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Management of Uterine Fibroids

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Handbook of Gynecology

Abstract

Uterine fibroids are the most common tumors of the female reproductive tract. It is estimated that the incidence of fibroids by age 35 reaches 40% for Caucasian women and 60% for African American women (Baird and Dunson 2003). Most women with fibroids are asymptomatic; however, symptomatic fibroids remain the most common indication for hysterectomy. In 2010, approximately 196,735 hysterectomies were performed for fibroids in the United States (Wright et al., Obstet Gynecol 122(2 Pt 1):233–241, 2013).

The location of fibroids in the uterus will often determine the type and severity of symptoms a woman will experience. The most common presenting symptoms include infertility, heavy menstrual bleeding, bladder pressure, and pelvic pressure. A thorough history and physical examination along with appropriate imaging can help the clinician tailor the treatment options to improve a patient’s symptoms. As such, the management of fibroids is highly variable.

Expectant management of fibroids is a reasonable option for women who are asymptomatic or not bothered by their symptoms. Medical management can be used for patients desiring to avoid surgery or in preparation for surgery. The surgical management of symptomatic fibroids is broad and includes endometrial ablation, laparoscopic cryomyolysis, laparoscopic uterine artery occlusion, laparoscopic radiofrequency volumetric thermal ablation (LRVTA), myomectomy (abdominal, laparoscopic, or hysteroscopic), and hysterectomy. Radiology-based management options include uterine artery embolization (UAE) and MRI-guided focused ultrasound. Both the UAE and the MRI-guided focused ultrasound require consultation with radiologists.

Despite treatment options available, it is important for the clinician to recognize that not all fibroids require intervention. Counseling patients that fibroids do not have oncogenic potential may also help reassure them and guide their decision-making. Expectant management of fibroids in a stable woman is often an acceptable choice.

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References

  • American Congress of Obstetricians and Gynecologists. Surgical alternatives to hysterectomy in the management of leiomyomas. ACOG Practice Bulletin (Number 16). 2000.

    Google Scholar 

  • Baird DD, Dunson DB. Why is parity protective for uterine fibroids? Epidemiology. 2003;14:247–50.

    PubMed  Google Scholar 

  • Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol. 2003;188:100–7.

    Article  PubMed  Google Scholar 

  • Baird DD, Dunson D, Hill M, Cousins D, Schectman J. Association of physical activity with development of uterine leiomyoma. Am J Epidemiol. 2007;165:157–63.

    Article  PubMed  Google Scholar 

  • Berman JM, Guido RS, Garza Leal JG, Pemueller RR, Whaley FS, Chudnoff SG, Halt Study Group. Three- year outcome of the Halt trial: a prospective analysis of radiofrequency volumetric thermal ablation of myomas. J Minim Invasive Gynecol. 2014;21(5):767–74.

    Google Scholar 

  • Brooks SE, Zhan M, Cote T, Baquet CR. Surveillance, epidemiology, and end results analysis of 2677 cases of uterine sarcoma 1989–1999. Gynecol Oncol. 2004;93:204–8.

    Article  Google Scholar 

  • Cantuaria GH, Angioli R, Frost L, Duncan R, Penalver MA. Comparison of bimanual examination with ultrasound examination before hysterectomy for uterine leiomyoma. Obstet Gynecol. 1998;92:109–12.

    Article  CAS  PubMed  Google Scholar 

  • Chrisman HB, Saker MB, Ryu RK, Nemcek Jr AA, Gerbie MV, Milad MP, Smith SJ, Sewall LE, Omary RA, Vogelzang RL. The impact of uterine fibroid embolization on resumption of menses and ovarian function. J Vasc Interv Radiol. 2000;11(6):699.

    Article  CAS  PubMed  Google Scholar 

  • Chudnoff SG, Berman JM, Levine DJ, Harris M, Guido RS, Banks E. Outpatient procedure for the treatment and relief of symptomatic myomas. Obstet Gynecol. 2013;121(5):1075–82.

    Article  PubMed  Google Scholar 

  • Cramer SF, Patel A. The frequency of uterine leiomyomas. Am J Clin Pathol. 1990;94(4):435.

