Skip to main content
SpringerLink
Log in

Lobular In Situ Neoplasia

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 160 Accesses

Synonyms

Lobular carcinoma in situ (LCIS); Lobular intraepithelial neoplasia (LIN)

Definition

Lobular carcinoma in situ (LCIS) is characterized by a neoplastic proliferation of small, uniform, dyscohesive cells that expands at least 50% of one terminal ductal-lobular unit (TDLU). Although the first pictures of “atypical proliferation of acinar cells” were published in 1919 by Ewing, the term LCIS was introduced in 1941 by Foote and Stewart to describe the histological hallmarks of this lesion within breast lobules. The description was restricted to a well-developed example of classic LCIS (LCIS-C) as an established histopathological entity. In 1985, Dupont and Page described the earlier stages of this lesion, such as atypical lobular hyperplasia (ALH). The term lobular neoplasia (LN) denotes the full spectrum of proliferation of the characteristic “lobular” cells in acini with frequent coexistence of ALH and LCIS (Haagensen et al. 1978). Additionally, the lobular neoplastic lesions...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References and Further Reading

  • Haagensen, C. D., Lane, N., Lattes, R., & Bodian, C. (1978). Lobular neoplasia (so-called lobular carcinoma in situ) of the breast. Cancer, 42, 737–769.

    Article  CAS  PubMed  Google Scholar 

  • King, T. A., Pilewskie, M., Muhsen, S., Patil, S., Mautner, S. K., Park, A., Oskar, S., Guerini-Rocco, E., Boafo, C., Gooch, J. C., De Brot, M., Reis-Filho, J. S., Morrogh, M., Andrade, V. P., Sakr, R. A., & Morrow, M. (2015). Lobular carcinoma in situ: A 29-year longitudinal experience evaluating clinicopathologic features and breast cancer risk. Journal of Clinical Oncology, 33, 3945–3952.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mastracci, T. L., Tjan, S., Bane, A. L., O’malley, F. P., & Andrulis, I. L. (2005). E-cadherin alterations in atypical lobular hyperplasia and lobular carcinoma in situ of the breast. Modern Pathology, 18, 741–751.

    Article  CAS  PubMed  Google Scholar 

  • Pieri, A., Harvey, J., & Bundred, N. (2014). Pleomorphic lobular carcinoma in situ of the breast: Can the evidence guide practice? World Journal of Clinical Oncology, 5, 546–553.

    Article  PubMed  PubMed Central  Google Scholar 

  • Simpson, P. T., Reis-Filho, J. S., Gale, T., & Lakhani, S. R. (2005). Molecular evolution of breast cancer. Journal of Pathology, 205, 248–254.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division for Laboratory medicine, Department of Pathology, Lund University, Lund, Sweden

    Gyula Pekar

Authors
  1. Gyula Pekar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gyula Pekar .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Pekar, G. (2018). Lobular In Situ Neoplasia. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4722-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4722-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation