Brazzein: A Natural Sweetenerz

  • V. Rajan
  • J. A. Howard
Living reference work entry

Later version available View entry history

Part of the Reference Series in Phytochemistry book series (RSP)


Brazzein is a 54-amino acid, heat-stable sweetener derived from the ripe fruit of the West African plant Pentadiplandra brazzeana Baillon. Its historical use as a sweetener testifies to its safety, and it has been extensively studied, both in regard to its structure and interaction with taste receptors. It has also been investigated as a possible commercial product to fulfill the need for a natural, low-calorie, heat-stable sweetener. Here, we review brazzein in the context of other sweeteners and examine attempts to produce brazzein in recombinant systems.


Brazzein Sweet protein Natural sweetener Recombinant sweetener Low-calorie sweetener pyrE brazzein Type 1 brazzein Des-pyrE brazzein Type 2 brazzein E1 brazzein Type 3 brazzein T1R2/T1R3 receptors 


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Applied Biotechnology InstituteSan Luis ObispoUSA

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