    Article  CAS  Google Scholar 

  • Donnez J, Squifflet J, Polet R, Nisolle M. Laparoscopic myolysis. Hum Reprod Update. 2000;6:609–13.

    Article  CAS  PubMed  Google Scholar 

  • Donnez J, Tatarchuk TF, Bouchard P, Puscasiu L, Zakharenko NF, Ivanova T, Ugocsai G, Mara M, Jilla MP, Bestel E, Terrill P, Osterloh I, Loumaye E, PEARL I Study Group. Ulipristal acetate versus placebo for fibroid treatment before surgery. N Engl J Med. 2012;366(5):409–20.

    Article  CAS  PubMed  Google Scholar 

  • Dueholm M, Lundorf E, Hansen ES, Ledertoug S, Olesen F. Evaluation of the uterine cavity with magnetic resonance imaging, transvaginal sonography, hysterosonographic examination, and diagnostic hysteroscopy. Fertil Steril. 2001;76:350–7.

    Article  CAS  PubMed  Google Scholar 

  • Dueholm M, Lundorf E, Hansen ES, Ledertoug S, Olesen F. Accuracy of magnetic resonance imaging and transvaginal ultrasonography in the diagnosis, mapping, and measurement of uterine myomas. Am J Obstet Gynecol. 2002a;186:409–15.

    Article  PubMed  Google Scholar 

  • Dueholm M, Lundorf E, Sorensen JS, Ledertoug S, Olesen F, Laursen H. Reproducibility of evaluation of the uterus by transvaginal sonography, hysterosonographic examination, hysteroscopy and magnetic resonance imaging. Hum Reprod. 2002b;17:195–200.

    Article  PubMed  Google Scholar 

  • Edwards RD, Moss JG, Lumsden MA, Wu O, Murray LS, Twaddle S, Murray GD. Committee of the randomized trial of embolization versus surgical treatment for fibroids. Uterine-artery embolization versus surgery for symptomatic uterine fibroids. N Engl J Med. 2007;356(4):360.

    Article  CAS  PubMed  Google Scholar 

  • Frederick J, Fletcher H, Simeon D, Mullings A, Hardie M. Intramyometrial vasopressin as a haemostatic agent during myomectomy. Br J Obstet Gynaecol. 1994;101:435–7.

    Article  CAS  PubMed  Google Scholar 

  • Friedman AJ, Hoffman DI, Comite F, Browneller RW, Miller JD. Treatment of leiomyomata uteri with leuprolide acetate depot: a double-blind, placebo-controlled, multicenter study. The Leuprolide Study Group. Obstet Gynecol. 1991;77:720–5.

    CAS  PubMed  Google Scholar 

  • Goto A, Takeuchi S, Sugimura K, Maruo T. Usefulness of Gd-DTPA contrast-enhanced dynamic MRI and serum determination of LDH and its isozymes in the differential diagnosis of leiomyosarcoma from degenerated leiomyoma of the uterus. Int J Gynecol Cancer. 2002;12:354–61.

    Article  CAS  PubMed  Google Scholar 

  • Grigorieva V, Chen-Mok M, Tarasova M, Mikhailov A. Use of a levonorgestrel-releasing intrauterine system to treat bleeding related to uterine leiomyomas. Fertil Steril. 2003;79:1194–8.

    Article  PubMed  Google Scholar 

  • Gurtcheff SE, Sharp HT. Complications associated with global endometrial ablation: the utility of the MAUDE database. Obstet Gynecol. 2003;102:1278–82.

    PubMed  Google Scholar 

  • Harris JA, Swenson CW, Uppal S, Kamdar N, Mahnert N, As- Sanine S, Morgan DM. Practice patterns and postoperative complications before and after US Food and Drug Administration safety communication on power morcellation. Am J Obstet Gynecol. 2016;214(1):98.e1–98.e13.

    Article  Google Scholar 

  • Hart R, Molnár BG, Magos A. Long term follow up of hysteroscopic myomectomy assessed by survival analysis. Br J Obstet Gynaecol. 1999;106(7):700.

    Article  CAS  PubMed  Google Scholar 

  • Hindley J, Gedroyc WM, Regan L, Stewart E, Tempany C, Hynyen K, et al. MRI guidance of focused ultrasound therapy of uterine fibroids: early results. Am J Roentgenol. 2004;183:1713–9.

