Advertisement

Photodynamic Therapy for Photodamaged Skin

  • Ana Carolina Junqueira Ferolla
  • Maria Claudia Almeida Issa
Living reference work entry
Part of the Clinical Approaches and Procedures in Cosmetic Dermatology book series (CAPCD)

Abstract

Photodynamic therapy (PDT) is a well-established therapeutic modality for nonmelanoma skin cancer (NMSC). It is based on a photochemical reaction, which causes destruction of the target tissue associated with an inflammatory response. In the last years, PDT has been indicated for some dermatosis in cosmetic dermatology, such as acne, sebaceous hyperplasia, rosacea, and photoaging. Although PDT’s mechanism of action in these dermatoses is not totally clear, some histological studies had shown dermis remodeling induced by PDT in photodamaged skin. In this chapter, we are going to discuss about photoaging and PDT treatment, comparing literature review and authors’ experience.

Keywords

Photodynamic therapy Photosensitizer Nonmelanoma skin cancer Actinic keratosis Basal cell carcinoma Bowen disease Photodamaged skin Collagen fibers Elastic fibers Skin remodeling Dermis Aging Photoaging Photorejuvenation Rejuvenation 

References

  1. Alexiades-Armenakias MR, Gernemus RG. Laser-mediated photodynamic therapy of actinic keratosis. Arch Dermatol. 2003;139:1313–20.CrossRefGoogle Scholar
  2. Almeida Issa MC, Piñeiro-Maceira J, Farias, et al. Immunohistochemical expression of matrix metalloproteinases in photodamaged skin by photodynamic therapy. Br J Dermatol. 2009;161(3):647–53.CrossRefPubMedGoogle Scholar
  3. Alster TS, Tanzi EL. Photodynamic therapy with topical aminolevulinic acid and pulsed dye laser irradiation for sebaceous hyperplasia. J Drugs Dermatol. 2003;2:501–4.PubMedGoogle Scholar
  4. Alster TS, Tanzi EL, Welsh EC. Photorejuvenation of facial skin with topical 20% 5-aminolevulinic acid and intense pulsed light treatment: a split-face comparison study. J Drugs Dermatol. 2005;4:35–8.PubMedGoogle Scholar
  5. Babilas P, Karrer S, Sidoroff A, et al. Photodynamic therapy in dermatology: an update. Photodermatol Photoimmunol Photomed. 2005;21:142–9.CrossRefPubMedGoogle Scholar
  6. Bissonnette R, Tremblay J-F, Juzenas P, Boushira M, Lui H. Systemic photodynamic therapy with aminolevulinic acid induces apoptosis in lesional T lymphocytes of psoriatic plaques. J Invest Dermatol. 2002;119:77–83.CrossRefPubMedGoogle Scholar
  7. Bjerring P, Clement M, Heickendorff L, Lybecker H, Kiernan M. Dermal collagen production following irradiation by dye laser and broadband light source. J Cosmet Laser Ther. 2002;4:39–43.CrossRefPubMedGoogle Scholar
  8. Bjerring P, Christiansen K, Troilius A, et al. Skin fluorescence controlled photodynamic photorejuvenation. J Lasers Surg Med. 2009;41(5):327–36.CrossRefPubMedGoogle Scholar
  9. Brenneisen P, Sies H, Scharffetter-Kochanek K. Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events. Ann N Y Acad Sci. 2002;973:31–43.CrossRefPubMedGoogle Scholar
  10. Bruscino N, Rossi R, Dindelli M, et al. Facial skin rejuvenation in a patient treated with photodynamic therapy for actinic keratosis. Dermatol Ther. 2010;23(1):86–9.CrossRefPubMedGoogle Scholar
  11. Calvazara-Pinton P, Arisi M, Sereni E, Ortel B. A critical reappraisal of off-label indications for topical photodynamic therapy with aminolevulinic acid and methylaminolevulinate. Rev Recent Clin Trilas. 2010;5(2):112–6.CrossRefGoogle Scholar
  12. Casas A, Fukuda H, Di Venosa G, et al. Photosensitization and mechanism of cytotoxicity induced by the use of ALA derivatives in photodynamic therapy. Br J Cancer. 2001;85:279–84.CrossRefPubMedPubMedCentralGoogle Scholar
  13. Chung JH, Seo JY, Choi HR, Lee MK, Youn CS, Rhie G, et al. Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Invest Dermatol. 2001;117(5):1218–24.CrossRefPubMedGoogle Scholar
  14. Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D, Korbelik M, et al. Photodynamic therapy. J Natl Cancer Inst. 1998;90(12):889–905.CrossRefPubMedPubMedCentralGoogle Scholar
  15. Dover JS, Bhatia AC, Stewart B, Arndt KA. Topical 5-aminolevulinic acid combined with intense pulsed light in the treatment of photoaging. Arch Dermatol. 2005;141:1247–52.CrossRefPubMedGoogle Scholar
