Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Pseudoangiomatous Stromal Hyperplasia

  • Janina KulkaEmail author
  • Anna Sapino
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4728-1


Nodular myofibroblastic stromal hyperplasia of the mammary gland (Leon et al. 2002).


Pseudoangiomatous hyperplasia of mammary stroma (PASH) is a benign proliferation of keloid-like fibrosis, containing slit-like pseudovascular spaces lined by spindle shaped cells without mitotic figures and atypia. (Ibrahim et al. 1989). PASH is considered a breast-specific myofibroblastic proliferation (Krings et al. 2017.

Clinical Features

  • Incidence

    PASH of the breast was first described by Vuitch et al. in 1986 (Vuitch et al. 1986). Its incidence was later investigated in a series of 200 consecutive breast biopsies and surgical specimens and was found to be an incidental finding in breast biopsies in 23% of the cases (Ibrahim et al. 1989). Incidental PASH can be found in fibroadenomas, gynecomastia, normal breast tissue, hamartomas, and sclerosing lobular hyperplasia. It has also been described in surgical specimens of gigantomastia. Two cases were described in immunosuppressed...

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References and Further Reading

  1. Bowman, E., Oprea, G., Okoli, J., Gundry, K., Rizzo, M., Gabram-Mendola, S., Manne, U., Smith, G., Pambuccian, S., & Bumpers, H. L. (2012). Pseudoangiomatous stromal hyperplasia (PASH) of the breast: A series of 24 patients. The Breast Journal, 18, 242–247.CrossRefGoogle Scholar
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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.2nd Department of PathologySemmelweis UniversityBudapestHungary
  2. 2.Unit of PathologyCandiolo Cancer Institute FPO-IRCCSCandioloItaly
  3. 3.Department of Medical SciencesUniversity of TorinoTurinItaly