Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Invasive Micropapillary Carcinoma

  • Lilla Madaras
  • Janina Kulka
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4718-1



Invasive micropapillary carcinoma (IMPC) is a special type of invasive breast carcinoma (IBC) characterized by cancer cells with eosinophilic or granular cytoplasm, forming morule-like clusters, surrounded by clear stromal spaces. Tumor cells have characteristic reverse polarity, also known as an “inside-out” growth pattern: the apical pole of tumor cells faces the empty stromal spaces.

Clinical Features

  • Incidence: Pure IMPC is a rare subtype of invasive breast cancer, accounting in its pure form for 0.9–2% of IBCs. The reported incidence of IBC with a micropapillary component is up to 8%.

  • Age: The reported median age of IMPC is from 48 to 62 years, consistent with that of patients with estrogen receptor (ER) positive IBC.

  • Sex: IMPC usually affects women, but single cases of male IMPC had been reported. In studies on male breast cancer, the reported incidence of IBC with micropapillary features varies between 0% and 11%.

  • Site: No specific...

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References and Further Reading

  1. Chen, A. C., Paulino, A. C., Schwartz, M. R., Rodriguez, A. A., Bass, B. L., Chang, J. C., & Teh, B. S. (2014). Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast. British Journal of Cancer, 111, 619–622.CrossRefGoogle Scholar
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  3. Gruel, N., Benhamo, V., Bhalshankar, J., Popova, T., Freneaux, P., Arnould, L., Mariani, O., Stern, M. H., Raynal, V., Sastre-Garau, X., Rouzier, R., Delattre, O., & Vincent-Salomon, A. (2014). Polarity gene alterations in pure invasive micropapillary carcinomas of the breast. Breast Cancer Research, 16, R46.  https://doi.org/10.1186/bcr3653
  4. Lee, A. H., Paish, E. C., Marchio, C., Sapino, A., Schmitt, F. C., Ellis, I. O., & Reis-Filho, J. S. (2007). The expression of Wilms’ tumour-1 and Ca125 in invasive micropapillary carcinoma of the breast. Histopathology, 51(6), 824–828.CrossRefGoogle Scholar
  5. Li, S., Yang, C., Zhai, L., Zhang, W., Yu, J., Gu, F., Lang, R., Fan, Y., Gong, M., Zhang, X., & Fu, L. (2012). Deep sequencing reveals small RNA characterization of invasive micropapillary carcinomas of the breast. Breast Cancer Research and Treatment, 136(1), 77–87.CrossRefGoogle Scholar
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  7. Marchiò, C., Iravani, M., Natrajan, R., Lambros, M. B., Geyer, F. C., Savage, K., Parry, S., Tamber, N., Fenwick, K., Mackay, A., Schmitt, F. C., Bussolati, G., Ellis, I., Ashworth, A., Sapino, A., & Reis-Filho, J. S. (2009). Mixed micropapillary-ductal carcinomas of the breast: A genomic and immunohistochemical analysis of morphologically distinct components. The Journal of Pathology, 218(3), 301–315.CrossRefGoogle Scholar
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  11. Wang, X. X., Liu, B. B., Wu, X., Su, D., Zhu, Z., & Fu, L. (2015). Loss of leucine zipper putative tumor suppressor 1 (LZTS1) expression contributes to lymph node metastasis of breast invasive micropapillary carcinoma. Pathology Oncology Research: POR, 21(4), 1021–1026.CrossRefGoogle Scholar
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  13. Yi-Ling, Y., Bing-Bing, L., Xinmin, Z., & Li, F. (2016). Invasive micropapillary carcinoma of the breast: An update. Archives of Pathology and Laboratory Medicine, 140, 799–805.CrossRefGoogle Scholar
  14. Yu, J. I., Choi, D. H., Huh, S. J., Cho, E. Y., Kim, K., Chie, E. K., Ha, S. W., Park, I. A., Ahn, S. J., Lee, J. S., Shin, K. H., Kwon, Y., Kim, Y. B., Suh, C. O., Koo, J. S., Kim, J. H., Jeong, B. G., Kim, I. A., Lee, J. H., & Park, W. (2015). Differences in prognostic factors and failure patterns between invasive micropapillary carcinoma and carcinoma with micropapillary component versus invasive ductal carcinoma of the breast: Retrospective Multicenter Case-Control Study (KROG 13-06). Clinical Breast Cancer, 15, 353-361.e351-352.Google Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.2nd Department of PathologySemmelweis University BudapestBudapestHungary