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Polysaccharides pp 871–890Cite as

Characterization of Psyllium (Plantago ovata) Polysaccharide and Its Uses

Abstract

The Plantago is one of the genera in family Plantaginaceae, a large genus of herbs or sub-herbs distributed mostly in the temperate region and a few in the tropics. Psyllium has been in use as a medicinal agent since ancient times throughout the world. It is used for treatment of constipation, diarrhea, hemorrhoids, and high blood pressure. In olden days it was also used topically to treat skin irritations, such as poison ivy reactions and insect bites and stings. The husk of the seeds of various species of psyllium is used for its medicinal properties. The primary ingredient of the seeds and husk is a mucilaginous polysaccharide. Psyllium has been reported for the treatment of constipation, diarrhea, and irritable bowel syndrome, inflammatory bowel disease (ulcerative colitis), colon cancer, diabetes, and hypercholesterolemia. When mixed with water, the therapeutic efficacy of the drug is due to the swelling of the mucilaginous seed coat which gives bulk and lubrication. Psyllium increases the volume of the feces by absorbing water in the gastrointestinal tract, which stimulates peristalsis. Modification of the polysaccharide by cross-linking or derivatization has been done to investigate its use as pharmaceutical excipient with multifarious roles. Various cross-linkers that have been studied include methacrylamide, N,N-methylenebisacrylamide, and polymethacrylamide.

Keywords

  • Psyllium
  • Ispaghula
  • Dietary fibers
  • Constipation
  • Irritable bowel syndrome
  • Cancer
  • Hyperlipidemia
  • Acrylamides
  • Excipients

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Abbreviations

AAm:

Acrylamide

APS:

Ammonium persulfate

DNA:

Deoxyribonucleic acid

GLUT-4:

Glucose transporter protein

HEMA:

Hydroxylethylmethacrylate

HLA-B2712:

Human leukocyte antigen

IBS:

Irritable bowel syndrome

IP:

Indian Pharmacopoeia

LDL:

Low-density lipoprotein

MAAm:

Methacrylamide

N,NMBAAm:

N,N-methylenebisacrylamide

NVP:

N-vinylpyrrolidone

PAM:

Polyacrylamide

PMA:

Polymethacrylic acid

PVA:

Polyvinyl alcohol

RAPD:

Random amplified polymorphic DNA

SCFA:

Short-chain fatty acids

SHP:

Seed husk of psyllium

References

  • Agrawal SS, Pariddhavi M (2012) Herbal drug technology, 2nd edn. Universities Press, India, pp 715, 721

    Google Scholar 

  • Alternative Medicine Review (2002) volume 7, Number 2 http://www.thorne.com/altmedrev/.fulltext/7/2/155.pdf (cited on 20 April 2014)

  • Anderson JW (1995) Short-chain fatty acids and lipid metabolism: human studies. In: Cummings JH, Rombeau JL, Sakata T (eds) Physiological and clinical aspects of short-chain fatty acids. Cambridge University Press, Cambridge, pp 509–523

    Google Scholar 

  • Anderson JW, Allgood LD, Turner J et al (1999) Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemia. Am J Clin Nutr 70:466–473

    CAS  Google Scholar 

  • Anderson JW, Allgood LD, Lawrence A et al (2000a) Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials. Am J Clin Nutr 71:472–479

    CAS  Google Scholar 

  • Anderson JW, Davidson MH, Blone L et al (2000b) Long-term cholesterol-lowering effects of psyllium as an adjunct to diet therapy in the treatment of hypercholesterolemia. Am J Clin Nutr 71:1433–1438

    CAS  Google Scholar 

  • Anderson JW, Baird P, Davis RH et al (2009) Health benefits of dietary fiber. Nutr Rev 67(4):188–205

    CrossRef  Google Scholar 

  • Andreev PV (2004) Using modified starch in Russian Pharmaceutical Industry. J Pharm Chem 38(8):447–450

    CrossRef  CAS  Google Scholar 

  • Attama AA, Schiche BC, Muller CC (2006) Further characterization of Theobroma oil-beeswax admixtures as lipid matrices for improved drug delivery systems. Eur J Pharm Biopharm 64(3):294–306

    CrossRef  CAS  Google Scholar 

  • Basavaraj SP, Vinayak S, Kulkarni AR (2011) Development and evaluation of psyllium seed husk polysaccharide based wound dressing films. Orient Pharm Exp Med 11:123–129

