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Glucosinolates pp 301-317 | Cite as

Antileukemic Activity of Sulforaphane

  • Elena CatanzaroEmail author
  • Carmela Fimognari
Reference work entry
Part of the Reference Series in Phytochemistry book series (RSP)

Abstract

The biological complexity of cancer offers numerous targets for antineoplastic therapies. Diet is a common source of biologically active compounds. Many studies demonstrated an inverse relation between the consumption of vegetables and the risk of cancer. In this context, the interest is currently focused toward the study of certain diet-derived molecules to prevent, delay, or treat cancer by acting simultaneously on different critical pathways. Among phytochemicals, sulforaphane, an isothiocyanate derived from the hydrolysis of the glucosinolate glucoraphanin mainly present in Brassica vegetables, is one of the most promising diet-derived molecules. In this chapter, we will present the antileukemic activity of sulforaphane and discuss its therapeutic potential in terms of mechanisms of action, safety, and limits.

Keywords

Leukemia Sulforaphane Brassica vegetables Dietary phytochemicals Apoptosis Cell cycle 

Abbreviations

AKT

Plasmatic protein kinase B

ALL

Acute lymphoblastic leukemia

AML

Acute myeloid leukemia

APL

Acute promyelocytic leukemia

B-ALL

Acute B-lymphoblastic leukemia

CDK

Cyclin-dependent kinase

CLL

Chronic lymphoblastic leukemia

CML

Chronic myeloid leukemia

CYC

Cyclin

CYP450

Cytochrome P450

DSB

Double-strand break

GCLC

Glutamate-cysteine ligase catalytic

GCLM

Glutamate-cysteine ligase modifier

GLS

Glucosinolate

GSH

Glutathione

HRR

Homologous recombination repair

ITC

Isothiocyanate

mTOR

Mammalian target of rapamycin

PARP

Poly (ADP-ribose) polymerase

PIP3

Phosphatidylinositol 3-kinase

QR NAD(P)H

Oxidoreductase

ROS

Reactive oxygen species

SFN

Sulforaphane

STAT

Signal transducers and activators of transcription

T-ALL

Acute T-lymphoblastic leukemia

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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Department for Life Quality StudiesAlma Mater Studiorum-University of BolognaRiminiItaly

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