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Suction Blisters and Microdialysis

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Agache’s Measuring the Skin

Abstract

The extracellular space represents the junction point of nutriments, mediators, hormones, drugs and metabolites as well as toxins with target cutaneous cells. Few techniques allow nowadays the study of these compartments in vivo, in the dermis. Scientists usually study plasmatic pharmacokinetics to solve the problems with drug dermal kinetics. However two techniques allow to perform pharmacokinetics or metabolism studies, by studying extracellular fluids endogenous or exogenous substances concentrations:

  1. 1.

    A relatively old technique, suction blisters (Kiistala 1967)

  2. 2.

    A more recent technique, at least for its cutaneous applications, microdialysis (Anderson et al. 1991)

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Author information

Authors and Affiliations

  1. Skinexigence, Besançon, France

    Sophie Mac-Mary

  2. Engineering and Cutaneous Biology Laboratory, University of Franche-Comte, Besançon, France

    Patrice Muret

Authors
  1. Sophie Mac-Mary
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  2. Patrice Muret
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Correspondence to Sophie Mac-Mary .

Editor information

Editors and Affiliations

  1. Medecine Vasculaire Lab. Ingénierie et de Biologie Cutanées, CHU Besancon Service Dermatologie et, Besancon, France

    Philippe Humbert

  2. San Francisco, California, USA

    Howard Maibach

  3. Department of Dermatology, Saint Jacques University Hospital, Besançon, France

    Ferial Fanian

  4. Univ. Besançon Dépt. Dermatologie, Besançon, France

    Pierre Agache

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Mac-Mary, S., Muret, P. (2015). Suction Blisters and Microdialysis. In: Humbert, P., Maibach, H., Fanian, F., Agache, P. (eds) Agache’s Measuring the Skin. Springer, Cham. https://doi.org/10.1007/978-3-319-26594-0_143-1

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  • DOI: https://doi.org/10.1007/978-3-319-26594-0_143-1

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  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-26594-0

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