Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Basaloid Carcinoma, Lung

  • Keith M KerrEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4349-1



A poorly differentiated malignant epithelial tumor that is considered a variant of squamous cell carcinoma. It has features (small cells, lobular architecture with peripheral palisading, high mitotic rate) shared with basal cell or basaloid carcinomas in other organs, e.g., skin and anal canal. Fully formed squamous features are absent, but the immunophenotype is consistently of squamous type. Tumors showing 50% of more of this histology, but with areas of typical squamous cell carcinoma, are still regarded as basaloid carcinoma. The term used in the WHO 2015 classification is basaloid squamous cell carcinoma.

Clinical Features

  • Incidence

    This is a rare tumor, perhaps accounting for 3–6% of cases in surgically resected series, but published data are confounded by variations in definition since the lesion was first described by Brambilla and colleagues in 1992. Until the publication of the...

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References and Further Reading

  1. Brambilla, E., Moro, D., Veale, D., et al. (1992). Basal cell (basaloid) carcinoma of the lung: A new morphologic and phenotypic entity with separate prognostic significance. Human Pathology, 23, 993–1003.CrossRefPubMedGoogle Scholar
  2. Brambilla, C. G., Laffaire, J., Lantuejoul, S., et al. (2014). Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity. Clinical Cancer Research, 20, 5777–5786.CrossRefPubMedGoogle Scholar
  3. Moro-Sibilot, D., Lantuejoul, S., Diab, S., et al. (2008). Lung carcinomas with a basaloid pattern: A study of 90 cases focusing on their poor prognosis. The European Respiratory Journal, 31, 854–859.CrossRefPubMedGoogle Scholar
  4. Wang, L. C., Wang, L., Kwauk, S., et al. (2011). Analysis on the clinical features of 22 basaloid squamous cell carcinoma of the lung. Journal of Cardiothoracic Surgery, 6, 10–15.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. N. (Eds.). (2015). WHO classification of tumours of the lung, pleura, thymus and heart. Geneva: WHO Press.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyAberdeen University Medical School, Aberdeen Royal InfirmaryAberdeenUK