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Principles of Energy Homeostasis

Metabolic Syndrome

Abstract

Mammals have evolved complex mechanisms to obtain energy from food; store excess energy in the forms of glycogen, fat, and protein; and utilize energy efficiently for vital functions. Obesity develops when energy intake exceeds energy expenditure. While obesity treatment is mostly focused on reducing food intake, studies suggest that increasing energy expenditure through physical activity and adaptive thermogenesis is an important strategy for weight loss and maintenance of health. This chapter will describe fundamental concepts of bioenergetics and provide a framework for understanding the pathogenesis and treatment of metabolic syndrome.

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References

  • Ahima RS (2011) Digging deeper into obesity. The Journal of clinical investigation 121 (6):2076–2079. doi:10.1172/JCI58719

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Amatruda JM, Statt MC, Welle SL (1993) Total and resting energy expenditure in obese women reduced to ideal body weight. The Journal of clinical investigation 92 (3):1236–1242. doi:10.1172/JCI116695

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Astrup A (1986) Thermogenesis in human brown adipose tissue and skeletal muscle induced by sympathomimetic stimulation. Acta endocrinologica Supplementum 278:1–32

    CAS  PubMed  Google Scholar 

  • Astrup A, Bulow J, Madsen J, Christensen NJ (1985) Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man. The American journal of physiology 248 (5 Pt 1):E507-515

    CAS  PubMed  Google Scholar 

  • Astrup A, Gotzsche PC, van de Werken K, Ranneries C, Toubro S, Raben A, Buemann B (1999) Meta-analysis of resting metabolic rate in formerly obese subjects. The American journal of clinical nutrition 69 (6):1117–1122

    CAS  PubMed  Google Scholar 

  • Baba S, Tatsumi M, Ishimori T, Lilien DL, Engles JM, Wahl RL (2007) Effect of nicotine and ephedrine on the accumulation of 18F-FDG in brown adipose tissue. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 48 (6):981–986. doi:10.2967/jnumed.106.039065

    Article  CAS  Google Scholar 

  • Bal NC, Maurya SK, Sopariwala DH, Sahoo SK, Gupta SC, Shaikh SA, Pant M, Rowland LA, Bombardier E, Goonasekera SA, Tupling AR, Molkentin JD, Periasamy M (2012) Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. Nature medicine 18 (10):1575–1579. doi:10.1038/nm.2897

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Batsis JA, Mackenzie TA, Barre LK, Lopez-Jimenez F, Bartels SJ (2014) Sarcopenia, sarcopenic obesity and mortality in older adults: results from the National Health and Nutrition Examination Survey III. European journal of clinical nutrition 68 (9):1001–1007. doi:10.1038/ejcn.2014.117

    Article  CAS  PubMed  Google Scholar 

  • Bogardus C, Lillioja S, Ravussin E, Abbott W, Zawadzki JK, Young A, Knowler WC, Jacobowitz R, Moll PP (1986) Familial dependence of the resting metabolic rate. The New England journal of medicine 315 (2):96–100. doi:10.1056/NEJM198607103150205

    Article  CAS  PubMed  Google Scholar 

  • Bosy-Westphal A, Eichhorn C, Kutzner D, Illner K, Heller M, Muller MJ (2003) The age-related decline in resting energy expenditure in humans is due to the loss of fat-free mass and to alterations in its metabolically active components. The Journal of nutrition 133 (7):2356–2362

    CAS  PubMed  Google Scholar 

  • Bosy-Westphal A, Reinecke U, Schlorke T, Illner K, Kutzner D, Heller M, Muller MJ (2004) Effect of organ and tissue masses on resting energy expenditure in underweight, normal weight and obese adults. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 28 (1):72–79. doi:10.1038/sj.ijo.0802526

    Article  CAS  Google Scholar 

  • Bouchard C, Tremblay A, Despres JP, Nadeau A, Lupien PJ, Theriault G, Dussault J, Moorjani S, Pinault S, Fournier G (1990) The response to long-term overfeeding in identical twins. The New England journal of medicine 322 (21):1477–1482. doi:10.1056/NEJM199005243222101

