Living Reference Work Entry

Daily Routine in Cosmetic Dermatology

Part of the series Clinical Approaches and Procedures in Cosmetic Dermatology pp 1-8

Date: Latest Version

Transepidermal Drug Delivery

  • Maria Claudia Almeida IssaAffiliated withUniversidade Federal Fluminense Email author 
  • , Gabriela CasabonaAffiliated with
  • , Paulo Santos TorreãoAffiliated withHospital dos Servidores do Estado do Rio de Janeiro
  • , Livia RoaleAffiliated withUniversidade Federal Fluminense


The stratum corneum acts as a barrier that limits the penetration of substances through the skin. Transepidermal drug delivery has been developed to increase the penetration of drugs through the superficial layers of the skin. There are many reports about ablative fractional resurfacing creating vertical channels that assist the delivery of topically applied drugs into the skin. The use of nonablative lasers as well as microneedling technique has been reported with the same purpose. In this chapter we are going to discuss some techniques, mechanism of action, and indications.


Skin drug administration Percutaneous drug administration Transdermal drug administration Transcutaneous administration Transepidermal drug delivery Transdermal drug delivery