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Agache’s Measuring the Skin pp 1–8Cite as

Microbiology of Skin Surface

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Abstract

The human skin is the largest organ of the human body. Skin flora is a vital component of human biology and it has greater implications in skin health and some skin disease. In a healthy individual, bacterial flora serves to protect the host. On the other hand, when the skin barrier function is damaged or broken, the risk of developing skin infections is increased obviously. This review serves to highlight the current progress research in skin microbial composition and distribution of the skin flora have been associated with many skin disease, such as atopic dermatitis, acne vulgaris and psoriasis.

Keywords

  • 16S rRNA
  • Acne vulgaris (AV)
  • Atopic dermatitis (AD)
  • Psoriasis vulgaris (PV)
  • Skin flora
  • Skin microbiome
  • Vulvar skin

X. Wang: deceased.

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References

  • Allen HB, Jones NP, Bowen SE. Lichenoid and other clinical presentations of atopic dermatitis in an inner city practice. J Am Acad Dermatol. 2008;58:503–4.

    CrossRef  PubMed  Google Scholar 

  • Al-saimary IE, Bakr SS, Al-Hamdi KE. Staphylococcus aureus as a causative agent of atopic dermatitis/eczema syndrome (ADES) and its therapeutic implications. Internet J Dermatol. 2005;3(2):1.

    Google Scholar 

  • Aly R, Britz MB, Maibach HI. Quantitative microbiology of human vulva. Br J Dermatol. 1979;101:445–8.

    CrossRef  CAS  PubMed  Google Scholar 

  • Arun C, Palit IA. The genus Malassezia and human disease. Indian J Dermatol Venereol Leprol. 2003;69:265–70.

    Google Scholar 

  • Baker BS. The role of microorganisms in atopic dermatitis. Clin Exp Immunol. 2006;144:1–9.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Brown CJ, Wong M, Davis CC, et al. Preliminary characterization of the normal microbiota of the human vulva using cultivation-independent methods. J Med Microbiol. 2007;56:271–6.

    CrossRef  CAS  PubMed  Google Scholar 

  • Bruggemann H, Henne A, Hoster F, et al. The complete genome sequence of Propionibacterium acnes, a commensal of human skin. Science. 2004;305:671–3.

    CrossRef  PubMed  Google Scholar 

  • Callewaert C, Kerckhof FM, Granitsiotis MS, et al. Characterization of Staphylococcus and corynebacterium clusters in the human axillary region. PLoS One. 2013;8, e70538.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Cunliffe WJ. Looking back to the future – acne. Dermatology. 2002;204:167–72.

    CrossRef  CAS  PubMed  Google Scholar 

  • Dunbar J, Barns SM, Ticknor LO, et al. Empirical and theoretical bacterial diversity in four Arizona soils. Appl Environ Microbiol. 2002;68:3035–45.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Fierer N, Hamady M, Lauber CL, et al. The influence of sex, handedness, and washing on the diversity of hand surface bacteria. Proc Natl Acad Sci U S A. 2008;105:17994–9.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Gao Z, Tseng CH, Pei Z, et al. Molecular analysis of human forearm superficial skin bacterial biota. Proc Natl Acad Sci U S A. 2007;104:2927–32.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Gao Z, Tseng CH, Strober BE, et al. Substantial alterations of the cutaneous bacterial biota in psoriatic lesions. PLoS One. 2008;3, e2719.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Gomes PLR, Malavige GN, Fernando N, et al. Characteristics of Staphylococcus aureus colonization in patients with atopic dermatitis in Sri Lanka. Clin Exp Dermatol. 2011;36(2):195–200.

    CrossRef  CAS  PubMed  Google Scholar 

  • Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011;4:245–53.

    Google Scholar 

  • Grice EA, Kong HH, Renaud G, et al. A diversity profile of the human skin microbiota. Genome Res. 2008;18:1043–50.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Guzik TJ, Bzowska M, Kasprowicz A, et al. Persistent skin colonization with Staphylococcus aureus in atopic dermatitis: relationship to clinical and immunological parameters. Clin Exp Allergy. 2005;35(4):448–55.

    CrossRef  CAS  PubMed  Google Scholar 

  • Haslund P, Bangsgaard N, Jarlov J, et al. Staphylococcus aureus and hand eczema severity. Br J Dermatol. 2009;161(4):772–7.

    CrossRef  CAS  PubMed  Google Scholar 

  • Higaki S, Kitagawa T, Kagoura M, et al. Correlation between Propionibacterium acnes biotypes, lipase activity and rash degree in acne patients. J Dermatol. 2000;27:519–22.

    CrossRef  CAS  PubMed  Google Scholar 

  • Hill SE, Yung A, Rademaker M. Prevalence of Staphylococcus aureus and antibiotic resistance in children with atopic dermatitis: a New Zealand experience. Australas J Dermatol. 2011;52:27–31.

    CrossRef  PubMed  Google Scholar 

  • Hon KL, Lam MC, Leung TF, et al. Clinical features associated with nasal Staphylococcus aureus colonisation in Chinese children with moderate-to-severe atopic dermatitis. Ann Acad Med Singapore. 2005;34(10):602–5.