    Article  CAS  PubMed  Google Scholar 

  • Bouchard C, Tremblay A, Nadeau A, Despres JP, Theriault G, Boulay MR, Lortie G, Leblanc C, Fournier G (1989) Genetic effect in resting and exercise metabolic rates. Metabolism: clinical and experimental 38 (4):364–370

    Article  CAS  Google Scholar 

  • Brundin T, Thorne A, Wahren J (1992) Heat leakage across the abdominal wall and meal-induced thermogenesis in normal-weight and obese subjects. Metabolism: clinical and experimental 41 (1):49–55

    Article  CAS  Google Scholar 

  • Caleyachetty R, Echouffo-Tcheugui JB, Tait CA, Schilsky S, Forrester T, Kengne AP (2015) Prevalence of behavioural risk factors for cardiovascular disease in adolescents in low-income and middle-income countries: an individual participant data meta-analysis. The lancet Diabetes & endocrinology. doi:10.1016/S2213-8587(15)00076-5

    Google Scholar 

  • Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR (2009) Identification and importance of brown adipose tissue in adult humans. The New England journal of medicine 360 (15):1509–1517. doi:10.1056/NEJMoa0810780

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Eckel RH, Kahn SE, Ferrannini E, Goldfine AB, Nathan DM, Schwartz MW, Smith RJ, Smith SR (2011) Obesity and type 2 diabetes: what can be unified and what needs to be individualized? The Journal of clinical endocrinology and metabolism 96 (6):1654–1663. doi:10.1210/jc.2011-0585

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Elia M, Cummings JH (2007) Physiological aspects of energy metabolism and gastrointestinal effects of carbohydrates. European journal of clinical nutrition 61 Suppl 1:S40-74. doi:10.1038/sj.ejcn.1602938

    Article  CAS  PubMed  Google Scholar 

  • Enerback S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper ME, Kozak LP (1997) Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387 (6628):90–94. doi:10.1038/387090a0

    Article  CAS  PubMed  Google Scholar 

  • Feldmann HM, Golozoubova V, Cannon B, Nedergaard J (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell metabolism 9 (2):203–209. doi:10.1016/j.cmet.2008.12.014

    Article  CAS  PubMed  Google Scholar 

  • Flatt JP, Ravussin E, Acheson KJ, Jequier E (1985) Effects of dietary fat on postprandial substrate oxidation and on carbohydrate and fat balances. The Journal of clinical investigation 76 (3):1019–1024. doi:10.1172/JCI112054

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Frayn KN (2002) Adipose tissue as a buffer for daily lipid flux. Diabetologia 45 (9):1201–1210. doi:10.1007/s00125-002-0873-y

    Article  CAS  PubMed  Google Scholar 

  • Golozoubova V, Hohtola E, Matthias A, Jacobsson A, Cannon B, Nedergaard J (2001) Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 15 (11):2048–2050. doi:10.1096/fj.00-0536fje

    CAS  Google Scholar 

  • Green DE, Zande HD (1981) Universal energy principle of biological systems and the unity of bioenergetics. Proceedings of the National Academy of Sciences of the United States of America 78 (9):5344–5347

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Harms M, Seale P (2013) Brown and beige fat: development, function and therapeutic potential. Nature medicine 19 (10):1252–1263. doi:10.1038/nm.3361

    Article  CAS  PubMed  Google Scholar 

  • Harper ME, Green K, Brand MD (2008) The efficiency of cellular energy transduction and its implications for obesity. Annual review of nutrition 28:13–33. doi:10.1146/annurev.nutr.28.061807.155357

    Article  CAS  PubMed  Google Scholar 

  • Hill JO, Peters JC, Reed GW, Schlundt DG, Sharp T, Greene HL (1991) Nutrient balance in humans: effects of diet composition. The American journal of clinical nutrition 54 (1):10–17

    CAS  PubMed  Google Scholar 

  • Hill JO, Wyatt HR, Peters JC (2012) Energy balance and obesity. Circulation 126 (1):126–132. doi:10.1161/CIRCULATIONAHA.111.087213