  16. Ferolla ACJ. Estudo da pele humana fotoenvelhecida após tratamento com terapia fotodinâmica associada ao ácido 5 delta aminolevulínico tópico: avaliação imunoistoquímica, do colágeno e do tecido elastic [TESE]. São Paulo: Faculdade de Medicina da Universidade de São Paulo; 2007.Google Scholar
  17. Fink-Puches R, Soyer HA, Hofer A, et al. Long-term follow-up and histological changes of superficial nonmelanoma skin cancers treated with topical δ-aminolevulinic acid photodynamic therapy. Arch Dermatol. 1998;134:821–6.CrossRefPubMedGoogle Scholar
  18. Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002;138(11):1462–70.CrossRefPubMedGoogle Scholar
  19. Gilchrest BA. Skin aging and photoaging: an overview. J Am Acad Dermatol. 1989;21:610–3.CrossRefPubMedGoogle Scholar
  20. Gold MH, Goldman MP. 5-aminolevulinic acid photodynamic therapy: where we have been and where we are going. Dermatol Surg. 2004;30:1077–84.PubMedGoogle Scholar
  21. Gold MH, Bradshow VL, Boring MM, Bridges TM, Biron JA. Split face comparison of photodynamic therapy with 5-aminolevulinic acid and intense pulsed light versus intense pulsed light versus intense pulsed light alone for photodamage. Dermatol Surg. 2006;32:795–801.PubMedGoogle Scholar
  22. Hurlimann AF, Panavizzon RG, Burg A. Topical photodynamic treatment of skin tumours and dermatoses. Dermatology. 1994;3:327.Google Scholar
  23. Issa MCA. Estudo Da Remodelação Dérmica Induzida Pela Terapia Fotodinâmica (MAL-TFD) Na Pele Fotodanificada [Tese]. Rio de Janeiro: Universidade Federal do Rio de Janeiro; 2008.Google Scholar
  24. Issa MCA, Patricia-Azulay M. Terapia Fotodinâmica: revisão da literatura e documentação iconográfica. Anais Bras Dermatol. 2010;85(4):501–11.CrossRefGoogle Scholar
  25. Issa MCA, Pineiro-Maceira J, Vieira, et al. Photorejuvenation with topical methyl aminolevulinate and red light: a randomized, prospective, clinical, histopathologic, and morphometric study. Dermatol Surg. 2010;36:39–48.CrossRefPubMedGoogle Scholar
  26. Kalka K, Merk H, Mukhtar H. Photodynamic therapy in dermatology. J Am Acad Dermatol. 2000;42:389–413.CrossRefPubMedGoogle Scholar
  27. Kang S, Fisher GJ, Voorhees JJ. Photoaging: pathogenesis, prevention, and treatment. Clin Geriatr Med. 2001;17(4):643–59, v–vi.CrossRefPubMedGoogle Scholar
  28. Karrer S, Bäumler W, Abels C, Hohenleutner U, Landthaler M, Szeimies R-M. Long-pulse dye laser for photodynamic therapy: investigations in vitro and in vivo. Lasers Surg Med. 1999;25:51–9.CrossRefPubMedGoogle Scholar
  29. Karrer S, Bosserhoff AK, Weiderer P, Landthaler M, Szeimies RM. Influence of 5-aminolevulinic acid and red light on collagen metabolism of human dermal fibroblasts. J Invest Dermatol. 2003;120(2):325–31.CrossRefPubMedGoogle Scholar
  30. Kassuga LEBP, Issa MCA, Chevrand NS. Aplicação transepidérmica de medicamento associado a terapia fotodinâmica no tratamento de ceratoses actínicas. Surg Cosmet Dermatol. 2012;4(1):89–92.Google Scholar
  31. Kolh E, Torezan LA, Landthaler M, Smeizes RM. Aesthetics effects of topical photodynamic therapy. J Eur Acad Dermatol Venereol. 2010;24:1261–9.CrossRefGoogle Scholar
  32. Le Pilloer-Prost A, Cartier H. Photodynamic photorejuvenation: a review. Dermatol Surg. 2016;42(1):21–30.CrossRefGoogle Scholar
  33. Lee PK, Kloser A. Current methods for photodynamic therapy in the US: comparison of MAL/PDT and ALA/PDT. J Drugs Dermatol. 2013;12(8):925–30.PubMedGoogle Scholar
  34. Marmur ES, Phelps R, Goldberg DJ. Ultrastructural changes seen after ALA –IPL photorejuvenation: a pilot study. J Cosmet Laser Ther. 2005;7(1):21–4.CrossRefPubMedGoogle Scholar
  35. Morton CA, Szeimies RM, Sidoroff A, et al. European guidelines for topical photodynamic therapy part 2: emerging indications: field cancerization, photorejuvenation and inflammatory/infective dermatoses. J Eur Acad Dermatol Venereol. 2013;27(6):672–9.CrossRefPubMedGoogle Scholar
