Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Invasive Lobular Carcinoma

  • Maria P. Foschini
  • Luca Morandi
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4716-1


Invasive lobular carcinoma (ILC) is characterized by noncohesive cells, usually E-cadherin negative, that are dispersed or arranged in single-file linear pattern, but can show several additional architectural patterns (Tavassoli and Eusebi 2009; Lakhani et al. 2012). ILC is frequently associated with lobular carcinoma in situ (LCIS).

Clinical Features

  • Incidence: ILC is the second most common type of breast cancer and constitutes 5–15% of all invasive breast tumors (Lakhani et al. 2012), although incidence varies according to the criteria applied for diagnosis. The incidence of ILC is increasing, especially among postmenopausal women, probably as consequence of hormonal replacement therapy and alcohol abuse (Rakha and Ellis 2010).

  • Age: ILC usually affects peri and postmenopausal women aged 50 or more but it can be seen in a wide age range of patients, from young, in their third decade of life, to elderly women, aged more than 80 years (Tavassoli and Eusebi 2009).

  • Sex:ILC...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Biomedical and Neuromotor SciencesUniversity of Bologna, Unit of Anatomic Pathology at Bellaria HospitalBolognaItaly