    Article  PubMed Central  PubMed  Google Scholar 

  • Human energy requirements: report of a joint FAO/WHO/UNU Expert Consultation (2005). Food and nutrition bulletin 26 (1):166

    Google Scholar 

  • Jequier E, Acheson K, Schutz Y (1987) Assessment of energy expenditure and fuel utilization in man. Annual review of nutrition 7:187–208. doi:10.1146/annurev.nu.07.070187.001155

    Article  CAS  PubMed  Google Scholar 

  • Johannsen DL, Ravussin E (2008) Spontaneous physical activity: relationship between fidgeting and body weight control. Current opinion in endocrinology, diabetes, and obesity 15 (5):409–415. doi:10.1097/MED.0b013e32830b10bb

    Article  PubMed  Google Scholar 

  • Johnstone AM, Murison SD, Duncan JS, Rance KA, Speakman JR (2005) Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine. The American journal of clinical nutrition 82 (5):941–948

    CAS  PubMed  Google Scholar 

  • Joint WHOFAOUNUEC (2007) Protein and amino acid requirements in human nutrition. World Health Organization technical report series (935):1–265

    Google Scholar 

  • Keys A, Taylor HL, Grande F (1973) Basal metabolism and age of adult man. Metabolism: clinical and experimental 22 (4):579–587

    Article  CAS  Google Scholar 

  • Kim TN, Choi KM (2015) The implications of sarcopenia and sarcopenic obesity on cardiometabolic disease. Journal of cellular biochemistry 116 (7):1171–1178. doi:10.1002/jcb.25077

    Article  CAS  PubMed  Google Scholar 

  • Kontani Y, Wang Y, Kimura K, Inokuma KI, Saito M, Suzuki-Miura T, Wang Z, Sato Y, Mori N, Yamashita H (2005) UCP1 deficiency increases susceptibility to diet-induced obesity with age. Aging cell 4 (3):147–155. doi:10.1111/j.1474-9726.2005.00157.x

    Article  CAS  PubMed  Google Scholar 

  • Kopecky J, Clarke G, Enerback S, Spiegelman B, Kozak LP (1995) Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. The Journal of clinical investigation 96 (6):2914–2923. doi:10.1172/JCI118363

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Kummitha CM, Kalhan SC, Saidel GM, Lai N. Physiol Rep. 2014 Sep 28;2(9). pii: e121590

    Google Scholar 

  • Larson DE, Ferraro RT, Robertson DS, Ravussin E (1995) Energy metabolism in weight-stable postobese individuals. The American journal of clinical nutrition 62 (4):735–739

    CAS  PubMed  Google Scholar 

  • Leibel RL, Rosenbaum M, Hirsch J (1995) Changes in energy expenditure resulting from altered body weight. The New England journal of medicine 332 (10):621–628. doi:10.1056/NEJM199503093321001

    Article  CAS  PubMed  Google Scholar 

  • Levine JA, Eberhardt NL, Jensen MD (1999) Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science 283 (5399):212–214

    Article  CAS  PubMed  Google Scholar 

  • Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM (2002) Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 418 (6899):797–801. doi:10.1038/nature00904

    Article  CAS  PubMed  Google Scholar 

  • Livesey G, Elia M (1988) Estimation of energy expenditure, net carbohydrate utilization, and net fat oxidation and synthesis by indirect calorimetry: evaluation of errors with special reference to the detailed composition of fuels. The American journal of clinical nutrition 47 (4):608–628