  36. Naderi-Hachtroudi L, Peters T, Brenneisen P, Meewes C, Hommel C, Razi-Wolf Z, et al. Induction of manganese superoxide dismutase in human dermal fibroblasts: a UV-B-mediated paracrine mechanism with the release of epidermal interleukin 1 alpha, interleukin 1 beta, and tumor necrosis factor alpha. Arch Dermatol. 2002;138(11):1473–9.CrossRefPubMedGoogle Scholar
  37. Nestor MS, Gold MH, Kauvar ANB, et al. The use of photodynamic therapy in dermatology: results of a consensus conference. J Drugs Dermatol. 2006;5:140–54.PubMedGoogle Scholar
  38. Palm MD, Goldman MP. Safety and efficacy comparison of blue versus red light sources for photodynamic therapy using methyl aminolevulinate in photodamaged skin. J Drugs Dermatol. 2011;10(1):53–60.PubMedGoogle Scholar
  39. Park MY, Sohn S, Lee ES, et al. Photorejuvenation induced by 5-aminolevulinic acid photodynamic therapy in patients with actinic keratosis: a histologic analysis. J Am Acad Dermatol. 2010;62(1):85–95.CrossRefPubMedGoogle Scholar
  40. Ruiz-Rodriguez R, Sanz-Sanchez T, Cordoba S. Photodynamic photorejuvenation. Dermatol Surg. 2002;28(8):742–4; discussion 744.PubMedGoogle Scholar
  41. Salim A, Leman JA, McColl JH, et al. Randomized comparison of photodynamic therapy with topical 5-fluorouracil in Bowen’s disease. Br J Dermatol. 2003;148:539–43.CrossRefPubMedGoogle Scholar
  42. Sanclemente G, Correa LA, Garcia JJ, et al. Methyl aminolevulinate plus red light vs. placebo plus red light in the treatment of photodamaged facial skin: histopathological findings. Exp Dermatol. 2012;37(4):379–86.CrossRefGoogle Scholar
  43. Shamban AT. Current and new treatments of photodamaged skin. Facial Plast Surg. 2009;25(5):337–46.CrossRefPubMedGoogle Scholar
  44. Szeimes RM, Torezan LA, Niwa A, et al. Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy. Br J Dermatol. 2012;16(1):150–9.CrossRefGoogle Scholar
  45. Szeimies R-M, Sassy T, Landthaler M. Penetration potency of topical applied -aminolevulinic acid for photodynamic therapy of basal cell carcinoma. Photochem Photobiol. 1994;59:73–6.CrossRefPubMedGoogle Scholar
  46. Szeimies R-M, Calzavara-Pinton PG, Karrer S, et al. Topical photodynamic therapy in dermatology. J Photochem Photobiol. 1996a;36:213–9.CrossRefGoogle Scholar
  47. Szeimies RM, Karrer S, Sauerwald A. Photodynamic therapy with topical application of 5-aminolevulinic acid in the treatment of actinic keratoses: an initial clinical study. Dermatology. 1996b;192:246–51.CrossRefPubMedGoogle Scholar
  48. Szeimies RM, Karrer S, Radakovic-Fijan S, Tanew A, Calzavara-Pinton PG, Zane C, et al. Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: a prospective, randomized study. J Am Acad Dermatol. 2002a;47:258–62.9.CrossRefPubMedGoogle Scholar
  49. Szeimies RM, Landthaler M, Karrer S. Non-oncologic indications for ALA-PDT. J Dermatolog Treat. 2002b;13 suppl 1:S13–8.CrossRefPubMedGoogle Scholar
  50. Szeimies RM, Morton CA, Sidoroff A, et al. Photodynamic therapy for non-melanoma skin cancer. Acta Derm Venereal. 2005;85:483–90.Google Scholar
  51. Togsverd-Bo K, Haak CS, Thaysen-Petersen D, et al. Intensified photodynamic therapy of actinic keratoses with fractional CO2 laser: a randomized clinical trial. Erratum Br J Dermatol. 2012;167(2):461 [corrected to Hædersdal, M].CrossRefGoogle Scholar
  52. Torezan L, Chaves Y, Niwa A, Sanches JA, Festa-Neto C, Szeimies RM. A pilot split-face study comparing conventional methylaminolevulinate-photodynamic therapy (PDT) with microneedling-assisted PDT on actinically damage skin. Dermatol Surg. 2013;39(8):1197–201.CrossRefPubMedGoogle Scholar
  53. Touma DJ, Gilchrest BA. Topical photodynamic therapy: a new tool in cosmetic dermatologic. Semin Cutan Med Surg. 2003;22:124–30.CrossRefPubMedGoogle Scholar
  54. Touma D, Yaar M, Whitehead S, Konnikov N, Gilchrest BA. A trial of short incubation, broad-area photodynamic therapy for facial actinic keratoses and diffuse photodamage. Arch Dermatol. 2004;140(1):33–40.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  • Ana Carolina Junqueira Ferolla
    • 1
  • Maria Claudia Almeida Issa
    • 2
  1. 1.Medical Ambulatory of SpecialtiesBarradasBrazil
  2. 2.Department of Clinical Medicine – DermatologyUniversidade Federal FluminenseIcarai – NiteróiBrazil

Personalised recommendations