    Article  Google Scholar 

  • Holub Z, Jabor A, Lukac J, Kliment L, Urbanek S. Midterm follow-up study of laparoscopic dissection of uterine vessels for treatment of symptomatic fibroids. Surg Endosc. 2004;9:1349–53.

    Article  Google Scholar 

  • Huyck KL, Panhuysen CI, Cuenco KT, Zhang J, Goldhammer H, Jones ES, Somasundaram P, Lynch AM, Harlow BL, Lee H, Stewart EA, Morton CC. The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters. Am J Obstet Gynecol. 2008;198(2):168.

    Article  PubMed Central  Google Scholar 

  • Indman PD. Hysteroscopic treatment of menorrhagia associated with uterine leiomyomas. Obstet Gynecol. 1993;81:716–20.

    CAS  PubMed  Google Scholar 

  • Kaligiannidis I. Intravaginal misoprostol reduces intraoperative blood loss in minimally invasive myomectomy: a randomized clinical trial. Clin Exp Obstet Gynecol. 2011;38(1):46–9.

    Google Scholar 

  • Langer R, Golan A, Neuman M, Schneider D, Bukovsky I, Caspi E. The effect of large uterine fibroids on urinary bladder function and symptoms. Am J Obstet Gynecol. 1990;163:1139–41.

    Article  CAS  PubMed  Google Scholar 

  • Leather AT, Studd JW, Watson NR, Holland EF. The prevention of bone loss in young women treated with GnRH analogues with “add-back” estrogen therapy. Obstet Gynecol. 1993;81:104–7.

    CAS  PubMed  Google Scholar 

  • Leppert PC, Catherino WH, Segars JH. A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays. Am J Obstet Gynecol. 2006;195:415–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lethaby A, Vollenhoven B, Sowter M. Efficacy of pre-operative gonadotrophin hormone releasing analogues for women with uterine fibroids undergoing hysterectomy or myomectomy: a systematic review. BJOG. 2002;109:1097–108.

    Article  CAS  Google Scholar 

  • Lippman SA, Warner M, Samuels S, Olive D, Vercellini P, Eskenazi B. Uterine fibroids and gynecologic pain symptoms in a population-based study. Fertil Steril. 2003;80:1488–94.

    Article  PubMed  Google Scholar 

  • Loffer FD, Bradley LD, Brill AI, Brooks PG, Cooper JM. Hysteroscopic fluid monitoring guidelines. The ad hoc committee on hysteroscopic training guidelines of the American Association of Gynecologic Laparoscopists. J Am Assoc Gynecol Laparosc. 2000;7:167–8.

    Article  CAS  PubMed  Google Scholar 

  • Lumbiganon P, Rugpao S, Phandhu-fung S, Laopaiboon M, Vudhikamraksa N, Werawatakul Y. Protective effect of depot-medroxyprogesterone acetate on surgically treated uterine leiomyomas: a multicentre case–control study. Br J Obstet Gynaecol. 1996;103:909–14.

    Article  CAS  PubMed  Google Scholar 

  • Malone L. Myomectomy: recurrence after removal of solitary and multiple myomas. Obstet Gynecol. 1969;34:200–3.

    CAS  PubMed  Google Scholar 

  • Management of Uterine Fibroids. Summary, Evidence Report/Technology Assessment: Number 34. AHRQ Publication No. 01-E051, January 2001. Agency for Healthcare Research and Quality, Rockville.

    Google Scholar 

  • Marshall LM, Spiegelman D, Barbieri RL, Goldman MB, Manson JE, Colditz GA, et al. Variation in the incidence of uterine leiomyoma among premenopausal women by age and race. Obstet Gynecol. 1997;90:967–73.

    Article  CAS  PubMed  Google Scholar 

  • Marshall LM, Spiegelman D, Goldman MB, Manson JE, Colditz GA, Barbieri RL, et al. A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata. Fertil Steril. 1998;70:432–9.

    Article  CAS  PubMed  Google Scholar 

  • Michnovicz JJ, Hershcopf RJ, Naganuma H, Bradlow HL, Fishman J. Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking. N Engl J Med. 1986;315:1305–9.

