Abstract
Intrahepatic cholangiocarcinoma (ICC) is a cholangiocellular malignancy arising in any portion of the intrahepatic biliary tract. ICC can develop from small bile ducts and then occupies a peripheral compartment of the liver, but it also occurs in perihilar intrahepatic ducts and has to be distinguished from perihilar/hilar carcinoma of extrahepatic ducts. Overall, ICC is a rare neoplasm that accounts for less than 2 % of all malignant solid tumors. In relation to bile ducts involved, ICC is classified as a bile duct type (conventional type), further subdivided into a small bile duct type (peripheral type) and a large bile duct type (perihilar type), and a bile ductular type (bile ductular carcinoma or cholangiolocellular carcinoma). Several systems of pathomorphological classification of ICC have been proposed. The most commonly used system of the Japanese Liver Cancer Study Group distinguished mass-forming ICC, periductal-infiltrating ICC, and intraductal growth ICC. In the setting of the novel category of intraductal papillary neoplasm of the bile duct (IPN-B), treated in a separate chapter, most cases of intraductal growth ICC can now be considered to be invasive forms of IPN-B.
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Zimmermann, A. (2017). Intrahepatic Cholangiocarcinomas (ICCs). In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_29
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