Bone marrow is a semisolid tissue present in all the bones divided schematically into hematopoietically inactive fatty marrow, named yellow marrow, and hematopoietically active marrow, named red marrow. In adults, red marrow is mainly found in the central skeleton such as pelvis, sternum, skull, vertebra, scapulae, as well as epiphyseal areas of long bones such as femur and humerus.
The function of hematopoietic marrow is to regulate myeloid and lymphoid cell trafficking as well as hematopoietic stem and progenitor cell maintenance for normal myelopoiesis and lymphopoiesis. In addition, the marrow contains mesenchymal stem cells that can differentiate into adipocytes, hepatocytes, osteoblasts, chondrocytes, skeletal, and cardiac muscle cells. The nonhematopoietic marrow serves as a large store of reserve lipids. Bone marrow endothelial cells form a barrier preventing entry of red blood cells and platelets from the circulation regulating...
References and Further Reading
- Itkin, T., Gur-Cohen, S., Spencer, J. A., Schajnovitz, A., Ramasamy, S. K., Kusumbe, A. P., Ledergor, G., Jung, Y., Milo, I., Poulos, M. G., Kalinkovich, A., Ludin, A., Kollet, O., Shakhar, G., Butler, J. M., Rafii, S., Adams, R. H., Scadden, D. T., Lin, C. P., & Lapidot, T. (2016). Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature, 532, 323–328.CrossRefGoogle Scholar
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