Brain Lesion Studies
Studies of brain anatomical-physiological relationships that focus on investigating the physical or cognitive effects of clearly delineated lesions, i.e., damage to tissue from disease, injury, or malformation.
Some of the earliest brain lesion studies were done in subjects with a specific impairment, usually of language, and were mapped to the relevant region of damage via postmortem studies. Modern brain lesion studies, which investigate a range of functional impairments, including language, motor, and cognition, usually rely on in vivo neuroimaging to detect, quantify, and map brain lesions to their associated impairments.
Historical Brain Lesion Studies
One of the first examples of a brain lesion study was in the famous patient nicknamed “Tan,” as this was the only word this patient was able to say. This patient, Louis Victor Leborgne, suffered from epilepsy and, as it was discovered after his...
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