Coagulation Disorders: Clinical Aspects of Platelet Disorders

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Platelets contribute to primary hemostasis, and their function is affected by their number and condition. Platelets arise from the fragmentation of megakaryocytes in the bone marrow and circulate in the blood as disk-shaped non-nucleated particles, with a life span of 7–10 days. Their average diameter is about 1.5 μm, 20% of the diameter of erythrocytes. Once released from the bone marrow, young platelets enter the circulation, where a large proportion pool in the spleen. It has been suggested that this splenic sequestration of young platelets is the result of a longer transit time of large platelets through the splenic cords. The spleen serves as a reservoir for platelets, containing about one-third, which are then able to enter the circulation after exercise or epinephrine administration. In addition to the spleen, the lungs also contain a small pool of platelets, perhaps 10–15% of the total number, and these are also able to enter the circulation after exercise or epinephrine administration (Sola and Christensen 2000).


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Women’s and Children’s Health, Neonatal Intensive Care UnitDi Venere Hospital, ASL BariBariItaly

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