Advertisement

Immunotactoid Glomerulopathy

Living reference work entry

Abstract

Immunotactoid glomerulopathy (ITG) describes a glomerular lesion with specific ultrastructural features of organized deposits, most often microtubular and/or in parallel arrays, usually with monotypic immunoglobulin staining. It is diagnosed in the absence of cryoglobulinemia and is often associated with underlying lymphoproliferative disease, which results in production of the pathogenic paraprotein with subsequent renal deposition. Treatment of such underlying diseases has shown beneficial results in some patients.

Keywords

Immunotactoid glomerulopathy Fibrillary glomerulonephritis Organized deposits Microtubular Cryoglobulinemia Lymphoproliferative disease Mesangioproliferative Membranoproliferative Atypical membranous Paraprotein 

References

  1. Alpers CE (1992) Immunotactoid (microtubular) glomerulopathy: an entity distinct from fibrillary glomerulonephritis? Am J Kidney Dis 19:185–191CrossRefPubMedGoogle Scholar
  2. Alpers CE (1993) Fibrillary glomerulonephritis and immunotactoid glomerulopathy: two entities, not one. Am J Kidney Dis 22:448–451CrossRefPubMedGoogle Scholar
  3. Bridoux F, Hugue V, Coldefy O, Goujon JM, Bauwens M, Sechet A, Preud’Homme JL, Touchard G (2002) Fibrillary glomerulonephritis and immunotactoid (microtubular) glomerulopathy are associated with distinct immunologic features. Kidney Int 62:1764–1775CrossRefPubMedGoogle Scholar
  4. Carles X, Rostaing L, Modesto A, Orfila C, Cisterne JM, Delisle MB, Durand D (2000) Successful treatment of recurrence of immunotactoid glomerulopathy in a kidney allograft recipient. Nephrol Dial Transplant 15:897–900CrossRefPubMedGoogle Scholar
  5. Fogo A, Quereshi N, Horn RG (1993) Morphological and clinical features of fibrillary glomerulonephritis versus immunotactoid glomerulopathy. Am J Kidney Dis 22:367–377CrossRefPubMedGoogle Scholar
  6. Iskandar SS, Falk RJ, Jennette JC (1992) Clinical and pathologic features of fibrillary glomerulonephritis. Kidney Int 42:1401–1407CrossRefPubMedGoogle Scholar
  7. Korbet SM, Schwartz MM, Lewis EJ (1991) Immunotactoid glomerulopathy. Am J Kidney Dis 17:247-257Google Scholar
  8. Mallett A, Tang W, Hart G, McDonald SP, Hawley CM, Badve SV, Boudville N, Brown FG, Campbell SB, Clayton PA, Johnson DW (2015) End-stage kidney disease due to fibrillary glomerulonephritis and immunotactoid glomerulopathy – outcomes in 66 consecutive ANZDATA registry cases. Am J Nephrol 42:177–184CrossRefPubMedGoogle Scholar
  9. Nasr SH, Fidler ME, Cornell LD, Leung N, Cosio FG, Sheikh SS, Amir AA, Vrana JA, Theis JD, Dogan A, Sethi S (2012) Immunotactoid glomerulopathy: clinicopathologic and proteomic study. Nephrol Dial Transplant 27:4137–4146CrossRefPubMedGoogle Scholar
  10. Pronovost PH, Brady HR, Gunning ME, Espinoza O, Rennke HG (1996) Clinical features, predictors of disease progression and results of renal transplantation in fibrillary immunotactoid glomerulopathy. Nephrol Dial Transplant 11:837–842CrossRefPubMedGoogle Scholar
  11. Rosenstock JL, Markowitz GS, Valeri AM, Sacchi G, Appel GB, D’Agati VD (2003) Fibrillary and immunotactoid glomerulonephritis: distinct entities with different clinical and pathologic features. Kidney Int 63:1450–1461CrossRefPubMedGoogle Scholar
  12. Sathyan S, Khan FN, Ranga KV (2009) A case of recurrent immunotactoid glomerulopathy in an allograft treated with Rituximab. Transplant Proc 41:3953–3955CrossRefPubMedGoogle Scholar
  13. Schwartz MM, Korbet SM, Lewis EJ (2002) Immunotactoid glomerulopathy. J Am Soc Nephrol 13:1390–1397CrossRefPubMedGoogle Scholar
  14. Sethi S, Theis JD, Vrana JA, Fervenza FC, Sethi A, Qian Q, Quint P, Leung N, Dogan A, Nasr SH (2013) Laser microdissection and proteomic analysis of amyloidosis, cryoglobulinemic GN, fibrillary GN, and immunotactoid glomerulopathy. Clin J Am Soc Nephrol 8:915–921CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Pathology, Microbiology and ImmunologyVanderbilt University Medical CenterNashvilleUSA

Personalised recommendations