    CrossRef  Google Scholar 

  • Bell LP, Hectorne K, Reynolds H, Hunninghake DB (1989) Cholesterol-lowering effects of psyllium hydrophilic mucilloid. J Am Med Asso 261:3419–3423

    CrossRef  CAS  Google Scholar 

  • Berg JM (2007) Biochemistry, 6th edn. W.H. Freeman, New York, pp 310–323

    Google Scholar 

  • Bliss DZ, Jung HJ, Savik K et al (2001) Supplementation with dietary fiber improves fecal incontinence. Nurs Res 50:203–213

    CrossRef  CAS  Google Scholar 

  • Bluementhal M et al (1998) Therapeutic guide to herbal medicines. The Complete Commission E Monographs. American Botanical Council, Austin, pp 190–192

    Google Scholar 

  • Bouchoucha MG, Faye A, Savarieau B, Arsac M (2004) Effect of an oral bulking agent and a rectal laxative administered alone or in combination for the treatment of constipation. Gastroenterol Clin Biol 28:438–443

    CrossRef  Google Scholar 

  • Bradley PR (1983) British herbal compendium, vol 1. British Herbal Medicine Association, Bournemouth, pp 199–200

    Google Scholar 

  • British Pharmacopoeia (1968) Published on the recommendation of the Medicines Commission pursuant to the Medicines Act 3rd edn. Medicines Commission, H.M. Stationery Office, Great Britain, pp 34–15

    Google Scholar 

  • Broader JH, Gunn IF, Williams JA (1974) Evaluation of a bulk-forming evacuant in the management of hemorrhoids. Br J Surg 61:142–144

    CrossRef  CAS  Google Scholar 

  • Bruneton J (1995) Pharmacognosy, phytochemistry, medicinal plants. Techniques & documentation, 1st edn. Lavoisier Publishers, Paris, p 915

    Google Scholar 

  • Bruneton J (1999) Pharmacognosy & phytochemistry medicinal plants. Techniques & documentation, vol 81, 2nd edn. Lavoisier Publishers, Paris, pp 106–109

    Google Scholar 

  • Burton R, Manninen V (1982) Influence of a psyllium- based fibre preparation on faecal and serum parameters. Acta Med Scand 668:S91–S94

    Google Scholar 

  • Campbell NA (1996) Biology, 4th edn. Benjamin Cummings, New York, p 23

    Google Scholar 

  • Cheng Y, Ohlsson L, Duan R-D (2004) Psyllium and fat in diets differentially affect the activities and expressions of colonic sphingomyelinases and caspase in mice. Br J Nutr 91:715–723

    CrossRef  CAS  Google Scholar 

  • Degan LP, Phillips SF (1996) How well dose stool form reflects colonic transit? Gut 39:109–113

    CrossRef  Google Scholar 

  • Dietary Reference Intakes for Energy, Carbohydrate, fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients) (2005), Chapter 7: Dietary, Functional and Total fiber. US Department of Agriculture, National Agricultural Library and National Academy of Sciences, Institute of Medicine, Food and Nutrition Board (cited on 15 April 2014)

    Google Scholar 

  • Dietary reference values for carbohydrates and dietary fiber. European Food Safety Authority. (cited on 14 April 2014)

    Google Scholar 

  • Dolz M, Hermandez MJ, Delegido J et al (2007) Influence of xanthum gum and locust bean gum upon flow and thixotropic behaviour of food emulsions containing modified starch. J Food Engg 81(1):179–186

    CrossRef  Google Scholar 

  • Drews L, Kies C, Fox HM (1981) Effect of dietary fiber on copper, zinc, and magnesium utilization by adolescent boys. Am J Clin Nutr 32:1893–1897

    Google Scholar 

  • Duke JA (1985) Handbook of medicinal herbs. CRC Press, Boca Raton, p 209

    Google Scholar 

  • Eastwood M, Kritchevsky D (2005) Dietary fiber: how did we get where we are? Annu Rev Nutr 25:1–8

    CrossRef  CAS  Google Scholar 

  • Etman MA (1995) Effect of a bulk forming laxative on the bioavailability of carbamazepine in man. Drug Dev Ind Pharm 21:1901–1906

    CrossRef  CAS  Google Scholar 

  • Everson GT, Daggy BP, McKinley C, Story JA (1992) Effects of psyllium hydrophilic mucilloid on LDL-cholesterol and bile acid synthesis in hypercholesterolemic men. J Lipid Res 33:1183–1192

