Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Bone Marrow

  • Julie Bruneau
  • Chantal Brouzes
  • Vahid Asnafi
  • Thierry Jo MolinaEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_3875-1

Synonyms

Anatomy

Bone marrow is a semisolid tissue present in all the bones divided schematically into hematopoietically inactive fatty marrow, named yellow marrow, and hematopoietically active marrow, named red marrow. In adults, red marrow is mainly found in the central skeleton such as pelvis, sternum, skull, vertebra, scapulae, as well as epiphyseal areas of long bones such as femur and humerus.

Function

The function of hematopoietic marrow is to regulate myeloid and lymphoid cell trafficking as well as hematopoietic stem and progenitor cell maintenance for normal myelopoiesis and lymphopoiesis. In addition, the marrow contains mesenchymal stem cells that can differentiate into adipocytes, hepatocytes, osteoblasts, chondrocytes, skeletal, and cardiac muscle cells. The nonhematopoietic marrow serves as a large store of reserve lipids. Bone marrow endothelial cells form a barrier preventing entry of red blood cells and platelets from the circulation regulating...

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References and Further Reading

  1. Itkin, T., Gur-Cohen, S., Spencer, J. A., Schajnovitz, A., Ramasamy, S. K., Kusumbe, A. P., Ledergor, G., Jung, Y., Milo, I., Poulos, M. G., Kalinkovich, A., Ludin, A., Kollet, O., Shakhar, G., Butler, J. M., Rafii, S., Adams, R. H., Scadden, D. T., Lin, C. P., & Lapidot, T. (2016). Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature, 532, 323–328.CrossRefGoogle Scholar
  2. Kroft, S. H. (2012). Bone marrow. In S. E. Mills (Ed.), Histology for pathologists (4th ed., pp. 849–887). Philadelphia: Lippincot Williams and Wilkins.Google Scholar
  3. Swerdlow, S. H., Campo, E., Harris, N. L., Jaffe, E. S., Pileri, S. A., Stein, H., & Thiele, J. (2017). WHO classification of tumours of haematopoietic and lymphoid tissues (4th ed.). Lyon: International Agency for Research in Cancer.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Julie Bruneau
    • 1
    • 2
  • Chantal Brouzes
    • 1
    • 2
  • Vahid Asnafi
    • 1
    • 2
  • Thierry Jo Molina
    • 1
    • 2
    Email author
  1. 1.Department of PathologyHôpital Universitaire Necker-Enfants Malades, AP-HP, Université Paris Descartes, Université de ParisParisFrance
  2. 2.Laboratory of Onco-HematologyHôpital Universitaire Necker-Enfants Malades, AP-HP, Université Paris Descartes, Université de ParisParisFrance