    CAS  PubMed  Google Scholar 

  • Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, Fall T, Ferreira T, Gustafsson S, Kutalik Z, Luan J, Magi R, Randall JC, Winkler TW, Wood AR, Workalemahu T, Faul JD, Smith JA, Hua Zhao J, Zhao W, Chen J, Fehrmann R, Hedman AK, Karjalainen J, Schmidt EM, Absher D, Amin N, Anderson D, Beekman M, Bolton JL, Bragg-Gresham JL, Buyske S, Demirkan A, Deng G, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Goel A, Gong J, Jackson AU, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Mangino M, Mateo Leach I, Medina-Gomez C, Medland SE, Nalls MA, Palmer CD, Pasko D, Pechlivanis S, Peters MJ, Prokopenko I, Shungin D, Stancakova A, Strawbridge RJ, Ju Sung Y, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Isaacs A, Albrecht E, Arnlov J, Arscott GM, Attwood AP, Bandinelli S, Barrett A, Bas IN, Bellis C, Bennett AJ, Berne C, Blagieva R, Bluher M, Bohringer S, Bonnycastle LL, Bottcher Y, Boyd HA, Bruinenberg M, Caspersen IH, Ida Chen YD, Clarke R, Daw EW, de Craen AJ, Delgado G, Dimitriou M, Doney AS, Eklund N, Estrada K, Eury E, Folkersen L, Fraser RM, Garcia ME, Geller F, Giedraitis V, Gigante B, Go AS, Golay A, Goodall AH, Gordon SD, Gorski M, Grabe HJ, Grallert H, Grammer TB, Grassler J, Gronberg H, Groves CJ, Gusto G, Haessler J, Hall P, Haller T, Hallmans G, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hengstenberg C, Holmen O, Hottenga JJ, James AL, Jeff JM, Johansson A, Jolley J, Juliusdottir T, Kinnunen L, Koenig W, Koskenvuo M, Kratzer W, Laitinen J, Lamina C, Leander K, Lee NR, Lichtner P, Lind L, Lindstrom J, Sin Lo K, Lobbens S, Lorbeer R, Lu Y, Mach F, Magnusson PK, Mahajan A, McArdle WL, McLachlan S, Menni C, Merger S, Mihailov E, Milani L, Moayyeri A, Monda KL, Morken MA, Mulas A, Muller G, Muller-Nurasyid M, Musk AW, Nagaraja R, Nothen MM, Nolte IM, Pilz S, Rayner NW, Renstrom F, Rettig R, Ried JS, Ripke S, Robertson NR, Rose LM, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Scott WR, Seufferlein T, Shi J, Vernon Smith A, Smolonska J, Stanton AV, Steinthorsdottir V, Stirrups K, Stringham HM, Sundstrom J, Swertz MA, Swift AJ, Syvanen AC, Tan ST, Tayo BO, Thorand B, Thorleifsson G, Tyrer JP, Uh HW, Vandenput L, Verhulst FC, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Warren HR, Waterworth D, Weedon MN, Wilkens LR, Willenborg C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q, LifeLines Cohort S, Brennan EP, Choi M, Dastani Z, Drong AW, Eriksson P, Franco-Cereceda A, Gadin JR, Gharavi AG, Goddard ME, Handsaker RE, Huang J, Karpe F, Kathiresan S, Keildson S, Kiryluk K, Kubo M, Lee JY, Liang L, Lifton RP, Ma B, McCarroll SA, McKnight AJ, Min JL, Moffatt MF, Montgomery GW, Murabito JM, Nicholson G, Nyholt DR, Okada Y, Perry JR, Dorajoo R, Reinmaa E, Salem RM, Sandholm N, Scott RA, Stolk L, Takahashi A, Tanaka T, Van't Hooft FM, Vinkhuyzen AA, Westra HJ, Zheng W, Zondervan KT, Consortium AD, Group A-BW, Consortium CAD, Consortium CK, Glgc, Icbp, Investigators M, Mu TC, Consortium MI, Consortium P, ReproGen C, Consortium G, International Endogene C, Heath AC, Arveiler D, Bakker SJ, Beilby J, Bergman RN, Blangero J, Bovet P, Campbell H, Caulfield MJ, Cesana G, Chakravarti A, Chasman DI, Chines PS, Collins FS, Crawford DC, Cupples LA, Cusi D, Danesh J, de Faire U, den Ruijter HM, Dominiczak AF, Erbel R, Erdmann J, Eriksson JG, Farrall M, Felix SB, Ferrannini E, Ferrieres J, Ford I, Forouhi NG, Forrester T, Franco OH, Gansevoort RT, Gejman PV, Gieger C, Gottesman O, Gudnason V, Gyllensten U, Hall AS, Harris TB, Hattersley AT, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Homuth G, Hovingh GK, Humphries SE, Hunt SC, Hypponen E, Illig T, Jacobs KB, Jarvelin MR, Jockel KH, Johansen B, Jousilahti P, Jukema JW, Jula AM, Kaprio J, Kastelein JJ, Keinanen-Kiukaanniemi SM, Kiemeney LA, Knekt P, Kooner JS, Kooperberg C, Kovacs P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimaki T, Lyssenko V, Mannisto S, Marette A, Matise TC, McKenzie CA, McKnight B, Moll FL, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Madden PA, Pasterkamp G, Peden JF, Peters A, Postma DS, Pramstaller PP, Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ridker PM, Rioux JD, Ritchie MD, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schunkert H, Schwarz PE, Sever P, Shuldiner AR, Sinisalo J, Stolk RP, Strauch K, Tonjes A, Tregouet DA, Tremblay A, Tremoli E, Virtamo J, Vohl MC, Volker U, Waeber G, Willemsen G, Witteman JC, Zillikens MC, Adair LS, Amouyel P, Asselbergs FW, Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bornstein SR, Bottinger EP, Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PI, Dedoussis G, Ferrucci L, Franks PW, Froguel P, Groop LC, Haiman CA, Hamsten A, Hui J, Hunter DJ, Hveem K, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin NG, Marz W, Melbye M, Metspalu A, Moebus S, Munroe PB, Njolstad I, Oostra BA, Palmer CN, Pedersen NL, Perola M, Perusse L, Peters U, Power C, Quertermous T, Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sattar N, Schadt EE, Schlessinger D, Slagboom PE, Snieder H, Spector TD, Thorsteinsdottir U, Stumvoll M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Weir DR, Wichmann HE, Wilson JF, Zanen P, Borecki IB, Deloukas P, Fox CS, Heid IM, O'Connell JR, Strachan DP, Stefansson K, van Duijn CM, Abecasis GR, Franke L, Frayling TM, McCarthy MI, Visscher PM, Scherag A, Willer CJ, Boehnke M, Mohlke KL, Lindgren CM, Beckmann JS, Barroso I, North KE, Ingelsson E, Hirschhorn JN, Loos RJ, Speliotes EK (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature 518 (7538):197–206. doi:10.1038/nature14177