    CAS  Google Scholar 

  • Fernandez ML (1995) Distinct mechanisms of plasma LDL lowering by dietary fiber in the guinea pig: specific effects of pectin, guar gum, and psyllium. J Lipid Res 36:2394–2404

    CAS  Google Scholar 

  • Fernandez ML, Ruiz LR, Conde AK et al (1995) Psyllium reduces plasma LDL in guinea pigs by altering hepatic cholesterol homeostasis. J Lipid Res 36:1128–1138

    CAS  Google Scholar 

  • Fernandez BF, Hinojosa J, Sanchez JL et al (1999) Randomized clinical trial of plantago ovata seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colitis. Am J Gastroenterol 94:427–433

    CrossRef  Google Scholar 

  • Fischer M, Nanxiong Y, Gray G et al (2004a) The gel forming polysaccharide of Psyllium husk. Carbohydr Res 4:339

    Google Scholar 

  • Fischer HM, Nanxiong Y, Ralph RGJ, Andersond L, Marletta JA (2004b) The gel forming polysaccharide of psyllium husk (P. ovate Forsk). Carbohydr Res 339:2009–2017

    CrossRef  CAS  Google Scholar 

  • Galvez M, Martin CC, Lopez LM, Cortes F, Ayuso MJ (2003) Cytotoxic effect of Plantago spp. on cancer cell lines. J Ethnopharma 88:125–130

    CrossRef  CAS  Google Scholar 

  • Ganji V, Kies CV (1994) Psyllium husk fibre supplementation to soybean and coconut oil diets of humans: effect on fat digestibility and faecal fatty acid excretion. Eur J Clin Nutr 48:595–597

    CAS  Google Scholar 

  • Gattuso JM, Kamm MA (1994) Adverse effects of drugs used in the management of constipation and diarrhea. Drug Saf 10:47–65

    CrossRef  CAS  Google Scholar 

  • George M, Abraham TE (2007) pH sensitive alginate-guar gum hydrogel for the controlled delivery of protein drugs. Int J Pharm 335(1–2):123–129

    CrossRef  CAS  Google Scholar 

  • Gepts P (1993) The use of molecular and biochemical markers in crop-evolution studies. In: Hecht MK (ed) Evolutionary biology. Plenum Press, New York, pp 51–94

    CrossRef  Google Scholar 

  • Gholardi E, Tavant A, Celandroni F et al (2000) Effect of a novel mucoadhesive polysaccharide obtained from tamarind seeds on the intraocular penetration of Gentamicin and Ofloxacin in rabbits. J Antimicrob Chemother 46:831–834

    CrossRef  Google Scholar 

  • Gupta AK (2005) Handbook on herbs: cultivation & processing. Asia Pacific Business Press Inc, Delhi, pp 329–330

    Google Scholar 

  • Hänsel R et al (1994a) Hagers Handbuch der Pharmazeutischen Praxis, vol 6, 5th edn. Springer, Berlin, pp 361–384

    CrossRef  Google Scholar 

  • Hänsel R, Keller K, Pimpler H, Schneider G (1994b) Plantago. In: Drogen P-Z (ed) Hagers handbuch der Pharmazeutischen Praxis, vol 6, 5th edn. Springer, Berlin, pp 221–239

    CrossRef  Google Scholar 

  • Hartwell JL (1982) Plants used against cancer: a survey. Quarterman Publications, Lawrence (cited on 16 May 2014)

    Google Scholar 

  • Horton JD, Cuthbert JA, Spady DK (1994) Regulation of hepatic 7 alpha-hydroxylase expression by dietary psyllium in the hamster. J Clin Invest 93:2084–2092

    CrossRef  CAS  Google Scholar 

  • http://phytosanitorysolution.com/ (cited on 15 April 2014)

  • http://savoursomepsyllium.blogspot.in/2010/11/historytraditional-use.html (cited on 15 Apr 2014)

  • http://www.psylliums.com/psyllium.htm (cited on 15 Apr 2014)

  • Indian Pharmacopoeia (2010) Government of India, Ministry of Health & Family Welfare, Published by the Indian Pharmacopoeia Commission, vol 3, pp 2153

    Google Scholar 

  • Jenkins DJA, Jenkins AL, Wolever T, Vuksan V (1990) Fiber and physiological and potentially therapeutic effects of slowing carbohydrate absorption. In: Furda I, Brine CJ (eds) New developments in dietary fiber. Plenum Press, New York, pp 129–134

