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Carcinomas with a Squamous Cell Lineage

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Book cover Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Abstract

Several types of bile duct cancer are characterized by a squamous cell lineage. Squamous cell carcinomas with keratinization can occur in both extrahepatic and intrahepatic bile ducts. These tumors may present as lesions entirely composed of cancerous keratinocytes or occur in conjunction with other cellular components, such as adenocarcinoma. Overall, these are rare neoplasms that account for less than 2 % of biliary malignancies. Most of squamous cell carcinomas originate from bile ducts, but the site of origin may be difficult to determine in intrahepatic tumors. There is evidence that squamous cell carcinoma can develop in the liver substance without detectable association with bile ducts. These neoplasms can also develop in various types of hepatic cysts, in particular choledochal cysts. Adenosquamous carcinoma is a rare malignancy containing both squamous and glandular elements. In the liver, it develops either as a variant of cholangiocarcinoma or as a neoplasm not proven to be related to bile ducts. A further and very uncommon hepatobiliary carcinoma that possesses a squamous cell lineage is mucoepidermoid carcinoma.

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Zimmermann, A. (2017). Carcinomas with a Squamous Cell Lineage. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_42

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  • DOI: https://doi.org/10.1007/978-3-319-26956-6_42

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-26954-2

  • Online ISBN: 978-3-319-26956-6

  • eBook Packages: MedicineReference Module Medicine

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