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Photodynamic Therapy for Acne

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Abstract

Acne is a common disease that affects a large part of the young population. Common treatments for moderate acne include the use of oral antibiotics. However, there is an increased risk of antibiotic resistance. Furthermore, the environmental effects of these drugs may be severe. Hence there is an alternative for treatment of moderate acne. Photodynamic therapy (PDT) seems to have a good effect. However, treatment parameters need to be elaborated upon as possibly the choice of photosensitizer in the future. Pain is a cumbersome side effect but may be controlled by easy measures.

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References

  • Asayama-Kosaka S, Akilov OE, Kawana S. Photodynamic therapy with 5% delta-aminolevulinic acid is safe and effective treatment of acne vulgaris in Japanese patients. Laser Therapy. 2014;23(2):115–20.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cunliffe WJ. Acne and unemployment. Br J Dermatol. 1986;115(3):386.

    Article  CAS  PubMed  Google Scholar 

  • Das S, Reynolds RV. Recent advances in acne pathogenesis: implications for therapy. Am J Clin Dermatol. 2014;15(6):479–88.

    Article  PubMed  Google Scholar 

  • Divaris DX, Kennedy JC, Pottier RH. Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence. Am J Pathol. 1990;136(4):891–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Dong Y et al. A new LED device used for photodynamic therapy in treatment of moderate to severe acne vulgaris. Photodiagnosis Photodyn Ther. 2016;13:188–95. doi: 10.1016/j.pdpdt.2015.06.007. Epub 2015 Jun 23.

    Google Scholar 

  • Dougherty TJ, et al. Photoradiation therapy for the treatment of malignant tumors. Cancer Res. 1978;38(8):2628–35.

    CAS  PubMed  Google Scholar 

  • Ericson MB, et al. Fluorescence contrast and threshold limit: implications for photodynamic diagnosis of basal cell carcinoma. J Photochem Photobiol B. 2003;69(2):121–7.

    Article  CAS  PubMed  Google Scholar 

  • Grapengiesser S, et al. Pain caused by photodynamic therapy of skin cancer. Clin Exp Dermatol. 2002;27(6):493–7.

    Article  CAS  PubMed  Google Scholar 

  • Guffey JS, Wilborn J. In vitro bactericidal effects of 405-nm and 470-nm blue light. Photomed Laser Surg. 2006;24(6):684–8.

    Article  PubMed  Google Scholar 

  • Haedersdal M, Togsverd-Bo K, Wulf HC. Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris. J Eur Acad Dermatol Venereol. 2008;22(3):267–78.

    Article  CAS  PubMed  Google Scholar 

  • Hong JS, et al. Acne treatment by methyl aminolevulinate photodynamic therapy with red light vs. intense pulsed light. Int J Dermatol. 2013;52(5):614–9.

    Article  CAS  PubMed  Google Scholar 

  • Hongcharu W, et al. Topical ALA-photodynamic therapy for the treatment of acne vulgaris. J Invest Dermatol. 2000;115(2):183–92.

    Article  CAS  PubMed  Google Scholar 

  • Horfelt C, et al. Photodynamic therapy for acne vulgaris: a pilot study of the dose-response and mechanism of action. Acta Derm Venereol. 2007;87(4):325–9.

    Article  PubMed  Google Scholar 

  • Horfelt C, et al. Single low-dose red light is as efficacious as methyl-aminolevulinate – photodynamic therapy for treatment of acne: clinical assessment and fluorescence monitoring. Acta Derm Venereol. 2009;89(4):372–8.

    Article  PubMed  Google Scholar 

  • Ibbotson SH. Adverse effects of topical photodynamic therapy. Photodermatol Photoimmunol Photomed. 2011;27(3):116–30.

    Article  PubMed  Google Scholar 

  • Jang MS, et al. A comparative split-face study of photodynamic therapy with indocyanine green and indole-3-acetic acid for the treatment of acne vulgaris. Br J Dermatol. 2011;165(5):1095–100.

    Article  CAS  PubMed  Google Scholar 

  • Jeong E, et al. Topical ALA-photodynamic therapy for acne can induce apoptosis of sebocytes and down-regulate their TLR-2 and TLR-4 expression. Ann Dermatol. 2011;23(1):23–32.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kosaka S, et al. Targeting of sebaceous glands by delta-aminolevulinic acid-based photodynamic therapy: an in vivo study. Lasers Surg Med. 2011;43(5):376–81.

    Article  PubMed  Google Scholar 

  • Li X, et al. Effects of 5-aminolevulinic acid-mediated photodynamic therapy on antibiotic-resistant staphylococcal biofilm: an in vitro study. J Surg Res. 2013;184(2):1013–21.

    Article  CAS  PubMed  Google Scholar 

  • Linkner RV, et al. Evaluating the efficacy of photodynamic therapy with 20% aminolevulinic acid and microdermabrasion as a combination treatment regimen for acne scarring: a split-face, randomized, double-blind pilot study. J Clin Aesth Dermatol. 2014;7(5):32–5.

    Google Scholar 

  • Liu LH, et al. Randomized trial of three phototherapy methods for the treatment of acne vulgaris in Chinese patients. Photodermatol Photoimmunol Photomed. 2014;30(5):246–53.

