Fibrillary glomerulonephritis is a progressive glomerulopathy characterized by the deposition of abnormal fibrils having an ultrastructural appearance similar to amyloid fibrils that are likely composed of abnormal immunoglobulins. It is a morphologically defined entity that is somewhat clinically heterogeneous. The precise etiology for this process is unknown. A kidney biopsy and, in particular electron microscopy, is required for establishing the diagnosis. There is a strong propensity to end-stage renal disease. Randomized controlled clinical trials of therapies for this disease remain to be reported.
KeywordsFibrillary glomerulonephritis Fibrils Mesangium Basement membranes Electron microscopy
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