Diabetes and Liver Disease

  • Robert HirtenEmail author
  • Henry C. BodenheimerJr.
  • David Bernstein
Reference work entry


The prevalence of diabetes is rising in the United States, with a similar increase in associated complications. Diabetes has significant deleterious effects on many organ systems including the liver. Hepatic complications include the development of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, hepatocellular carcinoma, liver failure, and the onset of diabetes following liver transplantation. There is significant morbidity and mortality associated with these conditions. Understanding the clinical characteristics and pathophysiology of diabetes related liver disease affords care providers an opportunity to prevent, monitor, and treat these complications. In order to successfully impact clinical outcomes the specific treatment of hepatic disorders must be coordinated with the management of underlying diabetes. While limited treatments currently exist, new therapeutic modalities are being developed that target insulin resistance, cytokine induced injury, and fatty acid metabolism.


Nonalcoholic fatty liver disease Cirrhosis Cryptogenic Cirrhosis Nonalcoholic steatohepatitis Hepatocellular carcinoma Hepatic steatosis Vitamin E Liver Transplantation Acute Liver Failure Hepatitis C 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Robert Hirten
    • 1
    Email author
  • Henry C. BodenheimerJr.
    • 2
  • David Bernstein
    • 1
  1. 1.Division of HepatologyNorthwell Health System, Hofstra Northwell School of MedicineManhassetUSA
  2. 2.Division of Hepatology, Hofstra Northwell School of Medicine, Northwell HealthManhassetUSA

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