Synonyms
Definition
Invasive micropapillary carcinoma (IMPC) is a special type of invasive breast carcinoma (IBC) characterized by cancer cells with eosinophilic or granular cytoplasm, forming morule-like clusters, surrounded by clear stromal spaces. Tumor cells have characteristic reverse polarity, also known as an “inside-out” growth pattern: the apical pole of tumor cells faces the empty stromal spaces.
Clinical Features
Incidence: Pure IMPC is a rare subtype of invasive breast cancer, accounting in its pure form for 0.9–2% of IBCs. The reported incidence of IBC with a micropapillary component is up to 8%.
Age: The reported median age of IMPC is from 48 to 62 years, consistent with that of patients with estrogen receptor (ER) positive IBC.
Sex: IMPC usually affects women, but single cases of male IMPC had been reported. In studies on male breast cancer, the reported incidence of IBC with micropapillary features varies between 0% and 11%.
Site: No specific...
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References and Further Reading
Chen, A. C., Paulino, A. C., Schwartz, M. R., Rodriguez, A. A., Bass, B. L., Chang, J. C., & Teh, B. S. (2014). Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast. British Journal of Cancer, 111, 619–622.
Fisher, E. R., Palekar, A. S., Redmond, C., Barton, B., & Fisher, B. (1980). Pathologic findings from the National Surgical Adjuvant Breast Project (protocol no. 4). VI. Invasive papillary cancer. American Journal of Clinical Pathology, 73, 313–322.
Gruel, N., Benhamo, V., Bhalshankar, J., Popova, T., Freneaux, P., Arnould, L., Mariani, O., Stern, M. H., Raynal, V., Sastre-Garau, X., Rouzier, R., Delattre, O., & Vincent-Salomon, A. (2014). Polarity gene alterations in pure invasive micropapillary carcinomas of the breast. Breast Cancer Research, 16, R46. https://doi.org/10.1186/bcr3653
Lee, A. H., Paish, E. C., Marchio, C., Sapino, A., Schmitt, F. C., Ellis, I. O., & Reis-Filho, J. S. (2007). The expression of Wilms’ tumour-1 and Ca125 in invasive micropapillary carcinoma of the breast. Histopathology, 51(6), 824–828.
Li, S., Yang, C., Zhai, L., Zhang, W., Yu, J., Gu, F., Lang, R., Fan, Y., Gong, M., Zhang, X., & Fu, L. (2012). Deep sequencing reveals small RNA characterization of invasive micropapillary carcinomas of the breast. Breast Cancer Research and Treatment, 136(1), 77–87.
Marchiò, C., Iravani, M., Natrajan, R., Lambros, M. B., Savage, K., Tamber, N., Fenwick, K., Mackay, A., Senetta, R., Di Palma, S., Schmitt, F. C., Bussolati, G., Ellis, I. O., Ashworth, A., Sapino, A., & Reis-Filho, J. S. (2008). Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast. The Journal of Pathology, 215, 398–410.
Marchiò, C., Iravani, M., Natrajan, R., Lambros, M. B., Geyer, F. C., Savage, K., Parry, S., Tamber, N., Fenwick, K., Mackay, A., Schmitt, F. C., Bussolati, G., Ellis, I., Ashworth, A., Sapino, A., & Reis-Filho, J. S. (2009). Mixed micropapillary-ductal carcinomas of the breast: A genomic and immunohistochemical analysis of morphologically distinct components. The Journal of Pathology, 218(3), 301–315.
Natrajan, R., Wilkerson, P. M., Marchiò, C., Piscuoglio, S., Ng, C. K., Wai, P., Lambros, M. B., Samartzis, E. P., Dedes, K. J., Frankum, J., Bajrami, I., Kopec, A., Mackay, A., A’Hern, R., Fenwick, K., Kozarewa, I., Hakas, J., Mitsopoulos, C., Hardisson, D., Lord, C. J., Kumar-Sinha, C., Ashworth, A., Weigelt, B., Sapino, A., Chinnaiyan, A. M., Maher, C. A., & Reis-Filho, J. S. (2014). Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast. The Journal of Pathology, 232(5), 553–565.
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Siriaunkgul, S., & Tavassoli, F. A. (1993). Invasive micropapillary carcinoma of the breast. Modern Pathology, 6, 660–662.
Wang, X. X., Liu, B. B., Wu, X., Su, D., Zhu, Z., & Fu, L. (2015). Loss of leucine zipper putative tumor suppressor 1 (LZTS1) expression contributes to lymph node metastasis of breast invasive micropapillary carcinoma. Pathology Oncology Research: POR, 21(4), 1021–1026.
Weigelt, B., Horlings, H. M., Kreike, B., Hayes, M. M., Hauptmann, M., Wessels, L. F. A., de Jong, D., Van de Vijver, M. J., Van’t Veer, L. J., & Peterse, J. L. (2008). Refinement of breast cancer classification by molecular characterization of histological special types. The Journal of Pathology, 216, 141–150.
Yi-Ling, Y., Bing-Bing, L., Xinmin, Z., & Li, F. (2016). Invasive micropapillary carcinoma of the breast: An update. Archives of Pathology and Laboratory Medicine, 140, 799–805.
Yu, J. I., Choi, D. H., Huh, S. J., Cho, E. Y., Kim, K., Chie, E. K., Ha, S. W., Park, I. A., Ahn, S. J., Lee, J. S., Shin, K. H., Kwon, Y., Kim, Y. B., Suh, C. O., Koo, J. S., Kim, J. H., Jeong, B. G., Kim, I. A., Lee, J. H., & Park, W. (2015). Differences in prognostic factors and failure patterns between invasive micropapillary carcinoma and carcinoma with micropapillary component versus invasive ductal carcinoma of the breast: Retrospective Multicenter Case-Control Study (KROG 13-06). Clinical Breast Cancer, 15, 353-361.e351-352.
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Madaras, L., Kulka, J. (2018). Invasive Micropapillary Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4718-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4718-1
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