    CAS  PubMed  Google Scholar 

  • Isolauri E, Turjanmaa K. Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis. J Allergy Clin Immunol. 1996;97:9–15.

    CrossRef  CAS  PubMed  Google Scholar 

  • Lindner MT, Johansson C, Scheynius A, et al. Positive atopic patch test reactions to Pityrosporum orbiculare in atopic dermatitis patients. Clin Exp Allergy. 2000;30:122–31.

    CrossRef  Google Scholar 

  • Matsui K, Gilani SJ, Gonzalez M, et al. Staphylococcus aureus re-colonization in atopic dermatitis: beyond the skin. Clin Exp Dermatol. 2005;30(1):10–3.

    CrossRef  Google Scholar 

  • Mikamo H, Kawazoe K, Sato Y, et al. Preterm labor and bacterial intra-amniotic infection: arachidonic acid liberation by phospholipase A2 of Prevotella bivia. Anaerobe. 1998;4:209–12.

    CrossRef  CAS  PubMed  Google Scholar 

  • Miyamoto T, Akiba S, Sato N, et al. Study of the vulvar skin in healthy Japanese women: components of the stratum corneum and microbes. Int J Dermatol. 2013;52:1500–5.

    CrossRef  PubMed  Google Scholar 

  • Mowad CM, McGinley KJ, Foglia A, et al. The role of extracellular polysaccharide substance produced by Staphylococcus epidermidis in miliaria. J Am Acad Dermatol. 1995;33:729–33.

    CrossRef  CAS  PubMed  Google Scholar 

  • Myhre AK, Bevanger LS, Berntzen K, et al. Anogenital bacteriology in non-abused preschool children: a descriptive study of the aerobic genital flora and the isolation of anogenital Gardnerella vaginalis. ACTA Paediatr. 2002;91:885–91.

    CrossRef  CAS  PubMed  Google Scholar 

  • Pezesk PFZ, Miri S, Ghasemi R, et al. Skin colonization with Staphylococcus aureus in patients with atopic dermatitis. Internet J Dermatol. 2007;5 (1). doi:10.5580/e93.

    Google Scholar 

  • Rippke F, Schreiner V, Schwanitz HJ. The acidic milieu of the horny layer: new findings on the physiology and pathophysiology of skin pH. Am J Clin Dermatol. 2002;3:261–72.

    CrossRef  PubMed  Google Scholar 

  • Ro BI, Dawson TL. The role of sebaceous gland activity and scalp microfloral metabolism in the etiology of seborrheic dermatitis and dandruff. J Invest Dermatol Symp Proc. 2005;10:94–197.

    CrossRef  Google Scholar 

  • Roth RR, James WD. Microbial ecology of the skin. Annu Rev Microbiol. 1988;42:441–64.

    CrossRef  CAS  PubMed  Google Scholar 

  • Salah SB, Makni F, Marrakchi S, et al. Identification of Malassezia species from Tunisian patients with pityriasis versicolor and normal subjects. Mycoses. 2005;48:242–5.

    CrossRef  PubMed  Google Scholar 

  • Serra E, Puig S, Otero D, et al. Confirmation of a double-hit model for the NF1 gene in benign neurofibromas. Am J Hum Genet. 1997;61:512–9.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Shiraishi T, Fukuda K, Morotomi N, et al. Influence of menstruation on the microbiota of healthy women’s labia minora as analyzed using a 16S rRNA gene-based clone library method. Jpn J Infect Dis. 2011;64:76–80.

    PubMed  Google Scholar 

  • Takahata Y, Sugita T, Kato H, et al. Cutaneous Malassezia flora in atopic dermatitis differs between adults and children. Br J Dermatol. 2007;157:1178–82.

    CrossRef  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Shanghai, China

    Xuemin Wang

  2. Department of Skin and Cosmetic Research, Shanghai Skin Disease Hospital, 200443, Shanghai, China

    Chao Yuan

  3. Research and Studies Center on the Integument (CERT), Department of Dermatology, Besançon University Hospital, University of Franche-Comté, Besançon, France

    Philippe Humbert

Authors
  1. Xuemin Wang
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  2. Chao Yuan
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  3. Philippe Humbert
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Corresponding author

Correspondence to Chao Yuan .

Editor information

Editors and Affiliations

  1. Medecine Vasculaire Lab. Ingénierie et de Biologie Cutanées, CHU Besancon Service Dermatologie et, Besancon, France

    Philippe Humbert

  2. San Francisco, California, USA

    Howard Maibach

  3. Department of Dermatology, Saint Jacques University Hospital, Besançon, France

    Ferial Fanian

  4. Univ. Besançon Dépt. Dermatologie, Besançon, France

    Pierre Agache

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© 2015 Springer International Publishing Switzerland

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Wang, X., Yuan, C., Humbert, P. (2015). Microbiology of Skin Surface. In: Humbert, P., Maibach, H., Fanian, F., Agache, P. (eds) Agache’s Measuring the Skin. Springer, Cham. https://doi.org/10.1007/978-3-319-26594-0_10-1

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  • DOI: https://doi.org/10.1007/978-3-319-26594-0_10-1

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  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-26594-0

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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