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Loos RJ, Bouchard C (2008) FTO: the first gene contributing to common forms of human obesity. Obesity reviews : an official journal of the International Association for the Study of Obesity 9 (3):246–250. doi:10.1111/j.1467-789X.2008.00481.x

    Article  CAS  Google Scholar 

  • Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI, Prostate LC, Ovarian Cancer Screening T, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM, Kora, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L, Nurses' Health S, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK, Diabetes Genetics I, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M, Sardi NIAS, Vogel CI, Wallace C, Waterworth DM, Weedon MN, Wellcome Trust Case Control C, Willer CJ, Fusion, Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I, Jacobs KB, Chanock SJ, Hayes RB, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Lyon HN, Voight BF, Ridderstrale M, Groop L, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature genetics 40 (6):768–775. doi:10.1038/ng.140

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Maurya SK, Bal NC, Sopariwala DH, Pant M, Rowland LA, Shaikh SA, Periasamy M (2015) Sarcolipin Is a Key Determinant of the Basal Metabolic Rate, and Its Overexpression Enhances Energy Expenditure and Resistance against Diet-induced Obesity. The Journal of biological chemistry 290 (17):10840–10849. doi:10.1074/jbc.M115.636878

    Article  CAS  PubMed  Google Scholar 

  • Plasqui G, Bonomi AG, Westerterp KR (2013) Daily physical activity assessment with accelerometers: new insights and validation studies. Obesity reviews : an official journal of the International Association for the Study of Obesity 14 (6):451–462. doi:10.1111/obr.12021

    Article  CAS  Google Scholar 

  • Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92 (6):829–839

    Article  CAS  PubMed  Google Scholar 

  • Ravussin E, Harper IT, Rising R, Bogardus C (1991) Energy expenditure by doubly labeled water: validation in lean and obese subjects. The American journal of physiology 261 (3 Pt 1):E402-409