    CrossRef  Google Scholar 

  • Jones PJ, Varady KA (2008) Are functional foods redefining nutritional requirements? Appl Physiol Nutr Metab 33(1):118–123

    CrossRef  CAS  Google Scholar 

  • Khourefieh HA, Herald TJ, Aramouni F, Alavi S (2007) Intrinsic viscosity and viscoelastic properties of xanthan/guar mixtures in dilute solutions. Food Res Int 40(7):883–893

    CrossRef  Google Scholar 

  • Koch A, Voderholzer WA, Klauser AG, Muller LS (1997) Symptoms in chronic constipation. Dis Colon Return 40:902–906

    CrossRef  CAS  Google Scholar 

  • Kulkarni GT, Gowtharnarajan K et al (2005) Development of controlled release spheroids using natural polysaccharides as a release modifier. Drug Deliv 12(4):201–206

    CrossRef  CAS  Google Scholar 

  • Kumar R, Sharma K (2013) Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems. Front Chem Sci Eng 7(1):116–122

    CrossRef  CAS  Google Scholar 

  • Kumar A, Kumar N, Vij JC, Sarin SK, Anand BS (1987) Optimal dosage of ispaghula husk in patients with irritable bowel syndrome: correlation of symptom relief with whole gut transit time and stool weight. Gut 28:150–155

    CrossRef  CAS  Google Scholar 

  • Levin EG, Miller VT, Muesing RA et al (1990) Comparison of psyllium hydrophilic mucilloid and cellulose as adjuncts to a prudent diet in the treatment of mild to moderate hypercholesterolemia. Arch Intern Med 150:1822–1827

    CrossRef  CAS  Google Scholar 

  • Liangli Yu, Zhuohong Xie and Wei Liu (2012) Nutraceutical and health properties of psyllium. In: Liangli L Yu, Rong Tsao, Fereidoon Shahidi (eds) Cereals and pulses: nutraceutical properties and health benefits. Wiley. doi:10.1002/9781118229415.ch11) (cited on 18 May 2014)

    Google Scholar 

  • Majmudar H, Mourya V, Devdhe S, Chandak R (2008) Pharmaceutical applications of ispaghula husk: mucilage. Int J Pharm Sci Rev Res 18(1):49–55

    Google Scholar 

  • Marteau P et al (1994) Digestibility and bulking effect of ispaghula husks in healthy humans. Gut 35:1747–1752

    CrossRef  CAS  Google Scholar 

  • Matheson HB, Colon IS, Story JA (1995) Cholesterol 7 alpha-hydroxylase activity is increased by dietary modification with psyllium hydrocolloid, pectin, cholesterol and cholestyramine in rats. J Nutr 125:454–458

    CAS  Google Scholar 

  • Miyazaki S, Suisha F, Kawasaki N et al (1998) Thermally reversible xyloglucan gels as a vehicle for rectal delivery. J Cont Release 56(1–3):75–83

    CrossRef  CAS  Google Scholar 

  • New HMPC Commission, (Herbal Medicinal Products Committee) The European Scientific Cooperative on Phytotherapy (ESCOP), WHO vol 1 (cited on 18 May 2014).

    Google Scholar 

  • Nordgaard I, Hove H, Clausen MR, Mortensen PB (1996) Colonic production of butyrate in patients with previous colonic cancer during long-term treatment with dietary fibre (Plantago ovate seeds). Scand J Gastroenterol 31:1011–1020

    CrossRef  CAS  Google Scholar 

  • Olson BH, Anderson SM, Becker MP et al (1997) Psyllium-enriched cereals lower blood total cholesterol and LDL cholesterol, but not HDL cholesterol, in hypercholesterolemic adults: results of a meta-analysis. J Nutr 127:1973–1980

    CAS  Google Scholar 

  • Pal MD, Raychoudhuri SS (2004) Estimation in genetic variability in Plantago ovata cultivars. Biol Plant 47:459–462

    CrossRef  Google Scholar 

  • Park HS, Lee JY, Cho SH et al (2002) Colon delivery of prednisolone based on chitosan coated polysaccharide tablets. Arch Pharma Res 25(6):964–968

    CrossRef  CAS  Google Scholar 

  • Pearlman BB (1990) Interaction between lithium salts and ispaghula husks. Lancet 335:416

