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Encyclopedia of Evolutionary Psychological Science pp 1–6Cite as

MHC Compatibility

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Synonyms

Human leukocyte antigen (HLA) system; Major histocompatibility complex (MHC)

Definition

The Major Histocompatibility Complex (MHC) refers to a large, highly dense genomic region found in most vertebrates which encodes proteins that display both self- and non-self antigens to white blood cells called T cells that can eliminate pathogens or malfunctioning cells. In humans, the MHC is also called the Human Leukocyte Antigen (HLA) system. MHC Compatibility refers to the role of the MHC in mate selection.

Introduction

Since the debut of major histocompatibility complex- (MHC) dependent mate preferences in mice in 1976 (Yamazaki et al.), a number of studies have been conducted to determine the role of MHC across species, identify mechanisms of MHC identification, and distinguish among hypotheses about the adaptive significance of having this ability. Three main hypotheses have been suggested (discussed in Penn and Potts 1999): first, that dissortative mating on MHC genotypes...

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References

  • Beauchamp, G. K., Yamazaki, K., Bard, J., & Boyse, E. A. (1988). Preweaning experience in the control of mating prefrences by genes in the major histocompatibility complex of the mouse. Behavior Genetics, 18, 537–547.

    CrossRef  Google Scholar 

  • Beck, S., & Trowsdale, J. (2000). The human major histocompatibility complex: Lessons from the DNA sequence. Annual Review of Genomics and Human Genetics, 1, 117–137.

    CrossRef  Google Scholar 

  • Carrington, M., Nelson, G. W., Martin, M. P., Kissner, T., Vlahov, D., Goedert, J. J., Kaslow, R., Buchbinder, S., Hoots, K., & O’Brien, S. J. (1999). HLA and HIV-1: Heterozygote advantage and B*35-Cw*04 disadvantage. Science, 283, 1748–1752.

    CrossRef  Google Scholar 

  • Egid, K., & Brown, J. L. (1989). The major histocompatibility complex and female mating preferences in mice. Animal Behaviour, 38, 548–549.

    CrossRef  Google Scholar 

  • Eizaguirre, C., Yeates, S. E., Lenz, T. L., Kalbe, M., & Milinski, M. (2009). MHC-based mate choice combines good genes and maintenance of MHC polymorphism. Molecular Ecology, 18, 3316–3329.

    CrossRef  Google Scholar 

  • Havlicek, J., & Roberts, S. C. (2009). MHC-correlated mate choice in humans: A review. Psychoneuroendocrinology, 34, 497–512.

    CrossRef  Google Scholar 

  • Hedrick, P. W. (1992). Female choice and variation in the major histocompatibility complex. Genetics, 132, 575–581.

    PubMed  PubMed Central  Google Scholar 

  • Jacob, S., McClintock, M. K., Zelano, B., & Ober, C. (2002). Paternally inherited HLA alleles are associated with women’s choice of male odor. Nature Genetics, 30, 175–179.

    CrossRef  Google Scholar 

  • Janeway, C. A., Travers, P., Walport, M., & Shlomchik, M. (2001). Immunobiology. New York: Garland Science.

    Google Scholar 

  • Ober, C. (1992). The maternal-fetal relationship in human pregnancy: An immunological perspective. Experimental and Clinical Immunogenetics, 9, 1–14.

    PubMed  Google Scholar 

  • Ober, C., Weitkamp, L. R., Cox, N., Dytch, H., Kostyu, D., & Elias, S. (1997). HLA and mate choice in humans. American Journal of Human Genetics, 61, 497–504.

    CrossRef  Google Scholar 

  • Pause, B. M., Sojka, B., Krauel, K., Fehm-Wolfsdorf, G., & Ferstl, R. (1996). Olfactory information processing during the course of the menstrual cycle. Biological Psychology, 44, 31–54.

    CrossRef  Google Scholar 

  • Penn, D. J., & Potts, W. K. (1999). The evolution of mating preferences and major histocompatibility complex genes. The American Naturalist, 153(2), 145–164.

    CrossRef  Google Scholar 

  • Penn, D. J., Oberzaucher, E., Grammer, K., Fischer, G., Soini, H. A., Wiesler, D., Novotny, M. V., Dixon, S. J., Xu, Y., & Brereton, R. G. (2007). Individual and gender fingerprints in human body odour. Journal of the Royal Society Interface, 4, 331–340.

    CrossRef  Google Scholar 

  • Petrinovich, L. (1979). Probabilistic functionalism: A conception of research method. American Psychologist, 34(5), 373–390.

    CrossRef  Google Scholar 

  • Potts, W. K. (2002). Wisdom through immunogenetics. Nature Genetics, 30, 130–131.