    CAS  PubMed  Google Scholar 

  • Ravussin E, Lillioja S, Anderson TE, Christin L, Bogardus C (1986) Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. The Journal of clinical investigation 78 (6):1568–1578. doi:10.1172/JCI112749

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Ravussin E, Lillioja S, Knowler WC, Christin L, Freymond D, Abbott WG, Boyce V, Howard BV, Bogardus C (1988) Reduced rate of energy expenditure as a risk factor for body-weight gain. The New England journal of medicine 318 (8):467–472. doi:10.1056/NEJM198802253180802

    Article  CAS  PubMed  Google Scholar 

  • Redman LM, Heilbronn LK, Martin CK, de Jonge L, Williamson DA, Delany JP, Ravussin E, Pennington CT (2009) Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss. PloS one 4 (2):e4377. doi:10.1371/journal.pone.0004377

    Article  PubMed Central  PubMed  Google Scholar 

  • Rising R, Keys A, Ravussin E, Bogardus C (1992) Concomitant interindividual variation in body temperature and metabolic rate. The American journal of physiology 263 (4 Pt 1):E730-734

    CAS  PubMed  Google Scholar 

  • Rolfe DF, Brown GC (1997) Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiological reviews 77 (3):731–758

    CAS  PubMed  Google Scholar 

  • Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S, Gallagher D, Mayer L, Murphy E, Leibel RL (2005) Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. The Journal of clinical investigation 115 (12):3579–3586. doi:10.1172/JCI25977

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Saad MF, Alger SA, Zurlo F, Young JB, Bogardus C, Ravussin E (1991) Ethnic differences in sympathetic nervous system-mediated energy expenditure. The American journal of physiology 261 (6 Pt 1):E789-794

    CAS  PubMed  Google Scholar 

  • Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, Kawai Y, Tsujisaki M (2009) High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58 (7):1526–1531. doi:10.2337/db09-0530

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Schoeller DA (1999) Recent advances from application of doubly labeled water to measurement of human energy expenditure. The Journal of nutrition 129 (10):1765–1768

    CAS  PubMed  Google Scholar 

  • Schulz LO, Schoeller DA (1994) A compilation of total daily energy expenditures and body weights in healthy adults. The American journal of clinical nutrition 60 (5):676–681

    CAS  PubMed  Google Scholar 

  • Shekelle PG, Hardy ML, Morton SC, Maglione M, Mojica WA, Suttorp MJ, Rhodes SL, Jungvig L, Gagne J (2003) Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis. Jama 289 (12):1537–1545. doi:10.1001/jama.289.12.1537

    CAS  PubMed  Google Scholar 

  • Sims EA, Danforth E, Jr., Horton ES, Bray GA, Glennon JA, Salans LB (1973) Endocrine and metabolic effects of experimental obesity in man. Recent progress in hormone research 29:457–496

    CAS  PubMed  Google Scholar 

  • Smith SR, de Jonge L, Zachwieja JJ, Roy H, Nguyen T, Rood JC, Windhauser MM, Bray GA (2000) Fat and carbohydrate balances during adaptation to a high-fat. The American journal of clinical nutrition 71 (2):450–457

    CAS  PubMed  Google Scholar 

  • Speakman JR (1998) The history and theory of the doubly labeled water technique. The American journal of clinical nutrition 68 (4):932S-938S

    CAS  PubMed  Google Scholar 

  • Spiller RC (1994) Intestinal absorptive function. Gut 35 (1 Suppl):S5-9

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Spraul M, Ravussin E, Fontvieille AM, Rising R, Larson DE, Anderson EA (1993) Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain. The Journal of clinical investigation 92 (4):1730–1735. doi:10.1172/JCI116760

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, Gortmaker SL (2011) The global obesity pandemic: shaped by global drivers and local environments. Lancet 378 (9793):804–814. doi:10.1016/S0140-6736(11)60813-1

    Google Scholar 

  • Tataranni PA, Larson DE, Snitker S, Ravussin E (1995) Thermic effect of food in humans: methods and results from use of a respiratory chamber. The American journal of clinical nutrition 61 (5):1013–1019

