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Optimal Design of Offset-Specific Radio Frequency Pulses for Solution and Solid-State NMR Using a Genetic Algorithm

  • Manu Veliparambil Subrahmanian
  • Aurelio James Dregni
  • Gianluigi Veglia
Reference work entry

Abstract

In this chapter, we describe the necessary steps to optimize the design of radiofrequency pulses for solution and solid-state NMR spectroscopy using a genetic algorithm (GA). We show that GA-optimized pulses significantly improve both sensitivity and resolution of NMR experiments, eliminating experimental imperfections. Additionally, we demonstrate the use of GA optimization to design band-selective pulses and manipulate individual spin systems with significantly different chemical shifts such as carbonyl and aliphatic carbon nuclei. These new offset-specific pulses (OSP) are of general use and can perform various operations on nuclei based on their chemical shift offsets. Replacing multiple band selective pulses with a single OSP can dramatically reduce pulsing time and power in classical NMR pulse sequences, increasing the sensitivity in multidimensional experiments.

Keywords

Genetic algorithm optimization NMR pulse design Composite pulses RF inhomogeneity Broad-band pulses 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Manu Veliparambil Subrahmanian
    • 1
  • Aurelio James Dregni
    • 1
  • Gianluigi Veglia
    • 1
    • 2
  1. 1.Department of Biochemistry, Molecular Biology and BiophysicsUniversity of MinnesotaMinneapolisUSA
  2. 2.Department of ChemistryUniversity of MinnesotaMinneapolisUSA

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