IgA Nephropathy - Clinical Features, Pathogenesis, and Treatment

  • Gerald B. Appel
Living reference work entry


IgA Nephropathy is recogniszed as the most frequent form of glomerulonephritis worldwide. The disease is defined by the presence of IgA immune deposits in the glomereuli. Although the presentation is variable, the course is often one of insidous progression to end stage kidney disease with 15-20 % of patients reaching this point by 10 yrs and more with furhter follow. Recent studies have helped define which patients are high risk for progression using clinical and histopathologic features defined by a uniform pathology scoring system. Although much has recently been discovered about the pathogenesis of IgAN treatment studies have given conflicting results.


IgA nephropathy Glomerular disease Henoch schoelein purpura Glomerulonephritis 


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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of MedicineColumbia University College of Physicians and SurgeonsNew YorkUSA

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