An excessive pathological reaction of the immune system towards environmental substances, such as foods and pollens, that are tolerated by the immune system of nonallergic individuals.
Allergies have become increasingly prevalent over recent decades, particularly in the West. As a consequence, interest has grown regarding why such a phenomenon exists in the first place, especially given the risk of experiencing a potentially fatal allergic reaction called anaphylaxis (Gross 2015). Early explanations typically viewed allergies as merely immunological errors. However, the evolutionary persistence of allergic capability suggests that it has an adaptive value for the host, of which exerted a strong enough positive selection pressure to outweigh the physiological costs and risk of fatality. Margie Profet became a notable theorist for why allergies evolved with her controversial hypothesis regarding what this benefit of allergies may have...
KeywordsAllergy Symptom Positive Selection Pressure Honeybee Venom Bronchial Constriction Darwinian Medicine
- Amirian, E. S., Zhou, R., Wrensch, M. R., Olson, S. H., Scheurer, M. E., Il’Yasova, D., … Bondy, M. L. (2016). Approaching a scientific consensus on the association between allergies and glioma risk: A report from the glioma international case–control study. Cancer Epidemiology Biomarkers & Prevention, 25(2), 282–290. doi:10.1158/1055-9965.EPI-15-0847Google Scholar
- Il’yasova, D., McCarthy, B., Marcello, J., Schildkraut, J. M., Moorman, P. G., Krishnamachari, B., … Davis, F. (2009). Association between glioma and history of allergies, asthma, and eczema: A case–control study with three groups of controls. Cancer Epidemiology Biomarkers & Prevention, 18(4), 1232–1238. doi:10.1158/1055-9965.EPI-08-0995Google Scholar
- Marichal, T., Starkl, P., Reber, L. L., Kalesnikoff, J., Oettgen, H. C., Tsai, M., … Galli, S. J. (2013). A beneficial role for immunoglobulin E in host defense against honeybee venom. Immunity, 39(5), 963–975. doi:10.1016/j.immuni.2013.10.005Google Scholar