Synonyms
Ameloblastoma with extensive stromal desmoplasia; Ameloblastoma with pronounced desmoplasia; Desmoplastic and osteoplastic ameloblastoma; Desmoplastic variant of ameloblastoma
Definition
The desmoplastic ameloblastoma is an unusual variant of intraosseous ameloblastoma. It is characterized by extensive stromal collagenization. This variant differs from conventional solid and multicystic ameloblastoma in not only its histopathologic features but also its clinical and radiographic presentation.
Clinical Features
Incidence
The incidence is unknown. Desmoplastic ameloblastoma comprises approximately 4–13 % of all ameloblastomas. Some studies suggest the relative frequency may be slightly lower in Japan compared to America and Europe (Philipsen et al. 2001).
Age
The average age at diagnosis is 43 years, with a range of 17–72 years. Among females, there is a peak in the fourth and fifth decades, whereas among males, there is a peak in the sixth decade (Philipsen et al. 2001).
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References and Further Reading
Bologna-Molina, R., Mosqueda-Taylor, A., Lopez-Corella, E., de Almeida, O. P., Carrasco-Daza, D., Farfan-Morales, J. E., et al. (2009). Comparative expression of syndecan-1 and Ki-67 in peripheral and desmoplastic ameloblastomas and ameloblastic carcinoma. Pathology International, 59(4), 229–233.
Kumamoto, H., Ohki, K., & Ooya, K. (2005). Expression of p63 and p73 in ameloblastomas. Journal of Oral Pathology & Medicine, 34(4), 220–226.
Philipsen, H. P., Reichart, P. A., & Takata, T. (2001). Desmoplastic ameloblastoma (including “hybrid” lesion of ameloblastoma). Biological profile based on 100 cases from the literature and own files. Oral Oncology, 37(5), 455–460.
Siar, C. H., & Ng, K. H. (1993). Patterns of expression of intermediate filaments and S-100 protein in desmoplastic ameloblastoma. The Journal of Nihon University School of Dentistry, 35(2), 104–108.
Takata, T., Miyauchi, M., Ogawa, I., Kudo, Y., Takekoshi, T., Zhao, M., et al. (2000). Immunoexpression of transforming growth factor beta in desmoplastic ameloblastoma. Virchows Archiv, 436(4), 319–323.
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Chi, A. (2016). Ameloblastoma, Desmoplastic. In: Slootweg, P.J. (eds) Dental and Oral Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28085-1_654
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DOI: https://doi.org/10.1007/978-3-319-28085-1_654
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