    CAS  PubMed  Google Scholar 

  • Tataranni PA, Young JB, Bogardus C, Ravussin E (1997) A low sympathoadrenal activity is associated with body weight gain and development of central adiposity in Pima Indian men. Obesity research 5 (4):341–347

    Article  CAS  PubMed  Google Scholar 

  • van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJ (2009) Cold-activated brown adipose tissue in healthy men. The New England journal of medicine 360 (15):1500–1508. doi:10.1056/NEJMoa0808718

    Article  PubMed  Google Scholar 

  • van Ooijen AM, van Marken Lichtenbelt WD, van Steenhoven AA, Westerterp KR (2005) Cold-induced heat production preceding shivering. The British journal of nutrition 93 (3):387–391

    Article  PubMed  Google Scholar 

  • Villablanca PA, Alegria JR, Mookadam F, Holmes DR, Jr., Wright RS, Levine JA (2015) Nonexercise activity thermogenesis in obesity management. Mayo Clinic proceedings 90 (4):509–519. doi:10.1016/j.mayocp.2015.02.001

    Article  PubMed  Google Scholar 

  • Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerback S, Nuutila P (2009) Functional brown adipose tissue in healthy adults. The New England journal of medicine 360 (15):1518–1525. doi:10.1056/NEJMoa0808949

    Article  CAS  PubMed  Google Scholar 

  • Vybiral S, Lesna I, Jansky L, Zeman V (2000) Thermoregulation in winter swimmers and physiological significance of human catecholamine thermogenesis. Experimental physiology 85 (3):321–326

    Article  CAS  PubMed  Google Scholar 

  • Westerterp KR, Speakman JR (2008) Physical activity energy expenditure has not declined since the 1980s and matches energy expenditures of wild mammals. International journal of obesity 32 (8):1256–1263. doi:10.1038/ijo.2008.74

    Article  CAS  PubMed  Google Scholar 

  • Weststrate JA (1993) Resting metabolic rate and diet-induced thermogenesis: a methodological reappraisal. The American journal of clinical nutrition 58 (5):592–601

    CAS  PubMed  Google Scholar 

  • Weyer C, Pratley RE, Salbe AD, Bogardus C, Ravussin E, Tataranni PA (2000) Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight change. The Journal of clinical endocrinology and metabolism 85 (3):1087–1094. doi:10.1210/jcem.85.3.6447

    Article  CAS  PubMed  Google Scholar 

  • Weyer C, Tataranni PA, Snitker S, Danforth E, Jr., Ravussin E (1998) Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans. Diabetes 47 (10):1555–1561

    Article  CAS  PubMed  Google Scholar 

  • Wijers SL, Schrauwen P, Saris WH, van Marken Lichtenbelt WD (2008) Human skeletal muscle mitochondrial uncoupling is associated with cold induced adaptive thermogenesis. PloS one 3 (3):e1777. doi:10.1371/journal.pone.0001777

    Article  PubMed Central  PubMed  Google Scholar 

  • Zingaretti MC, Crosta F, Vitali A, Guerrieri M, Frontini A, Cannon B, Nedergaard J, Cinti S (2009) The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23 (9):3113–3120. doi:10.1096/fj.09-133546

    Article  CAS  Google Scholar 

  • Zurlo F, Ferraro RT, Fontvielle AM, Rising R, Bogardus C, Ravussin E (1992) Spontaneous physical activity and obesity: cross-sectional and longitudinal studies in Pima Indians. The American journal of physiology 263 (2 Pt 1):E296-300

    CAS  PubMed  Google Scholar 

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Acknowledgment

This work is supported by grant P01-DK-049210 from the National Institutes of Health, USA.

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Ahima, R.S. (2015). Principles of Energy Homeostasis. In: Ahima, R. (eds) Metabolic Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-319-12125-3_48-1

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  1. Latest

    Principles of Energy Homeostasis
    Published:
    15 September 2023

    DOI: https://doi.org/10.1007/978-3-319-12125-3_48-2

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    Principles of Energy Homeostasis
    Published:
    23 July 2015

    DOI: https://doi.org/10.1007/978-3-319-12125-3_48-1