Table 3 Differential diagnosis of diarrhea in the newborn and causes of intractable diarrhea (Freely adapted from Ciccarelli et al. 2013)
Metabolic or anatomic disorders | Inflammatory and immune disorders |
|---|---|
Postinfectious disaccharidase deficiency | Intolerance to cow’s milk protein |
Congenital disaccharidase defect | Intolerance to soy protein |
Cystic fibrosis | Regional enteritis |
Congenital glucose-galactose malabsorption | Ulcerative colitis |
Congenital chloridorrhea | Hirschsprung’s disease |
Congenital defect of the Na+/H+ exchanger | Intestinal lymphangiectasia |
Congenital bile acid malabsorption | Congenital microvillus atrophy |
Congenital defect of enterokinases | Autoimmune enteropathy |
Shwachman syndrome | Wiskott-Aldrich syndrome |
Physiological pancreatic amylase deficiency | Thymic dysplasia |
Enteropathic acrodermatitis | HIV hypoparathyroidism |
Wolman’s disease | Hyperparathyroidism |
Abetalipoproteinemia | Various |
Adrenal insufficiency | Intestinal epithelial dysplasia |
Intestinal hormone hypersecretion | Systemic infection of viral or bacterial origin |
Transcobalamin II deficiency | Phototherapy for hyperbilirubinemia |
Hereditary tyrosinemia | Familial dysautonomia |
Methionine malabsorption | Familial enteropathy |
Diarrhea from medications | |
Necrotizing enterocolitis |