    CrossRef  Google Scholar 

  • Roberts, S. C. (2009). Complexity and context of MHC-correlated mating preferences in wild populations. Molecular Ecology, 18(15), 3121–3123.

    CrossRef  Google Scholar 

  • Roberts, S. C., Gosling, L. M., Spector, T. D., Miller, P., Penn, D. J., & Petrie, M. (2005). Body odor similarity in noncohabiting twins. Chemical Senses, 30, 651–656.

    CrossRef  Google Scholar 

  • Roberts, S. C., Gosling, L. M., Carter, V., & Petrie, M. (2008). MHC-correlated odour preferences in humans and the use of oral contraceptives. Proceedings of the Royal Society of London B: Biological Sciences, 275(1652), 2715–2722.

    Google Scholar 

  • Schaefer, M. L., Young, D. A., & Restrepo, D. (2001). Olfactory fingerprints for major histocompatibility complex-determined body odors. The Journal of Neuroscience, 21, 2481–2487.

    CrossRef  Google Scholar 

  • Schaefer, M. L., Yamazaki, K., Osada, K., Restrepo, D., & Beauchamp, G. K. (2002). Olfactory fingerprints for major histocompatibility complex determined odors II: Relationship among odor maps, genetics, odor composition, and behavior. The Journal of Neuroscience, 22(21), 9513–9521.

    CrossRef  Google Scholar 

  • Singer, A. G., Beauchamp, G. K., & Yamazaki, K. (1997). Volatile signals of the major histocompatibility complex in male mouse urine. Proceedings of the National Academy of Sciences, 94(6), 2210–2214.

    CrossRef  Google Scholar 

  • Singh, P. B., Herbert, J., Roser, B., Arnott, L., Tucker, D., & Brown, R. (1990). Rearing rats in a germ-free environment eliminates their odors of individuality. Journal of Chemical Ecology, 16, 1667–1682.

    CrossRef  Google Scholar 

  • Wedekind, C., & Furi, S. (1997). Body odour preferences in men and women: Do they aim for specific MHC combinations or simply heterozygosity? Proceedings of the Royal Society of London B: Biological Sciences, 264(1387), 1471–1479.

    CrossRef  Google Scholar 

  • Wedekind, C., Seeback, T., Bettens, F., & Paepke, A. J. (1995). MHC-dependent mate preferences in humans. Proceedings of the Royal Society of London B, 260(1359), 245–249.

    CrossRef  Google Scholar 

  • Wedekind, C., Chapuisat, M., Macas, E., & Rulicke, T. (1996). Non-random fertilization in mice correlates with MHC and something else. Heredity, 77, 400–409.

    CrossRef  Google Scholar 

  • Weidt, G., Deppert, W., Utermohlen, O., Heukeshoven, J., & Lehmann-Grube, F. (1995). Emergence of virus escape mutants after immunization with epitope vaccine. Journal of Virology, 69, 7147–7151.

    PubMed  PubMed Central  Google Scholar 

  • Yamazaki, K. E., Boyse, A., Mike, V., Thaler, T., Mathieson, B. J., Abbott, J., Boyse, J., & Zayas, Z. A. (1976). Control of mating preferences in mice by genes in the major histocompatibility complex. Journal of Experimental Medicine, 144, 1324–1335.

    CrossRef  Google Scholar 

  • Yamazaki, K., Beauchamp, G. K., Kupniewski, D., Bard, J., & Thomas, L. (1988). Familial imprinting determines H-2 selective mating preferences. Science, 240, 1331–1332.

    CrossRef  Google Scholar 

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Authors and Affiliations

  1. Department of Psychology, Arizona State University - West Campus, Phoenix, AZ, USA

    Candace Jasmine Black

  2. Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA

    Tomás Cabeza de Baca

Authors
  1. Candace Jasmine Black
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  2. Tomás Cabeza de Baca
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Correspondence to Candace Jasmine Black .

Editor information

Editors and Affiliations

  1. Department of Psychology, Oakland University, Rochester, MI, USA

    Dr. Todd K. Shackelford

  2. Rochester, MI, USA

    Viviana A. Weekes-Shackelford

Section Editor information

  1. University of Nicosia, Nicosia, Cyprus

    Menelaos Apostolou

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Black, C.J., Cabeza de Baca, T. (2018). MHC Compatibility. In: Shackelford, T., Weekes-Shackelford, V. (eds) Encyclopedia of Evolutionary Psychological Science. Springer, Cham. https://doi.org/10.1007/978-3-319-16999-6_1013-1

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  • DOI: https://doi.org/10.1007/978-3-319-16999-6_1013-1

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