Reference Work Entry


pp 1555-1582


Chemically Modified Natural Polysaccharides to Form Gels

  • John GarnerAffiliated withAkina, Inc.
  • , Kinam ParkAffiliated withDepartments of Biomedical Engineering and Pharmaceutics, Weldon School of Biomedical Engineering, Purdue University Email author 


Polysaccharides have been utilized for a wide variety of industrial, cosmetic, food, and medical applications. The presence of functional groups on polysaccharides has been exploited for chemical modification to prepare polymers with unique properties. Various polysaccharides form hydrogels through physical or chemical cross-linking, and many of them possess environmentally responsive properties, known as smart hydrogels. Polysaccharide-based smart hydrogels are ideal for biomedical and pharmaceutical applications due to their inherent biocompatibility, degradability, and environment sensitivity, such as pH, temperature, and specific biomolecules.


Polysaccharides Chemical modification “Smart” hydrogels Chemically cross-linked Physically cross-linked