    Article  PubMed  Google Scholar 

  • Mei X, Shi W, Piao Y. Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light in Chinese acne vulgaris patients. Photodermatol Photoimmunol Photomed. 2013;29(2):90–6.

    Article  CAS  PubMed  Google Scholar 

  • Morton CA, et al. An open study to determine the efficacy of blue light in the treatment of mild to moderate acne. J Dermatolog Treat. 2005;16(4):219–23.

    Article  CAS  PubMed  Google Scholar 

  • Na JI, Suh DH. Red light phototherapy alone is effective for acne vulgaris: randomized, single-blinded clinical trial. Dermatol Surg. 2007;33(10):1228–33. discussion 1233.

    CAS  PubMed  Google Scholar 

  • Neittaanmaki-Perttu N, et al. Daylight photodynamic therapy for actinic keratoses: a randomized double-blinded nonsponsored prospective study comparing 5-aminolaevulinic acid nanoemulsion (BF-200) with methyl-5-aminolaevulinate. Br J Dermatol. 2014;171(5):1172–80.

    Article  CAS  PubMed  Google Scholar 

  • Paoli J, et al. Nerve blocks provide effective pain relief during topical photodynamic therapy for extensive facial actinic keratoses. Clin Exp Dermatol. 2008;33(5):559–64.

    Article  CAS  PubMed  Google Scholar 

  • Papageorgiou P, Katsambas A, Chu A. Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris. Br J Dermatol. 2000;142(5):973–8.

    Article  CAS  PubMed  Google Scholar 

  • Peng Q, et al. Distribution and photosensitizing efficiency of porphyrins induced by application of exogenous 5-aminolevulinic acid in mice bearing mammary carcinoma. Int J Cancer. 1992;52(3):433–43.

    Article  CAS  PubMed  Google Scholar 

  • Pinto C, et al. Efficacy of red light alone and methyl-aminolaevulinate-photodynamic therapy for the treatment of mild and moderate facial acne. Indian J Dermatol Venereol Leprol. 2013;79(1):77–82.

    Article  PubMed  Google Scholar 

  • Pollock B, et al. Topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action. Br J Dermatol. 2004;151(3):616–22.

    Article  CAS  PubMed  Google Scholar 

  • Romiti R, et al. High-performance liquid chromatography analysis of porphyrins in Propionibacterium acnes. Arch Dermatol Res. 2000;292(6):320–2.

    Article  CAS  PubMed  Google Scholar 

  • Sadick N. A study to determine the effect of combination blue (415 nm) and near-infrared (830 nm) light-emitting diode (LED) therapy for moderate acne vulgaris. J Cosmet Laser Ther. 2009;11(2):125–8.

    Article  PubMed  Google Scholar 

  • Sandberg C, et al. Bioavailability of aminolaevulinic acid and methylaminolaevulinate in basal cell carcinomas: a perfusion study using microdialysis in vivo. Br J Dermatol. 2008;159(5):1170–6.

    CAS  PubMed  Google Scholar 

  • Sigurdsson V, Knulst AC, van Weelden H. Phototherapy of acne vulgaris with visible light. Dermatology. 1997;194(3):256–60.

    Article  CAS  PubMed  Google Scholar 

  • Song BH, et al. Photodynamic therapy using chlorophyll-a in the treatment of acne vulgaris: a randomized, single-blind, split-face study. J Am Acad Dermatol. 2014;71(4):764–71.

    Article  CAS  PubMed  Google Scholar 

  • Thiboutot D. Dermatologists do not yet fully understand the clinical significance of antibiotic use and bacterial resistance in patients with acne: comment on “Antibiotics, acne, and Staphylococcus aureus colonization. Arch Dermatol. 2011;147(8):921–2.

    Article  PubMed  Google Scholar 

  • Wiegell SR, Wulf HC. Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate. J Am Acad Dermatol. 2006;54(4):647–51.

    Article  PubMed  Google Scholar 

  • Yin R, et al. Combination ALA-PDT and ablative fractional Er:YAG laser (2,940 nm) on the treatment of severe acne. Lasers Surg Med. 2014;46(3):165–72.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zheng W, et al. Evidence-based review of photodynamic therapy in the treatment of acne. Eur J Dermatol. 2014;24(4):444–56.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 45, Gothenburg, Sweden

    Ann-Marie Wennberg Larkö

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  1. Ann-Marie Wennberg Larkö
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Correspondence to Ann-Marie Wennberg Larkö .

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Editors and Affiliations

  1. Department of Clinical Medicine – Dermatology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil

    Maria Claudia Almeida Issa

  2. Clínicas Hospital of São Paulo of the University of Sao Paulo, Sao Paulo, São Paulo, Brazil

    Bhertha Tamura

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Wennberg Larkö, AM. (2018). Photodynamic Therapy for Acne. In: Issa, M., Tamura, B. (eds) Lasers, Lights and Other Technologies. Clinical Approaches and Procedures in Cosmetic Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-16799-2_25

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  • DOI: https://doi.org/10.1007/978-3-319-16799-2_25

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-16798-5

  • Online ISBN: 978-3-319-16799-2

  • eBook Packages: MedicineReference Module Medicine

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