindle shaped cells without mitotic figures and atypia. (Ibrahim et al. 1989). PASH is considered a breast-specific myofibroblastic proliferation (Krings et al. 2017.
PASH of the breast was first described by Vuitch et al. in 1986 (Vuitch et al. 1986). Its incidence was later investigated in a series of 200 consecutive breast biopsies and surgical specimens and was found to be an incidental finding in breast biopsies in 23% of the cases (Ibrahim et al. 1989). Incidental PASH can be found in fibroadenomas, gynecomastia, normal breast tissue, hamartomas, and sclerosing lobular hyperplasia. It has also been described in surgical specimens of gigantomastia. Two cases were described in immunosuppressed...
References and Further Reading
- de Saint Aubain Somerhausen, N., Larsimont, D., Cluydts, N., Heymans, O., & Verhest, A. (1997). Pseudoangiomatous hyperplasia of mammary stroma in an HIV patient. General & Diagnostic Pathology, 143, 251–254.Google Scholar
- Noda, Y., Nishimae, A., Sawai, Y., Inaji, H., & Yamasaki, M. (2019). Atypical pseudoangiomatous stromal hyperplasia showing rapid growth of the breast: Report of a case. Pathology International. https://doi.org/10.1111/pin.12786.
- Pellini, D. F., Lorenzi, M., Gaudino, R., Accordini, B., Mirandola, S., Invento, A., & Pollini, P. D. (2018). Pseudoangiomatous stromal hyperplasia (PASH) in adolescence: A systematic review. World Journal of Surgery and Surgical Research, 1, 1058.Google Scholar
- Raj, S. D., Sahani, V. G., Adrada, B. E., Scoggins, M. E., Albarracin, C. T., Woodtichartpreecha, P., Posleman Monetto, F. E., & Whitman, G. J. (2017). Pseudoangiomatous stromal hyperplasia of the breast: Multimodality review with pathologic correlation. Current Problems in Diagnostic Radiology, 46, 130–135.CrossRefGoogle Scholar
- Recavarren R. A., Chivukula M., Carter G., Dabbs D. J. (2009). Columnar cell lesions and pseudoangiomatous hyperplasia like stroma: is there an epithelial-stromal interaction? International Journal of Clinical and Experimental Pathology, 3, 87–97.Google Scholar
- Rosen, P. P. (2001). Rosen’s breast pathology. Philadelphia: Lippincott Williams & Wilkins.Google Scholar