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Invasive Carcinoma with Medullary Features

Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Atypical medullary carcinoma (atypical MC); Carcinoma with medullary features (CMF); Classical medullary carcinoma (classical MC); Invasive carcinoma of no special type (NST) with medullary characteristics

Definition

The WHO Classification of Tumors of the Breast recommends the use of the collective term “Carcinoma with Medullary Features” to encompass tumors previously diagnosed as classical medullary carcinoma (classical MC), atypical medullary carcinoma (atypical MC), and a subgroup of invasive breast carcinoma of no special type (NST) with medullary characteristics (Lakhani et al. 2012).

These tumors are characterized by the following histological features:

  1. 1.

    An expansile or pushing border

  2. 2.

    A syncytial growth pattern

  3. 3.

    High cytonuclear grade

  4. 4.

    A prominent lymphoplasmacytic infiltrate

These diagnostic criteria are less strict than the original criteria proposed by Ridolfi et al. for a diagnosis of classical MC which requires complete circumscription, a syncytial growth...

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References and Further Reading

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Author information

Authors and Affiliations

  1. Department of Histopathology , Irish National Breast Screening Programme and St. Vincent’s University Hospital, Dublin 4, Ireland

    Cecily Quinn & Clare D’Arcy

  2. School of Medicine, University College Dublin, Dublin, Ireland

    Cecily Quinn

Authors
  1. Cecily Quinn
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  2. Clare D’Arcy
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Corresponding author

Correspondence to Cecily Quinn .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Quinn, C., D’Arcy, C. (2018). Invasive Carcinoma with Medullary Features. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4714-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4714-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

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Chapter history

  1. Latest

    Invasive Carcinoma with Medullary Features
    Published:
    05 April 2018

    DOI: https://doi.org/10.1007/978-3-319-28845-1_4714-2

  2. Original

    Invasive Carcinoma with Medullary Features
    Published:
    07 February 2018

    DOI: https://doi.org/10.1007/978-3-319-28845-1_4714-1

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