    CrossRef  Google Scholar 

  • Perez MM, Gomez CA, Colombo LT et al (1996) Effect of fiber supplements on internal bleeding hemorrhoids. Hepatogastroenterology 43:1504–1507

    Google Scholar 

  • Qvitzau S, Matzen P, Madsen P (1988) Treatment of chronic diarrhoea: loperamide versus ispaghula husk and calcium. Scand J Gastroenterol 23:1237–1240

    CrossRef  CAS  Google Scholar 

  • Rangari VD (2008) Pharmacognosy & phytochemistry, vol 1, 2nd edn. Career Publications, India, pp 202–204

    Google Scholar 

  • Raychaudhuri SS, Pramanik S (1997) Comparative studies on DNA content and superoxide dismutase isozymes of Plantago ovata, P. psyllium, P. indica, P. lanceolata. J Med Arom Plant Sci 19:964–967

    Google Scholar 

  • Read NW (1986) Dietary fiber and bowel transit. In: Vahouny GV, Kritchevsky D (eds) Dietary fiber basic and clinical aspects. Plenum Press, New York, pp 91–100

    Google Scholar 

  • Reynolds M (1993) The extra pharmacopeia, 30th edn. The Pharmaceutical Press, London, p 900

    Google Scholar 

  • Romero AL, Romero JE, Galviz S, Fernandez ML (1998) Cookies enriched with psyllium or oat bran lower plasma LDL cholesterol in normal and hypercholesterolemic men from Northern Mexico. J Am Coll Nutr 17:601–608

    CrossRef  CAS  Google Scholar 

  • Sakkinen M, Linna A, Ojala S et al (2003) In vivo evaluation of matrix granules containing microcrystalline chitosan as a gel forming excipients. Int J Pharm 250(1):227–237

    CrossRef  CAS  Google Scholar 

  • Samantaray S, Dhagat U, Maiti S (2010) Evaluation of genetic relationships in Plantago species using random amplified polymorphic DNA (RAPD) markers. Plant Biotechnol 27:297–303

    CrossRef  CAS  Google Scholar 

  • Sen G, Mishra S, Usha Rani G, Rani P, Prasad R (2010) Microwave initiated synthesis of polyacrylamide grafted psyllium and its application as a flocculant. Int J Biol Macromol 50:369–375

    CrossRef  Google Scholar 

  • Singh B, Chauhan N, Kumar S, Bala R (2008) Psyllium and copolymers of 2-hydroxylethylmethacrylate and acrylamide-based novel devices for the use in colon specific antibiotic drug delivery. Int J Pharm 352:74–80

    CrossRef  CAS  Google Scholar 

  • Singh B, Kumar S (2008) Synthesis and characterization of psyllium-NVP based drug delivery system through radiation crosslinking polymerization. Nucl Inst Methods Phys Res 266:3417–3430

    CrossRef  CAS  Google Scholar 

  • Singh B, Chauhan N (2010) Dietary fiber psyllium based hydrogels for use in insulin delivery. Int J Diabetes Mellitus 2:32–37

    CrossRef  CAS  Google Scholar 

  • Singh B, Sharma V (2010) Design of psyllium–PVA–acrylic acid based novel hydrogels for use in antibiotic drug delivery. Int J Pharm 389:94–106

    CrossRef  CAS  Google Scholar 

  • Sölter H, Lorenz D (1983) Summary of clinical results with prodiem plain, a bowel regulating agent. Today’s Ther Trends 1:45–59

    Google Scholar 

  • Sprecher DL, Harris BV, Goldberg AC et al (1993) Efficacy of psyllium in reducing serum cholesterol levels in hypercholesterolemic patients on high- or low-fat diets. Ann Intern Med 119:545–554

    CrossRef  CAS  Google Scholar 

  • Stewart RB, Hale WE, Moore MT et al (1991) Effect of psyllium hydrophilic mucilloid on serum cholesterol in the elderly. Dig Dis Sci 36:329–334

    CrossRef  CAS  Google Scholar 

  • Sumath S, Ray AR (2002) Release behaviour of drugs from tamarind seeds polysaccharides tablets. J Pharm Sci 5(1):12–18

    Google Scholar 

  • Terpstra AH, Lapre JA, de Vries HT, Beynen AC (2000) Hypocholesterolemic effect of dietary psyllium in female rats. Ann Nutr Metab 44:223–228