    Article  CAS  PubMed  Google Scholar 

  • Moorman PG. Effect of hysterectomy with ovarian preservation on ovarian function. Obstet Gynecol. 2011;118(6):1271–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Munro MG, Critchley HO, Broder MS, Fraser IS. The FIGO Classifi cation System (“PALM-COEIN”) for causes of abnormal uterine bleeding in non-gravid women in the reproductive years, including guidelines for clinical investigation. Int J Gynaecol Obstet. 2011;113:3–13.

    Article  PubMed  Google Scholar 

  • Parazzini F, Negri E, La Vecchia C, Chatenoud L, Ricci E, Guarnerio P. Reproductive factors and risk of uterine fibroids. Epidemiology. 1996;7:440–2.

    Article  CAS  PubMed  Google Scholar 

  • Parker W, Fu Y, Berek J. Uterine sarcoma in patients operated on for presumed leiomyoma and rapidly growing leiomyoma. Obstet Gynecol. 1994;83:414–8.

    CAS  PubMed  Google Scholar 

  • Peddada SD, Laughlin SK, Miner K, Guyon JP, Haneke K, Vahdat HL, Semelka RC, Kowalik A, Armao D, Davis B, Baird DD. Growth of uterine leiomyomata among premenopausal black and white women. Proc Natl Acad Sci U S A. 2008;105(50):19887–92.

    Article  CAS  PubMed Central  Google Scholar 

  • Pritts E, Parker W, Olive D. Fibroids and infertility: an updated systematic review of the evidence. Fertil Steril. 2009;91:1215–23.

    Article  Google Scholar 

  • Pritts EA, Vanness DJ, Berek JS, Parker W, Feinberg R, Feinberg J, Olive DL. The prevalence of occult leiomyosarcoma at surgery for presumed uterine fibroids: a meta-analysis. Gynecol Surg. 2015;12(3):165–77. Epub 2015 May 19.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pron G, Bennett J, Common A, Wall J, Asch M, Sniderman K. The Ontario uterine fibroid embolization trial. Part 2. Uterine fibroid reduction and symptom relief after uterine artery embolization for fibroids. Fertil Steril. 2003;79:120–7.

    Article  PubMed  Google Scholar 

  • Puri K, Famuyide AO, Erwin PJ, Stewart EA, Laughlin-Tommaso SK. Submucosal fibroids and the relation to heavy menstrual bleeding and anemia. Am J Obstet Gynecol. 2014;210(1):38.e1–7. Epub 2013 Sep 28.

    Article  Google Scholar 

  • Quade BJ, Wang TY, Sornberger K, Dal Cin P, Mutter GL, Morton CC. Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling. Genes Chromosomes Cancer. 2004;40:97–108.

    Article  CAS  PubMed  Google Scholar 

  • Ross RK, Pike MC, Vessey MP, Bull D, Yeates D, Casagrande JT. Risk factors for uterine fibroids: reduced risk associated with oral contraceptives. Br Med J (Clin Res Ed). 1986;293:359–62.

    Article  CAS  Google Scholar 

  • Ryu RK, Chrisman HB, Omary RA, Miljkovic S, Nemcek Jr AA, Saker MB, et al. The vascular impact of uterine artery embolization: prospective sonographic assessment of ovarian arterial circulation. J Vasc Interv Radiol. 2001;12:1071–4.

    Article  CAS  PubMed  Google Scholar 

  • Sawin SW, Pilevsky ND, Berlin JA, Barnhart KT. Comparability of perioperative morbidity between abdominal myomectomy and hysterectomy for women with uterine leiomyomas. Am J Obstet Gynecol. 2000;183:1448–55.

    Article  CAS  PubMed  Google Scholar 

  • Schlaff WD, Zerhouni EA, Huth JA, Chen J, Damewood MD, Rock JA. A placebo-controlled trial of a depot gonadotropin-releasing hormone analogue (leuprolide) in the treatment of uterine leiomyomata. Obstet Gynecol. 1989;74:856–62.

    CAS  Google Scholar 

  • Segars JH, Parrott EC, Nagel JD, Guo XC, Gao X, Birnbaum LS, Pinn VW, Dixon D. Proceedings from the Third National Institutes of Health International Congress on advances in uterine leiomyoma research: comprehensive review, conference summary and future recommendations. Hum Reprod Update. 2014;20(3):309–33.

