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Sweet-Taste Receptor Signaling Network and Low-Calorie Sweeteners

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Sweeteners

Part of the book series: Reference Series in Phytochemistry ((RSP))

Abstract

Over the past decades, low-calorie sweeteners (LCSs) have emerged as the main source of sweetening food products and beverages. Evidences suggest mixed effects of LCSs intake. In addition, there is a paucity of data on long-term health outcomes of LCSs intake as well as their usefulness in certain groups of the population (e.g., pregnant women, children, and the elderly). Moreover, available unbiased studies conducted to date are fairly scanty, thereby restraining far-reaching conclusions. LCSs are biomolecules with cognate cellular receptors ubiquitously localized in many organs and tissues of the body. The T1R2-T1R3 receptor heterodimer is one of the widely known receptors of LCSs. Upon activation by LCSs, T1R2-T1R3 signals downstream that result in several cellular responses that characterize the biochemical and physiological effects of LCSs. In the gut, for instance, signaling of LCSs may be mediated via humoral and neural mechanisms (involving the gut-brain axis, gut-adipose tissue axis, gut-adipose tissue-brain triangle, gut-pancreas-adipose tissue or entero-adipo-insular triangle, gut-brain-adipose tissue triangle) influence obesity, overweight, appetite, satiety, cognition, and memory. Several interconnected signaling pathways are important in modulating the physiological outcomes of LCS intake. In this chapter, we discuss the signaling mechanisms of LCSs, and their relationship to metabolism, obesity, weight gain, satiety, appetite, cognition, and memory.

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Abbreviations

AC:

Adenylate cyclase

ACTH:

Adrenocorticotropic Hormone

AgRP:

Agouti-related protein

AMPK:

AMP-activated protein kinase

AP:

Area postrema

ATP:

Adenosine triphosphate

CALHM1:

Calcium homeostasis modulator 1

CAMK:

Calmodulin-dependent protein kinase

cAMP:

Cyclic adenosine monophosphate

CART:

Cocaine and amphetamine regulated transcript

CREB:

cAMP-related element binding protein

CRH:

Corticotropin releasing hormone

DMN:

Dorsomotor nucleus

GABA:

Gamma amino butyric acid

GLP-1:

Glucagon-like peptide-1

GLUT:

GLUcose Transporter

IP3:

1,4,5-inositol trisphosphate

Low-calorie sweeteners:

LCSs

MC4R:

Melanocortin receptor type-4

mTOR:

Mammalian target of rapamycin

mTORC1:

Mammalian target of rapamycin 1

NPY:

Neuropeptide Y

NTS:

Nucleus tractus solitarius

Ob-Rb:

Adiposity (obesity) receptor type b

PDE:

Phosphodiesterase

PI3K:

Phosphoinositide-3-kinase

PKB:

Protein kinase B

PLCβ:

Phospholipase Cβ

POMC:

Proopiomelanocortin

PVN:

Paraventricular nucleus

PYY:

Peptide YY

SGLT:

Sodium-dependent glucose cotransporter

T1R2-T1R3:

Sweet-taste receptor heterodimer

TRH:

Thyrotropin releasing hormone

TRPM5:

Transient receptor potential cation channel, subfamily M, member 5

α-MSH:

Alpha-melanin-stimulating hormone

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Author information

Authors and Affiliations

  1. Department of Physiology, Faculty of Basic Medical Sciences, Madonna University, Elele, Rivers State, Nigeria

    Menizibeya O. Welcome

  2. World Scientific and Engineering Society and Academy, Athens, Greece

    Menizibeya O. Welcome & Nikos E. Mastorakis

  3. Technical University of Sofia, Sofia, Bulgaria

    Nikos E. Mastorakis

  4. Department of Normal Physiology, Belarusian State Medical University, Pr., Dzerjinsky, 83, 220116, Minsk, Belarus

    Vladimir A. Pereverzev

Authors
  1. Menizibeya O. Welcome
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  2. Nikos E. Mastorakis
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  3. Vladimir A. Pereverzev
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Corresponding author

Correspondence to Menizibeya O. Welcome .

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Editors and Affiliations

  1. Ins. des Sciences de la Vigne et du, Université de Bordeaux, Villenave d'Ornon, Gironde, France

    Jean-Michel Merillon

  2. Botany Department, M.L.Sukhadia University, Udaipur, Rajasthan, India

    Kishan Gopal Ramawat

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Welcome, M.O., Mastorakis, N.E., Pereverzev, V.A. (2016). Sweet-Taste Receptor Signaling Network and Low-Calorie Sweeteners. In: Merillon, JM., Ramawat, K. (eds) Sweeteners. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-26478-3_25-1

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  • DOI: https://doi.org/10.1007/978-3-319-26478-3_25-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-26478-3

  • Online ISBN: 978-3-319-26478-3

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