    CrossRef  CAS  Google Scholar 

  • Thanou M, Verhoef JC, Marbach P (2000) Intestinal absorption of octreotide: N-trimethyl chitosan chloride ameliorates the permeability and absorption properties of the somatostatin analogue in vitro and in vivo. J Pharm Sci 89(7):951–957

    CrossRef  CAS  Google Scholar 

  • Trease GE, Evans WC (2008) A textbook of pharmacognosy, Indian edn, 16th edn. W B Saunders, Noida, pp 168, 215, 193

    Google Scholar 

  • Truestar Health: http://www.truestarhealth.com/Notes/2150006.html#Traditional-Use (cited on 15 April 2014)

  • Trivedi PC (2004) Medicinal plants utilisation & conservation. Avishkar Publishers & Distributors, Jaipur, pp 121–129

    Google Scholar 

  • Turley SD, Daggy BP, Dietschy JM (1994) Psyllium augments the cholesterol-lowering action of cholestyramine in hamsters by enhancing sterol loss from the liver. Gastroenterology 107:444–452

    CAS  Google Scholar 

  • Turnbull WH, Thomas HG (1995) The effect of Plantago ovata seed containing preparation on appetite variables, nutrient and energy intake. Int J Obes Relat Metab Disord 19:338–342

    CAS  Google Scholar 

  • Tyler VE, Brady LR, Robbers JE (1988) Pharmacognosy, 9th edn. Lea & Febiger, Philadelphia, pp 52–53

    Google Scholar 

  • United States Pharmacopoeia (2006) The official compendia of standards. Asian Edition, National Formulary, pp 1863, 1864

    Google Scholar 

  • Vahabi AA, Lotif A, Solouki M, Bahrami S (2008) Molecular and morphological markers for the evaluation of diversity between Plantago ovata in Iran. Biotechnology 7:702–709

    CrossRef  CAS  Google Scholar 

  • Vega-Lopez S, Vidal-Quintanar RL, Fernandez ML (2001) Sex and hormonal status influence plasma lipid responses to psyllium. Am J Clin Nutr 74:435–441

    CAS  Google Scholar 

  • Voderholzer WA, Schatke W, Muhldorfer BE et al (1997) Clinical response to dietary fiber treatment of chronic constipation. Am J Gastroenterol 92:95–98

    CAS  Google Scholar 

  • Webster DJ, Pugh DC, Craven JL (1978) The use of bulk evacuant in patients with hemorrhoids. Br J Surg 65:291–292

    CrossRef  CAS  Google Scholar 

  • Weickert MO, Pfeiffer AF (2008) Metabolic effects of dietary fiber and any other substance that consume and prevention of diabetes. J Nutr 138(3):439–442

    CAS  Google Scholar 

  • Whitkus R, Doebley J, Wendel JF (1994) Nuclear DNA markers in systematics and evolution. In: Phillips L, Vasil IK (eds) DNA based markers in plants. Kluwer Academic Publishers, Dordrecht, pp 116–141

    CrossRef  Google Scholar 

  • Wolff K, Morgan-Richards M, Davison AW (2000) Patterns of molecular genetic variation in Plantago major and P. intermedia in relation to ozone resistance. New Phytol 145:501–509

    CrossRef  CAS  Google Scholar 

  • Yu LL, Lutterodt H, Cheng Z (2009) Beneficial health properties of psyllium and approaches to improve its functionalities. Adv Food Nutr Res 55:193–220. doi:10.1016/s1043-4526(08)00404-x (cited on 18 May 2014)

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmaceutics, AISSMS College of Pharmacy, Kennedy Road, Near RTO, Pune, 411 001, India

    Ashwini R. Madgulkar, Monica R. P. Rao & Deepa Warrier

Authors
  1. Ashwini R. Madgulkar
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  2. Monica R. P. Rao
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  3. Deepa Warrier
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Correspondence to Monica R. P. Rao .

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Editors and Affiliations

  1. Botany Department, M.L.Sukhadia University, Udaipur, India

    Kishan Gopal Ramawat

  2. Groupe d’Etude des Substances Végétales à Activité Biologique, Université de Bordeaux, Institut des Sciences de la Vigne et du Vin, Villenave d'Ornon, France

    Jean-Michel Mérillon

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Madgulkar, A.R., Rao, M.R.P., Warrier, D. (2015). Characterization of Psyllium (Plantago ovata) Polysaccharide and Its Uses. In: Ramawat, K., Mérillon, JM. (eds) Polysaccharides. Springer, Cham. https://doi.org/10.1007/978-3-319-16298-0_49

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