    Article  PubMed  PubMed Central  Google Scholar 

  • Shaaban MM, Ahmed MR, Farhan RE, Dardeer HH. Efficacy of tranexamic acid on myomectomy-associated blood loss in patients with multiple myomas: a randomized controlled clinical trial. Reprod Sci. 2015 Dec 29. pii: 1933719115623646.

    Google Scholar 

  • Soysal S, Soysal M. The efficacy of levonorgestrel-releasing intrauterine device in selected cases of myoma-related menorrhagia: a prospective controlled trial. Gynecol Obstet Invest. 2005;59:29–35.

    Article  PubMed  Google Scholar 

  • Steinauer J, Pritts EA, Jackson R, Jacoby AF. Systematic review of mifepristone for the treatment of uterine leiomyomata. Obstet Gynecol. 2004;103:1331–6.

    Article  CAS  PubMed  Google Scholar 

  • Stewart EA, Nowak RA. Leiomyoma-related bleeding: a classic hypothesis updated for the molecular era. Hum Reprod Update. 1996;2(4):295.

    Article  CAS  PubMed  Google Scholar 

  • Stewart EA, Rabinovici J, Tempany CM, Inbar Y, Regan L, Gastout B, et al. Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids. Fertil Steril. 2006;85:22–9.

    Article  PubMed  Google Scholar 

  • Stovall TG, Muneyyirci-Delale O, Summitt Jr RL, Scialli AR. GnRH agonist and iron versus placebo and iron in the anemic patient before surgery for leiomyomas: a randomized controlled trial. Leuprolide Acetate Study Group. Obstet Gynecol. 1995;86:65–71.

    Article  CAS  PubMed  Google Scholar 

  • UPDATED Laparoscopic Uterine Power Morcellation in Hysterectomy and Myomectomy: FDA Safety Communication. April 17, 2015. Available at: http://www.fda.gov/medicaldevices/safety/alertsandnotices/ucm424443.htm

  • Vikhlyaeva EM, Khodzhaeva ZS, Fantschenko ND. Familial predisposition to uterine leiomyomas. Int J Gynaecol Obstet. 1995;51:127–31.

    Article  CAS  PubMed  Google Scholar 

  • Wong AS, Cheung CW, Yeung SW, Fan HL, Leung TY, Sahota DS. Transcervical intralesional vasopressin injection compared with placebo in hysteroscopic myomectomy: a randomized controlled trial. Obstet Gynecol. 2014;124(5):897–903.

    Article  CAS  PubMed  Google Scholar 

  • Wright JD, Herzog TJ, Ananth CV, Lewin SN, Lu YS, Neugut AI, Hershman DL. Nationwide trends in the performance of inpatient hysterectomy in the United States. Obstet Gynecol. 2013;122(2 Pt 1):233–41.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wurnig C, Schatz K, Noske H, Hemon Y, Dahlberg G, Josefsson G, et al. Subcutaneous low-dose epoetin beta for the avoidance of transfusion in patients scheduled for elective surgery not eligible for autologous blood donation. Eur Surg Res. 2001;33:303–10.

    Article  CAS  Google Scholar 

  • Yamada T, Ikeda A, Okamoto Y, Okamoto Y, Kanda T, Ueki M. Intraoperative blood salvage in abdominal simple total hysterectomy for uterine myoma. Int J Gynaecol Obstet. 1997;59:233–6.

    Article  CAS  PubMed  Google Scholar 

  • Zupi E, Marconi D, Sbracia M, Exacoustos C, Piredda A, Sorrento G, et al. Directed laparoscopic cryomyolysis for symptomatic leiomyoma: one-year follow up. J Minim Invasive Gynecol. 2005;12:343–6.

    Article  PubMed  Google Scholar 

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Correspondence to Valentina M. Rodriguez-Triana or William H. Parker .

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Rodriguez-Triana, V.M., Parker, W.H. (2017). Management of Uterine Fibroids. In: Shoupe, D. (eds) Handbook of Gynecology. Springer, Cham. https://doi.org/10.1007/978-3-319-17798-4_80

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