Basaloid Carcinoma, Lung
A poorly differentiated malignant epithelial tumor that is considered a variant of squamous cell carcinoma. It has features (small cells, lobular architecture with peripheral palisading, high mitotic rate) shared with basal cell or basaloid carcinomas in other organs, e.g., skin and anal canal. Fully formed squamous features are absent, but the immunophenotype is consistently of squamous type. Tumors showing 50% of more of this histology, but with areas of typical squamous cell carcinoma, are still regarded as basaloid carcinoma. The term used in the WHO 2015 classification is basaloid squamous cell carcinoma.
This is a rare tumor, perhaps accounting for 3–6% of cases in surgically resected series, but published data are confounded by variations in definition since the lesion was first described by Brambilla and colleagues in 1992. Until the publication of the...
References and Further Reading
- Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. N. (Eds.). (2015). WHO classification of tumours of the lung, pleura, thymus and heart. Geneva: WHO Press.Google Scholar